HSBP1 / HSF1BP antibody

Principal name

HSBP1 / HSF1BP antibody

Alternative names for HSBP1 / HSF1BP antibody

Heat shock factor-binding protein 1, NPC-A-13, Nasopharyngeal carcinoma-associated antigen 13

SwissProt ID

O75506 (Human), Q3ZC22 (Bovin), Q8K3X8 (Rat), Q9CQZ1 (Mouse)

Gene ID

3281 (HSBP1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of HSBP1 / HSF1BP antibody

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

General readings

Tai,L.J., (2002) J. Biol. Chem. 277 (1), 735-745

11 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HSBP1 / HSF1BP antibody

WB Suggested Anti-HSBP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

HSBP1 / HSF1BP antibody

HSBP1 / HSF1BP Mouse IgG2a 2C3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HSBP1 / HSF1BP antibody

Human Brain; WB Suggested Anti-HSBP1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human brain; HSBP1 antibody - N-terminal region (ARP35643_P050) in Human Brain cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

HSBP1 / HSF1BP antibody

Immunohistochemistry-Paraffin: HSBP1 Antibody [NBP1-86373] Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity with a granular pattern in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HSBP1 / HSF1BP

HSBP1 / HSF1BP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

HSBP1 / HSF1BP

HS6ST1 monoclonal antibody (M05A), clone 1H4. Western Blot analysis of HS6ST1 expression in IMR-32(Cat # L008V1 ). Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

HSBP1 / HSF1BP

HS6ST1 monoclonal antibody (M05A), clone 1H4. Western Blot analysis of HS6ST1 expression in IMR-32(Cat # L008V1 ). Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

HSBP1 / HSF1BP

HSBP1 / HSF1BP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

HSBP1 / HSF1BP

HSBP1 / HSF1BP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

HSBP1 / HSF1BP

SDS-Page: HSBP1 Protein [NBC1-18355] - HSBP1, 8.5kDa (76aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
0.1 mg / €310.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

HSBP1 overexpression lysate

HSBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

11 Item(s)

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