Hyaluronic acid synthase 3 / HAS3 antibody

Principal name

Hyaluronic acid synthase 3 / HAS3 antibody

Alternative names for Hyaluronic acid synthase 3 / HAS3 antibody

Hyaluronan synthase 3, Hyaluronate synthase 3

SwissProt ID

O00219 (Human), O08650 (Mouse), O57425 (Chick), O57426 (Xenla)

Gene ID

3038 (HAS3), 3203038 (Q5WGN4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Eq (Equine), Xen (Xenopus), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)

Background of Hyaluronic acid synthase 3 / HAS3 antibody

HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGF Beta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1.

General readings

BMC Cancer. 2009 May 12;9:143.
BMC Cancer. 2010 Sep 27;10:512.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Hyaluronic acid synthase 3 / HAS3 antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer (Left) and  prostate (Right) tissues using HAS3 antibody Cat.-No AM06752PU-N with DAB staining. Mouse IgG1 3C9 Purified Hu E, F, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Hyaluronic acid synthase 3 / HAS3 antibody

WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hyaluronic acid synthase 3 / HAS3 antibody

WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hyaluronic acid synthase 3 / HAS3 antibody

Hyaluronic acid synthase 3 / HAS3 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Hyaluronic acid synthase 3 / HAS3 antibody

Human HeLa; WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Hela cell lysate; HAS3 antibody - N-terminal region (ARP46595_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Hyaluronic acid synthase 3 / HAS3 antibody

Transfected 293T; WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; HAS3 antibody - C-terminal region (ARP46596_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Hyaluronic acid synthase 3 / HAS3 antibody

Western Blot: HAS3 Antibody [NBP1-62551] - This Anti-HAS3 antibody was used in Western Blot of Hela tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Bov, Can, Chk, Eq, Hu, Ms, Por, Rb, Rt, Xen, Ze WB
50 µg / €440.00
  Novus Biologicals Inc.

Hyaluronic acid synthase 3 / HAS3 antibody

Immunohistochemistry-Paraffin: HAS3 Antibody [NBP1-86328] - Immunohistochemical staining of human kidney shows moderate membranous positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Hyaluronic acid synthase 3 / HAS3

Hyaluronic acid synthase 3 / HAS3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Hyaluronic acid synthase 3 / HAS3

Hyaluronic acid synthase 3 / HAS3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HAS3 293T Cell Transient Overexpression Lysate(Denatured)

HAS3 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HAS3 overexpression lysate

HAS3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

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