HMG-CoA reductase / HMGCR antibody

Principal name

HMG-CoA reductase / HMGCR antibody

Alternative names for HMG-CoA reductase / HMGCR antibody

3-hydroxy-3-methylglutaryl-coenzyme A reductase

SwissProt ID

P00347 (Crigr), P04035 (Human), P20715 (Xenla), P51639 (Rat), Q01237 (Mouse)

Gene ID

3156 (HMGCR)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of HMG-CoA reductase / HMGCR antibody

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HMG-CoA reductase / HMGCR antibody

Immunohistochemistry (IHC) analysis of HMGCR polyclonal antibody in paraffin-embedded Mouse Liver Cancer tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

HMG-CoA reductase / HMGCR antibody

Predicted band size: 95 kDa . Positive control: Hepg2 and HeLa cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: Hepg2 cell lysate Lane2: HeLa cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HMG-CoA reductase / HMGCR antibody

HMG-CoA reductase / HMGCR Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

HMG-CoA reductase / HMGCR antibody

Immunohistochemistry-Paraffin: HMGCR Antibody [NBP1-91996] Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HMG-CoA reductase / HMGCR

HMG-CoA reductase / HMGCR Human
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HMGCR 293T Cell Transient Overexpression Lysate(Denatured)

HMGCR 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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