HSP90AB1 / HSP90 beta antibody

Principal name

HSP90AB1 / HSP90 beta antibody

Alternative names for HSP90AB1 / HSP90 beta antibody

HSP90B, HSPC2, HSPCB, Heat shock protein HSP 90-beta, Heat shock 84 kDa, HSP84

SwissProt ID

O57521, P08238 (Human), P11499 (Mouse), P30947 (Rabit), P34058 (Rat), Q04619 (Chick), Q76LV1 (Bovin), Q9GKX8 (Horse)

Gene ID

3326 (HSP90AB1), 30573 (hsp90ab1)

Available reactivities

Bac (Bacteria), Bov (Bovine), Can (Canine), Chk (Chicken), Fi (Fish), GP (Guinea Pig), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Salmonid, African clawed frog, Carp, Hst (Hamster), Frog, Av (Birds), Ze (Zebrafish), Xen (Xenopus), Bacillus sp., Prim (Primate)

Available hosts

Mouse, Rabbit, Rat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of HSP90AB1 / HSP90 beta antibody

HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms α and β, which share 85% sequence amino acid homology. The two isoforms of Hsp90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90α exists predominantly as a homodimer while HSP90β exists mainly as a monomer.(2) From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. (3-6) Furthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90-regulated proteins that have been discovered to date are involved in cell signaling (7-8). The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5 When bound to ATP, Hsp90 interacts with cochaperones Cdc37, p23, and an assortment of immunophilinlike proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation.
In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function (9).

General readings

General / background references:Feng H et al. Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells. Blood 100:4108-15 (2002). PubMed PMID: 12393401
Gebhard B et al. MHC-class-I expression in human breast cancer correlates with nuclear localization of the 90 kDa heat-shock-protein. Anticancer Res 19:5293-7 (1999). PubMed PMID: 10697551
Imamura T et al. Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. J Biol Chem 273:11183-8 (1998). PubMed PMID: 9556607
Smith DF et al. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol Cell Biol 13:869-76 (1993). PubMed PMID: 8423808
Redmond T et al. Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells. Eur J Cell Biol 50:66-75 (1989). PubMed PMID: 2693091
Riehl RM et al. Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species. Biochemistry 24:6586-91 (1985). PubMed PMID: 4084541

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Heat Shock Protein 90 (HSP90) alpha/beta antibody

Western blot analysis of Hsp90 -lane1-hsp90alpha-lane2-hsp90beta- showing Hsp90 specificity. Rabbit Serum Hu, Ms, Rt C, E, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat Shock Protein 90 (HSP90) alpha/beta antibody

Western blot analysis of Hsp90 -lane1-hsp90alpha-lane2-hsp90beta- showing Hsp90 specificity. Rabbit Serum Hu, Ms, Rt C, E, IP, P, WB
25 µl / €200.00
  Acris Antibodies GmbH

Heat Shock Protein 90 / HSP90 (250-325) antibody

IHC Image for AP22893PU-N
Small intestine, myenteric plexus, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Can, Hu, Ms, Rb, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

IHC staining of inflammatory cells and epithelia mucosa in mouse colon tissues. Mouse IgG2b AC-16 Purified Achyla, Bacillus sp., Chk, Hu, Ms, Rb, Rt, Sf9 cell line, Wheat Germ WB
50 µg / €325.00
  OriGene Technologies, Inc.

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Western blot analysis of Hsp90Total in rat tissues, using a 1:1000 dilution of the antibody Mouse IgG1 4F3.E8 Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

IHC staining of inflammatory cells and epithelia mucosa in mouse colon tissues. Mouse IgG2b AC-16 Purified Achyla, Bacillus sp., Chk, Hu, Ms, Rb, Rt, Sf9 cell line, Wheat Germ C, WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Western blot analysis of Hsp90Total in rat tissues, using a 1:1000 dilution of the antibody Mouse IgG1 4F3.E8 Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, WB
50 µg / €230.00
  Acris Antibodies GmbH

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Western blot analysis of Hsp90 with Heat Shocked Human HeLa cell lysate using this HSP90 antibody. Mouse IgG1 S88 Aff - Purified Bov, GP, Hst, Hu, Mky, Ms, Rb, Rt C, ICC/IF, IP, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

Heat Shock Protein 90 / HSP90 antibody

Heat Shock Protein 90 / HSP90 Mouse IgG2b SJ-90 Purified Chk, Frog, Hu, Ms, Rb, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Heat Shock Protein 90 / HSP90 Mouse IgG2b SJ-90 Chk, Frog, Hu, Ms, Rb, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Heat Shock Protein 90 / HSP90 Mouse IgG2b AC-16 Av, Chk, Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Heat Shock Protein 90 / HSP90 Rabbit Serum Hu, Salmonid WB
0.1 ml / €380.00
  AgriSera AB

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Heat Shock Protein 90 / HSP90 Mouse IgG1 AC88 Purified Bac, Bov, Can, Chk, Fi, GP, Hu, Mky, Ms, Por, Rb, Rt, Sh P, WB
0.1 mg / €380.00
  Novus Biologicals Inc.

Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

Western Blot: Hsp 90 Antibody (S88) [NB120-1429] - Western blot analysis of  Hsp90 with heat shocked  human HeLa cell lysate. Mouse IgG1 S88 Serum Bov, Hu, Mky, Ms, Rb, Rt ICC/IF, IP, P, WB
50 µg / €360.00
  Novus Biologicals Inc.

HSP90AB1 / HSP90 beta antibody

Western blot analysis of extracts from Hela cells treated with TNF-a (20ng/ml, 30min), using HSP90B (Ab-254) antibody (#TA312344, Line 1 and 2).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSP90AB1 / HSP90 beta antibody

Western blot analysis of extracts of variouscell lines, using HSP90AB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSP90AB1 / HSP90 beta antibody

Immunohistochemical analysis of paraffin-embedded kidney cancer tissues (left) and brain tissues (right) using HSP90AB1 mouse mAb with DAB staining. Mouse IgG1 5G4 Ascites Hu, Mky, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

HSP90AB1 / HSP90 beta antibody

Western blot analysis of Hsp90 using cell lysates from 12 human cancer cell lines at a 1:1000 dilution of TA309390. Mouse IgG2a H90-10 Purified Can, Chk, Hu, Rb, Rt C, E, ICC/IF, IP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

HSP90AB1 / HSP90 beta antibody

Western blot analysis of Hsp90Beta in a cell line mix, using a 1:2000 dilution of TA309400. Rabbit IgG Serum Hu, Ms, Rt C, E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSP90AB1 / HSP90 beta antibody

Western blot analysis of Hsp90beta in cell lysates from 12 human cancer cell lines at a 1:1000 dilution of TA309403. Mouse IgM Hyb-K3701 Purified Hu C, E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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