Hyaluronic acid synthase 3 / HAS3 antibody

Principal name

Hyaluronic acid synthase 3 / HAS3 antibody

Alternative names for Hyaluronic acid synthase 3 / HAS3 antibody

Hyaluronan synthase 3, Hyaluronate synthase 3

SwissProt ID

O00219 (Human), O08650 (Mouse), O57425 (Chick), O57426 (Xenla)

Gene ID

3038 (HAS3)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Hyaluronic acid synthase 3 / HAS3 antibody

HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGFβ downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1.

General readings

BMC Cancer. 2009 May 12;9:143.
BMC Cancer. 2010 Sep 27;10:512.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Hyaluronic acid synthase 3 / HAS3 antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer (Left) and  prostate (Right) tissues using HAS3 antibody Cat.-No AM06752PU-N with DAB staining. Mouse IgG1 3C9 Purified Hu E, F, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Hyaluronic acid synthase 3 / HAS3 antibody

  Rabbit Polyclonal Anti-HAS3 Antibody  
WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hyaluronic acid synthase 3 / HAS3 antibody

  Rabbit Polyclonal Anti-HAS3 Antibody  
WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hyaluronic acid synthase 3 / HAS3 antibody

WesternBlot (WB) analysis of HAS3 polyclonal antibody Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

HAS3 - human gene knockout kit via CRISPR

HAS3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HAS3 - human gene knockout kit via CRISPR

HAS3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HAS3 - human gene knockout kit via CRISPR

HAS3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HAS3 - human gene knockout kit via CRISPR

HAS3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

HAS3 overexpression lysate

HAS3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HAS3 (mGFP-tagged) - Human hyaluronan synthase 3 (HAS3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, HAS3 (mGFP-tagged) - Human hyaluronan synthase 3 (HAS3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, HAS3 (Myc-DDK tagged) - Human hyaluronan synthase 3 (HAS3), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, HAS3 (Myc-DDK tagged) - Human hyaluronan synthase 3 (HAS3), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

11 Item(s)

per page
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