HVCN1 / VSOP antibody

Principal name

HVCN1 / VSOP antibody

Alternative names for HVCN1 / VSOP antibody

HV1, Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, Voltage sensor domain-only protein

SwissProt ID

Q3U2S8 (Mouse), Q5M7E9 (Xenla), Q96D96 (Human)

Gene ID

84329 (HVCN1), 74096 (Hvcn1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of HVCN1 / VSOP antibody

Currents measured from voltage-gated proton channels were detected long before the channel (HVCN1, also known as Hv1 and VSOP) was cloned. HVCN1 has four membrane spanning domains and intracellular N- and C-termini. Interesting aspects of HVCN1 is that unlike its voltage-gated ion channel counterparts, it has no pore domain. Also, functiol HVCN1 channels are formed by dimers where each monomer has its own conducting pore, each with its own voltage sensor (voltage sensing occurs similarly to other voltage-gated ion channels). The fundamental role of HVCN1 is to pump out protons, thereby increasing the intracellular pH. The channel is exclusively selective for H+ and opens upon membrane depolarization, although its open state hugely depends on the pH on both sides of the membrane. Its role is best described in leukocytes where phosphorylation via PKC on a Thr residue potentiates the activity of the channel and increases its open state, thereby increasing the H+ current across the membrane, in this manner mediating optimal DPH-oxidase (whose optimal activity is at pH 7.5) required for the production of reactive oxygen species (ROS) necessary for phagocytosis to occur. Apart from leukocytes, HVCN1 is also expressed in basophils where its activation mediates histamine release. In B cells, it maintains optimal sigling, such that ROS production is maintained high. HVCN1 was found to regulate human spermatozoa activation. Filly, in the airway mucosa, where it regulates pH, channel gating there, is mostly mediated by differences in pH across the membrane as opposed to the membrane potential.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HVCN1 / VSOP antibody

Western blot analysis of HVCN1 in human spleen tissue lysate with HVCN1 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HVCN1 / VSOP antibody

Western blot analysis of mouse WEHI B-cell lymphoma (lanes 1 and 4), human HL-60 promyelocytic leukemia (lanes 2 and 5) and human THP-1 acute monocytic leukemia (lanes 3 and 6) cell lysates: 1-3. Anti-HVCN1 antibody, (1:200). 4-6. Anti-HVCN1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

HVCN1 / VSOP (C-term) antibody

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

HVCN1 / VSOP antibody

Immunohistochemical of paraffin-embedded tonsil sections stained with HVCN1 Antivody Cat.-No AP55392SU-N Rabbit Serum Hu C, E, ICC/IF, P, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

HVCN1 / VSOP antibody

HVCN1 / VSOP Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

HVCN1 / VSOP antibody

HVCN1 Antibody [NBP1-06585]-Immunohistochemistry of paraffin-embedded tonsil sections stained with anti-HVCN1 Rabbit Serum Hu, Ms E, P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

HVCN1 / VSOP antibody

HVCN1 / VSOP Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

HVCN1 / VSOP antibody

Immunohistochemistry-Paraffin: HVCN1 Antibody [NBP1-81643] Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells outside reaction centra. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HVCN1 / VSOP (transcript variant 2)

HVCN1 / VSOP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

HVCN1 overexpression lysate

HVCN1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

HVCN1 overexpression lysate

HVCN1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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