Hyaluronic acid synthase 1 / HAS1 antibody

Principal name

Hyaluronic acid synthase 1 / HAS1 antibody

Alternative names for Hyaluronic acid synthase 1 / HAS1 antibody

Hyaluronan synthase 1, Hyaluronate synthase 1, HAS

SwissProt ID

P13563 (Xenla), Q61647 (Mouse), Q92839 (Human)

Gene ID

3036 (HAS1)

Available reactivities

Vi (Virus), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of Hyaluronic acid synthase 1 / HAS1 antibody

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Hyaluronic acid synthase 1 / HAS1 antibody

Immunofluorescence analysis of U251 cells using HAS1 antibody Cat.-No AM06489SU-N (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 3E10 Ascites Hu E, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Hyaluronic acid synthase 1 / HAS1 antibody

Hyaluronic acid synthase 1 / HAS1 Rabbit Serum Vi WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Hyaluronic acid synthase 1 / HAS1 antibody

Immunofluorescence: Hyaluronan synthase 1 Antibody (3E10) [NBP1-51635] - Immunofluorescence analysis of U251 cells using HAS1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 3E10 Purified Hu E, ICC/IF, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

3 Item(s)

per page
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