HMGA1 / HMGIY antibody

Principal name

HMGA1 / HMGIY antibody

Alternative names for HMGA1 / HMGIY antibody

High mobility group protein HMG-I/HMG-Y, High mobility group protein A1, High mobility group protein R, High mobility group AT-hook protein 1

SwissProt ID

P17095 (Mouse), P17096 (Human), Q6URC2 (Canfa), Q8K585 (Rat), Q9QXP3 (Crigr)

Gene ID

3159 (HMGA1), 111241 (Hmga1-rs1), 15361 (Hmga1), 117062

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Dros (Drosophila), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Ze (Zebrafish), L (Lizard), Bear, GP (Guinea Pig)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of HMGA1 / HMGIY antibody

HMGA1, an 11KDa basic, DNA-binding non-histone nuclear protein, is a key member of HMGA protein family. It consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. It also physically interacts with transcription factors such as AP-1, Sp-1 and CAAT/enhancer binding protein-beta to modulate their ability to activate gene expression. It functions as a direct transcriptional target of c-Jun and c-Myc and is maximally expressed during embryonic development. Pathological role of HMGA1 include integration of retroviruses into chromosomes and enhancing metastasis of tumor cells.

General readings

Chiappetta G, Botti G, Monaco M, Pasquinelli R, Pentimalli F, Di Bonito M, D'Aiuto G, Fedele M, Iuliano R, Palmieri EA, Pierantoni GM, Giancotti V, Fusco A.
HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression.
Clin Cancer Res. 2004 Nov 15;10(22):7637-44
15569996.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HMGA1 / HMGIY (9-21) antibody

  Goat Anti-HMGA1 (aa9-21) Antibody  
TA305717 (0.5ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY antibody

  Goat Anti-HMGA1 Antibody  
TA305780 (4ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY antibody

  Anti-HMGA1 Rabbit Polyclonal Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using HMGA1 Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY antibody

  Anti-HMGA1 Rabbit Polyclonal Antibody  
Gel: 12%SDS-PAGE, Lysate: 40 µg, Lane: HT-29 cell, Primary antibody: HMGA1 Antibody at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY (C-term) antibody

  Rabbit polyclonal HMGA1 Antibody (C-term)  
HMGA1 Antibody (C-term) (Cat. #TA325094) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HMGA1 antibody detected the HMGA1 protein (arrow). Rabbit Ig Purified Hu, Ms F, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY antibody

  Rabbit Polyclonal Anti-HMGA1 Antibody  
WB Suggested Anti-HMGA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HT1080 cell lysate. HMGA1 is strongly supported by BioGPS gene expression data to be expressed in Human HT1080 cells Rabbit IgG Purified Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY antibody

  Rabbit Polyclonal Anti-Hmga1 Antibody  
WB Suggested Anti-Hmga1 Antibody; Titration: 2 ug/ml; Positive Control: Rat Small Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HMGA1 / HMGIY (1-50) antibody

AP08444PU-N HMGA1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Placenta at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Amoeba, Bt, Can, Capsospora, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

HMGA1 / HMGIY (12-23) antibody

Human Placenta (formalin-fixed, paraffin-embedded) stained with HMGA1 antibody AP22498PU-N at 4 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

HMGA1 / HMGIY (9-21) antibody

IHC Image of AP23070PU-N
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

HMGA1 - human gene knockout kit via CRISPR

HMGA1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HMGA1 - human gene knockout kit via CRISPR

HMGA1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HMGA1 - human gene knockout kit via CRISPR

HMGA1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HMGA1 - human gene knockout kit via CRISPR

HMGA1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hmga1 - mouse gene knockout kit via CRISPR

Hmga1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hmga1 - mouse gene knockout kit via CRISPR

Hmga1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hmga1 - mouse gene knockout kit via CRISPR

Hmga1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hmga1 - mouse gene knockout kit via CRISPR

Hmga1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HMGA1 / HMGIY (transcript variant 2)

  Recombinant protein of human high mobility group AT-hook 1 (HMGA1), transcript variant 2  
HMGA1 / HMGIY Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

HMGA1 / HMGIY (transcript variant 1)

  Recombinant protein of human high mobility group AT-hook 1 (HMGA1), transcript variant 1  
HMGA1 / HMGIY Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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