HSBP1 / HSF1BP antibody
Principal name
HSBP1 / HSF1BP antibody
Alternative names for HSBP1 / HSF1BP antibody
Heat shock factor-binding protein 1, NPC-A-13, Nasopharyngeal carcinoma-associated antigen 13
Ncbi ID
NP_001528.1, 9606, NP_001528, NM_001537, NP_077181.1, NM_024219, NM_173119
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB)
Background of HSBP1 / HSF1BP antibody
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
General readings
Tai,L.J., (2002) J. Biol. Chem. 277 (1), 735-745
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA339061 | HSBP1 / HSF1BP antibody |
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| Rabbit Polyclonal Anti-HSBP1 Antibody | |||||||
 |
Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
€325.00
|
|
| OriGene Technologies, Inc. | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN201399 | HSBP1 - human gene knockout kit via CRISPR |
||
 |
Human | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN307960 | Hsbp1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN307960BN | Hsbp1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN307960LP | Hsbp1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN307960RB | Hsbp1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP301399 | HSBP1 / HSF1BP |
||||
| Recombinant protein of human heat shock factor binding protein 1 (HSBP1) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
Regular Price: 20 µg / €680.00 Special Price: 20 µg / €398.00 |
|
| OriGene Technologies, Inc. | |||||
|
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| SA6022 | HSBP1 / HSF1BP |
||||
 |
Human | Purified | > 95 % by SDS-PAGE | E. coli |
0.1 mg /
€230.00
|
| Acris Antibodies GmbH | |||||
 +1 additional image |
|||||
| SA6022X | HSBP1 / HSF1BP |
||||
|
Human | Purified | > 95 % by SDS-PAGE | E. coli |
0.5 mg /
€540.00
|
| Acris Antibodies GmbH | |||||
| +1 additional image |
|||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY419869 | HSBP1 overexpression lysate |
|
|
0.1 mg /
€280.00
|
|
| OriGene Technologies, Inc. |
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC201399L2V | Lenti ORF particles, HSBP1 (mGFP-tagged) - Human heat shock factor binding protein 1 (HSBP1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€880.00
|
|
| OriGene Technologies, Inc. | ||
| RC201399L1V | Lenti ORF particles, HSBP1 (Myc-DDK tagged) - Human heat shock factor binding protein 1 (HSBP1) , 200 uL, >10^7 TU/mL |
|
|
200 µl /
€780.00
|
|
| OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR200108L2V | Lenti ORF particles, Hsbp1 (GFP-tagged) - Mouse heat shock factor binding protein 1 (Hsbp1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€880.00
|
|
| OriGene Technologies, Inc. | ||
| MR200108L1V | Lenti ORF particles, Hsbp1 (Myc-DDK-tagged) - Mouse heat shock factor binding protein 1 (Hsbp1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€780.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR211803L2V | Lenti ORF particles, Hsbp1 (GFP-tagged ORF) - Rat heat shock factor binding protein 1 (Hsbp1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€880.00
|
|
| OriGene Technologies, Inc. | ||
| RR211803L1V | Lenti ORF particles, Hsbp1 (Myc-DDK-tagged ORF) - Rat heat shock factor binding protein 1 (Hsbp1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€780.00
|
|
| OriGene Technologies, Inc. | ||
