IAP2 / BIRC2 antibody

Principal name

IAP2 / BIRC2 antibody

Alternative names for IAP2 / BIRC2 antibody

API1, MIHB, RNF48, Inhibitor of apoptosis protein 2, C-IAP1, cIAP1, IAP homolog B, HIAP2, HIAP-2, Baculoviral IAP repeat-containing protein 2, TNFR2-TRAF-signaling complex protein 2, RING finger protein 48

SwissProt ID

Q13490 (Human), Q62210 (Mouse)

Gene ID

329 (BIRC2), 330 (BIRC3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of IAP2 / BIRC2 antibody

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, (2,3). The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-alpha by its receptor (2,4). Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP (5). Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP (6).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IAP2 / BIRC2 antibody

Immunohistochemical staining of human adrenal gland shows strong nuclear and cytoplasmic positivity in cortical cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IAP2 / BIRC2 (361-372) antibody

Formalin-Fixed, Paraffin-Embedded Human Adrenal stained with IAP2 / BIRC2 antibody Cat.-No AP08427PU-N at 1/250 dilution after heat-induced antigen retrieval. Rabbit IgG Serum Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

IAP2 / BIRC2 (C-term) antibody

Western blot analysis of c-IAP in human lung lysate with c-IAP antibody at 1 (lane A), 2 (lane B), and 4 (lane C) ug/ml, respectively. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IAP2 / BIRC2 antibody

Predicted band size: 70 kDa . Positive control: Human fetal muscle tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IAP2 / BIRC2 antibody

Predicted band size: 70kDa. Positive control: SKOV3 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate:40 ug Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IAP2 / BIRC2 antibody

Western blot analysis of extracts of various cell lines, using BIRC2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

IAP2 / BIRC2 antibody

Western blot analysis of cIAP-1 in Jurkat cell lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €390.00
  Acris Antibodies GmbH

IAP2 / BIRC2 control peptide

IAP2 / BIRC2 Purified
50 µg / €190.00
  Acris Antibodies GmbH

IAP2 / BIRC2 antibody

Western blot analysis of cIAP-2 in Jurkat Cell Lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

IAP2 / BIRC2 antibody

Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IAP2 / BIRC2 Control Peptide

IAP2 / BIRC2
50 µg / €160.00
  Acris Antibodies GmbH

IAP2 / BIRC2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between BIRC2 and CASP9 HeLa cells were stained with anti-BIRC2 rabbit purified polyclonal 1:1200 and anti-CASP9 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

IAP2 / BIRC2 antibody

Immunohistochemical analysis of BIRC2 in formalin-fixed, paraffin-embedded human prostate. Using BIRC2 polyclonal antibody ( Cat # PAB0252 ) at 1 : 2000. A, normal prostate. B, prostate intraepithelial neoplasia ( PIN ) . PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased BIRC2 expression is PIN and in prostate cancer compared to normal prostate. Rabbit Hu, Ms, Rt C, IP, P, WB
50 µl / €400.00
  Abnova Taiwan Corp.

IAP2 / BIRC2 antibody

Western blot analysis of BIRC2 expression in mouse small intestine tissue lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

IAP2 / BIRC2 antibody

Western blot analysis of BIRC2 expression in Jurkat cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

IAP2 / BIRC2 antibody

Immunohistochemistry of BIRC2 in human lung with BIRC2 polyclonal antibody ( Cat # PAB12922 ) at 10 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

IAP2 / BIRC2 antibody

Western blot analysis of cIAP1 expression in HT29 (A); Jurkat (B); SP2/0 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

IAP2 / BIRC2 antibody

Western blot analysis of cIAP1 expression in HT29 (A); Jurkat (B); SP2/0 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

IAP2 / BIRC2 antibody

Western blot analysis of cIAP1 expression in HT29 (A); Jurkat (B); SP2/0 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

IAP2 / BIRC2 antibody

Western Blot: cIAP1 Antibody [29690002] - Samples:  Lane 1, Marker [kDa]: 250, 130, 95, 72, 55, 36, 28, 17, 11  Lane 2, RT-4  Lane 3, U-251MG sp Lane 4, Human Plasma  Lane 5, Liver  Lane 6, Tonsil, Target weight [kDa]:  70  Validation score:  2 Validation description: Supportive - Band of predicted size in kDa (+/-20%) with additional bands present. Rabbit Hu E, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

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