Human IgM antibody

Principal name

Human IgM antibody

Alternative names for Human IgM antibody

Human Immunoglobulin M

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit, Goat, Donkey, Rat, Sheep

Available applications

Frozen Sections (C), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Agglutination (AGG), Immunoprecipitation (IP), Immunodiffusion (ID), Dot blot (Dot), Functional assay (FN), Lateral Flow (LF), Radioimmunoassay (R)

Background of Human IgM antibody

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.

General readings

Franklin E.C.: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95.
Fuller JM, Keyser J.W.: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71.
Balogh Z, Meretey K, Falus A, Bozsoky S.: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34.
Brinkmann V, Heusser CH.: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32.

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Secondary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Human IgM (Fc-region)

Surface staining of Human peripheral blood cells with anti-Human IgM Antibody (CH2) APC conjuagetd Cat.-No SM3063APC. Cells in the lymphocyte gate were used for analysis. Mouse IgG1 CH2 APC Hu F
0.1 mg / €270.00
  Acris Antibodies GmbH

Human IgM (Fc-region)

Surface staining of human peripheral blood cells with anti-human IgM (CH2) PE. Mouse IgG1 CH2 FITC Hu F
0.1 mg / €230.00
  Acris Antibodies GmbH

Human IgM (Fc specific)

Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC.
Cells in the lymphocyte gate were used for analysis. Mouse IgG1 CH2 HRP Hu WB
0.1 mg / €270.00
  Acris Antibodies GmbH

Human IgM (Fc-region)

Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC. Cells in the lymphocyte gate were used for analysis. Mouse IgG1 CH2 Purified Hu E, F, ICC/IF, WB
0.1 mg / €180.00
  Acris Antibodies GmbH

Human IgM (Fc specific)

Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC.
Cells in the lymphocyte gate were used for analysis. Mouse IgG1 CH2 PE Hu F
0.1 mg / €270.00
  Acris Antibodies GmbH

Human IgM

Human IgM Mouse IgG1 3H10G5F2 Purified Hu E
0.1 ml / €270.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 APC Hu ICC/IF
0.1 mg / €360.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 AP Hu E
1 ml / €310.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 Biotin Hu E, ICC/IF
0.5 mg / €270.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 FITC Hu ICC/IF
0.5 mg / €300.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 HRP Hu E
1 ml / €300.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 Purified Hu C, Dot, E, ICC/IF, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG1 SA-DA4 PE Hu ICC/IF
0.1 mg / €290.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB APC Hu F
0.1 mg / €360.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB AP Hu E
1 ml / €310.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB Biotin Hu E, ICC/IF
0.5 mg / €270.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB FITC Hu ICC/IF
0.5 mg / €300.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB HRP Hu E
1 ml / €300.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB Low Endotoxin Hu C, Dot, E, ICC/IF, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

Human IgM (Mu chain specific)

Human IgM Mouse IgG3 UHB Purified Hu C, Dot, E, ICC/IF, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

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