Humanin antibody

Principal name

Humanin antibody

Alternative names for Humanin antibody

HN

SwissProt ID

Q8IVG9 (Human)

Ncbi ID

9606

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Humanin antibody

Humanin is a novel 24 A.A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Humanin antibody

  Rabbit Polyclonal Humanin Antibody  
Western Blot: Humanin Antibody [TA336626] - Western blot performed from 100ng of synthetic Humanin peptide and from 50 ug of total lysates of 293 T cells transfected with plasmids encoding GFPc1 or GFP-Humanin Conditions for the Western Blot: Lysis buffer Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Humanin antibody

Humanin Rabbit Aff - Purified Hu WB
0.1 ml / €330.00
  Neuromics Antibodies

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