HSPB2 antibody

Principal name

HSPB2 antibody

Alternative names for HSPB2 antibody

Heat shock protein beta-2, DMPK-binding protein, MKBP

SwissProt ID

O35878 (Rat), Q16082 (Human), Q99PR8 (Mouse)

Gene ID

3316 (HSPB2), 69253 (Hspb2), 161476

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of HSPB2 antibody

HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS . MKBP is known to associate specifically with myotonic dystrophy protein kise (DMPK) in skeletal muscle. MKBP enhances the kise activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique ture compared to other sHSps, in that the expression of MKBP is not induced by heat shock . In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction . During stress, these complexes dissolve and MKBPs localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic . HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis .

General readings

Suzuki A., et al. (1998) J. Cell Biol. 140:1113-1124Iwaki A., et al. (1997) Genomics. 45:386-394

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HSPB2 antibody

  Rabbit polyclonal anti-HSPB2 antibody  
Western blot analysis of extracts from HepG2 cells and HeLa cells, using HSPB2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSPB2 antibody

  Anti-HSPB2 Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human lung cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using HSPB2 antibody at dilution 1/5, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HSPB2 antibody

  Rabbit polyclonal HSPB2 (MKBP) Antibody  
Western blot analysis of MKBP in a rat tissue mix using a 1:1000 dilution of the antibody Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HSPB2 antibody

  Rabbit Polyclonal Anti-HSPB2 Antibody  
WB Suggested Anti-HSPB2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: ACHN cell lysate.HSPB2 is supported by BioGPS gene expression data to be expressed in ACHN Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HSPB2 antibody

Immunofluorescence analysis of A549 cells, using HSPB2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

HSPB2 antibody

Immunofluorescence analysis of A549 cells, using HSPB2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

HSPB2 - human gene knockout kit via CRISPR

HSPB2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HSPB2 - human gene knockout kit via CRISPR

HSPB2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSPB2 - human gene knockout kit via CRISPR

HSPB2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSPB2 - human gene knockout kit via CRISPR

HSPB2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hspb2 - mouse gene knockout kit via CRISPR

Hspb2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hspb2 - mouse gene knockout kit via CRISPR

Hspb2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hspb2 - mouse gene knockout kit via CRISPR

Hspb2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hspb2 - mouse gene knockout kit via CRISPR

Hspb2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HSPB2

  Recombinant protein of human heat shock 27kDa protein 2 (HSPB2)  
HSPB2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

HSPB2 (1-182, His-tag)

HSPB2 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

HSPB2 (1-182, His-tag)

HSPB2 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HSPB2 (mGFP-tagged) - Human heat shock 27kDa protein 2 (HSPB2), 200 uL, >10^7 TU/mL

Lenti ORF particles, HSPB2 (mGFP-tagged) - Human heat shock 27kDa protein 2 (HSPB2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, HSPB2 (Myc-DDK tagged) - Human heat shock 27kDa protein 2 (HSPB2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, HSPB2 (Myc-DDK tagged) - Human heat shock 27kDa protein 2 (HSPB2) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hspb2 (GFP-tagged) - Mouse heat shock protein 2 (Hspb2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Hspb2 (GFP-tagged) - Mouse heat shock protein 2 (Hspb2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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