HPV16 E7 protein antibody

Principal name

HPV16 E7 protein antibody

Alternative names for HPV16 E7 protein antibody

Human Papilloma Virus Early protein 7

SwissProt ID

P03129 (Hpv16)

Gene ID

1489079 (E7)

Available reactivities

Hu (Human), Vi (Virus), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Radioimmunoassay (R), Paraffin Sections (P), ELISA (capture) (E(capture))

Background of HPV16 E7 protein antibody

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb. This sequence is also present in SV40 and polyoma large T antigens. The high risk HPV E7 proteins (of, for example, types 16 and 18) have an approximately ten-fold higher affinity for pRb protein than the low risk HPV E7 proteins (of, for example, type 6). Association of the E7 protein with pRb promotes cell proliferation by the same mechanism as the E1A proteins of adenoviruses and SV40 large T antigen. Recent studies have shown that E7 promotes degradation of Rb family proteins rather than simply inhibiting their function by complex formation. The CR2 region also contains the casein kinase II phosphorylation site (residues 31 and 32). Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG2a 289-17013 Purified Hu C, E, F, IP, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

HPV16 E7 protein antibody

Western blot analysis using E7 mouse mAb against truncated GST-E7 recombinant protein (1). Mouse IgG1 3D6F1 Ascites WB
0.1 ml / €400.00
  Acris Antibodies GmbH

HPV16 E7 protein antibody

Immunohistochemical analysis of paraffin-embedded placenta tissues (left) and ovarian cancer (right) using HPV16 E7 antibody Cat.-No AM06592SU-N with DAB staining. Mouse IgG1 6F3 Ascites Hu E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG2a B716M Purified Hu E, E(capture), WB
1 mg / €470.00
  Acris Antibodies GmbH

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 B817M Purified Hu E, E(detection), WB
1 mg / €470.00
  Acris Antibodies GmbH

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 B616M Purified Hu E, E(detection), WB
1 mg / €470.00
  Acris Antibodies GmbH

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-E11 E, WB
0.2 mg / €470.00
  Abnova Taiwan Corp.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-F10 E, WB
0.2 mg / €470.00
  Abnova Taiwan Corp.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-332 E, WB
0.2 mg / €470.00
  Abnova Taiwan Corp.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-332 Purified E, E(detection), WB
1 mg / €370.00
  HyTest Ltd.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-E11 Purified E, E(detection), WB
1 mg / €370.00
  HyTest Ltd.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-F10 Purified E, E(detection), WB
1 mg / €370.00
  HyTest Ltd.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-E11 Purified Vi E, WB
0.2 mg / €290.00
  Novus Biologicals Inc.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-F10 Purified Vi E, WB
0.2 mg / €290.00
  Novus Biologicals Inc.

HPV16 E7 protein antibody

HPV16 E7 protein Mouse IgG1 716-332 Purified Vi E, WB
0.2 mg / €290.00
  Novus Biologicals Inc.

15 Item(s)

per page
  • LinkedIn