HTRA2 / PRSS25 antibody

Principal name

HTRA2 / PRSS25 antibody

Alternative names for HTRA2 / PRSS25 antibody

OMI, Serine protease 25, mitochondrial Serine protease HTRA2, High temperature requirement protein A2, Omi stress-regulated endoprotease, Serine proteinase OMI

SwissProt ID

A0JNK3 (Bovin), O43464 (Human), Q9JIY5 (Mouse)

Gene ID

27429 (HTRA2), 64704 (Htra2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP)

Background of HTRA2 / PRSS25 antibody

Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication (1). Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases (reviewed in 2). The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs (reviewed in 3). Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs (4). Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis (5).

General readings

Savopoulos JW., et al., (2000) Protein Expr. Purif. 19, 227-34.
Gray CW, et al., (2000) Eur. J. Biochem. 267, 5699-710.
Martins LM, et al., (2002) J. Biol. Chem. 277, 439-44.
Van Loo G, et al., (2002) Cell Death Differ. 9, 20-60.
Seong YM, et al., (2004) Protein Expr. Purif. 33, 200-8.

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CRISPR

Catalog No. Species Donor Vector  

Htra2 - mouse gene knockout kit via CRISPR

Htra2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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