Human IgE antibody

Principal name

Human IgE antibody

Alternative names for Human IgE antibody

Immunoglobulin E human

Available reactivities

Hu (Human), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Dot blot (Dot), Immunoprecipitation (IP), Immunodiffusion (ID), Functional assay (FN)

Background of Human IgE antibody

IgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150 ng/ml, compared to 10 mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity.
There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans.
IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.

General readings

Franklin E.C.: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95.
Fuller JM, Keyser J.W.: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71.
Balogh Z, Meretey K, Falus A, Bozsoky S.: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34.
Brinkmann V, Heusser CH.: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32.
Gould HJ, Beavil RL, Vercelli D.: IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation. Br Med Bull. 2000;56(4):908-24.

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Secondary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Human IgE

Human IgE Goat IgG HRP Hu, Mky E
1 mg / €350.00
  Acris Antibodies GmbH

Human IgE

Fig. 1. Flow Cytometry analysis of basophil activation upon stimulation of normal (heparin-treated) whole blood with combination of IL-3 and Goat anti-IgE polyclonal antibody.
Combination of anti-human IgE (BE5) FITC and anti-human CD63 (MEM-259) PE-Dyomics 647 was used (analysis in basophil window). 
Fig. 1A - staining of non-stimulated (control) sample
Fig. 1B - staining of IgE stimulated sample Mouse IgG1 BE5 FITC Hu F
0.1 mg / €230.00
  Acris Antibodies GmbH

Human IgE

Figure 2: staining of IgE stimulated sample Mouse IgG1 BE5 Purified Hu E, F
0.1 mg / €180.00
  Acris Antibodies GmbH

Human IgE

Fig. 1. Flow Cytometry analysis of basophil activation upon stimulation of normal (heparin-treated) whole blood with combination of IL-3 and Goat anti-IgE polyclonal antibody.
Combination of anti-human IgE (BE5) FITC and anti-human CD63 (MEM-259) PE-Dyomics 647 was used (analysis in basophil window). 
Fig. 1A - staining of non-stimulated (control) sample
Fig. 1B - staining of IgE stimulated sample Mouse IgG1 BE5 PE Hu F
0.1 mg / €270.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 090-11368 Purified Hu E, E(detection)
1 mg / €300.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 090-11348 Purified Hu E, E(detection)
1 mg / €300.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 090-18132 Purified Hu E, E(capture)
1 mg / €300.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG2b ME.114 Purified Hu E
1 mg / €390.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 1A2 HRP Hu E
0.5 mg / €1,290.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 1A2 Aff - Purified Hu E, WB
1 mg / €910.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 1A2 Aff - Purified Hu E, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 1A2 Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 4H10 FITC Hu F
0.1 mg / €230.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG1 4H10 Purified Hu E, F
0.1 mg / €180.00
  Acris Antibodies GmbH

Human IgE

Human IgE Mouse IgG2a E454 (5D5) Purified Hu E
1 mg / €500.00
  Acris Antibodies GmbH

Human IgE (Epsilon chain specific)

Human IgE Mouse IgM HP6061 Purified Hu E, E(capture)
0.5 mg / €230.00
  Acris Antibodies GmbH

Human IgE (Epsilon chain specific)

Human IgE Mouse IgG2a HP6029 AP Hu E
1 ml / €320.00
  Acris Antibodies GmbH

Human IgE (Epsilon chain specific)

Human IgE Mouse IgG2a HP6029 Biotin Hu E
0.5 mg / €320.00
  Acris Antibodies GmbH

Human IgE (Epsilon chain specific)

Human IgE Mouse IgG2a HP6029 HRP Hu E
1 ml / €300.00
  Acris Antibodies GmbH

Human IgE (Epsilon chain specific)

Human IgE Mouse IgG2a HP6029 Purified Hu C, Dot, E, ICC/IF, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

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