HSD17B10 / ERAB antibody

Principal name

HSD17B10 / ERAB antibody

Alternative names for HSD17B10 / ERAB antibody

HADH2, MRPP2, SCHAD, XH98G2, 17-beta-HSD10, Mitochondrial Marker, 17-beta-hydroxysteroid dehydrogenase 10, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, 3-hydroxyacyl-CoA dehydrogenase type-2, 3-hydroxyacyl-CoA dehydrogenase type II, Type II HADH, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, Mitochondrial ribonuclease P protein 2, Short-chain type dehydrogenase/reductase XH98G2

SwissProt ID

O02691 (Bovin), O08756 (Mouse), O18404 (Drome), O70351 (Rat), Q99714 (Human)

Gene ID

3028 (HSD17B10)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Mky (Monkey), Xen (Xenopus), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of HSD17B10 / ERAB antibody

ERAB is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. It has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD, a disorder characterized by neurological abnormalities, including psychomotor retardation and loss of mental and motor skills).
Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Abundant in human liver, kidney and gonads, but it is present in only negligible amounts in skeletal muscle. At the sub-cellular level, in normal tissues, this protein is located in mithocondria. It is over-expressed in Neurons of patients with Alzheimer's disease.

General readings

He XY, Schulz H, Yang SY. A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimers disease. J Biol Chem. 1998 Apr 24;273(17):10741-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HSD17B10 / ERAB antibody

  anti-HSD17B10 mouse monoclonal antibody, clone OTI10B4 (formerly 10B4)  
Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-HSD17B10mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500686, Dilution 1:50) Mouse IgG1 OTI10B4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HSD17B10 / ERAB antibody

  HSD17B10 mouse monoclonal antibody, clone OTI11A2 (formerly 11A2)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-HSD17B10 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500724) Mouse IgG2b OTI11A2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HSD17B10 / ERAB antibody

  anti-HSD17B10 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-HSD17B10 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500813, Dilution 1:50) Mouse IgG2a OTI5E2 Purified Hu, Mky F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

HSD17B10 / ERAB antibody

  Goat Polyclonal Antibody against HADH2  
TA302984 staining (0.3µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Mky, Ms, Rt, Xen, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit anti-HADH2 polyclonal antibody  
Western blot analysis of Jurkat cells (Lane 1: 50ug lysate), EC9706 cells (Lane 2: 57ug lysate) and SGC cells (Lane 3: 50ug lysate) with anti-HADH2 antibody diluated at 1:1000. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit polyclonal anti-ABAD/HADH2 antibody  
Western blot analysis of ABAD/HADH2 using Jurkat cell lysate (Lane 1& 2). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit polyclonal anti-ERAB/HCD2 antibody  
Western blot analysis of ERAB/HCD2 using rat kidney tissue lysate (Lane 1), mouse 3T3 cell lysate (Lane 2) and Jurkat cell lysate (Lane 3 & 4). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit polyclonal ERAB antibody  
Western blot analysis of extracts from LOVO cells, using ERAB antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit anti-HSD17B10 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using HSD17B10 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit Polyclonal Anti-ERAB Antibody  
Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ERAB Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Mouse Monoclonal anti-ERAB Antibody  
Mitochondrial localization of ERAB in human neuroblastoma cells SK-N-SH visualized with MAb 5F3 and laser-scanning confocal microscope. A. MAb to mitochondria visualized with Cy-5-conjugated secondary antibodies. B. MAb 5F3 to ERAB-FITC-conjugated. C. Merged image. Mouse 5F3 Purified Hu P
200 µl / €479.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  Rabbit Polyclonal anti-ERAB Antibody  
HSD17B10 / ERAB Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSD17B10 / ERAB antibody

  anti-HSD17B10 mouse monoclonal antibody, clone OTI3B5 (formerly 3B5)  
Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-HSD17B10 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500687, Dilution 1:50) Mouse IgG1 OTI3B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HSD17B10 / ERAB (C-term) antibody

Immunohistochemistry on Formalin-fixed and paraffin-embedded human prostate tissue. (Top)Coloration with the Anti-ABAD antibody at a 1:20 concentration. (Bottom)Antibody adsorbed to the antigen (peptide), negative control.Disappearance of cytoplasmic staining indicating the antibody is specific. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HSD17B10 / ERAB antibody

Immunohistochemistry analyzes of HADH2 antibody (AP20285PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HSD17B10 / ERAB antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ERAB Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

HSD17B10 / ERAB antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ERAB Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

HSD17B10 - human gene knockout kit via CRISPR

HSD17B10 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HSD17B10 - human gene knockout kit via CRISPR

HSD17B10 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD17B10 - human gene knockout kit via CRISPR

HSD17B10 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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