IAP3 / BIRC4 antibody

Principal name

IAP3 / BIRC4 antibody

Alternative names for IAP3 / BIRC4 antibody

HILP, API3, XIAP, Baculoviral IAP repeat-containing protein 4, E3 ubiquitin-protein ligase XIAP, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP

SwissProt ID

P98170 (Human), Q60989 (Mouse), Q9R0I6 (Rat)

Gene ID

331 (XIAP)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Rb (Rabbit), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of IAP3 / BIRC4 antibody

XIAP [human X-linked IAP, hILP (human IAP-like protein), MIHA, BIRC4) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-termil. The RING finger domain of several IAPs, including XIAP, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitition (Morizane et al, 2005). Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. XIAP is highly characterized with respect to its structure and biochemical mechanisms, and has received interest as a therapeutic target (reviewed in Schimmer, 2006). Since XIAP blocks a substantial portion of the apoptosis pathway and is associated with chemoresistance in cancer cells, inhibiting XIAP has been a focus for potential therapeutics. Approaches have included antisense oligonucleotides and small molecule inhibitors. Small molecules that that target the BIR2 and BIR3 domains of XIAP are considered particularly attractive. This is because the BIR domains inhibit caspase activity, and it is thought that removing the inhibition should increase the cell's ability to undergo apoptosis as well as decrease its potential for chemoresistance. Full-length human XIAP is a 497 amino acid protein and migrates at approx. 53 kDa on SDS-PAGE.

Items 1 to 20 of 43 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IAP3 / BIRC4 (C-term) antibody

Immunohistochemical staining of Human kidney tissue using AP30993PU-N XIAP antibody at 2 μg/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IAP3 / BIRC4 antibody

Western blot analysis of XIAP expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IAP3 / BIRC4 antibody

Western blot analysis of HeLa cell and C6 cell lysate using XIAP Antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IAP3 / BIRC4 antibody

Western Blot: XIAP Antibody [TA336331] - Analysis of recombinant full-length IAP proteins using polyclonal antibody to XIAP at 1:2000. The data shows that the antibody recognizes only XIAP and not the other IAP proteins. Rabbit Purified Hu, Ms, Rt C, IP, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

IAP3 / BIRC4 (352-449) antibody

IAP3 / BIRC4 Mouse IgG1 2F1 Azide Free Hu, Ms WB
0.1 mg / €360.00
  Acris Antibodies GmbH

IAP3 / BIRC4 control peptide

IAP3 / BIRC4 Purified
50 µg / €190.00
  Acris Antibodies GmbH

IAP3 / BIRC4 antibody

AP00062PU-N Western blot analysis of XIAP expression in Jurkat cell lysate. Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

IAP3 / BIRC4 antibody

Immunohistochemistry (IHC) analyzes of XIAP antibody (Cat.-No.: AP06595PU-N) in paraffin-embedded human skeletal muscle tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

IAP3 / BIRC4 antibody

Figure 2. Staining XIAP (BIRC4) in Liver by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IAP3 / BIRC4 (N-term) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with BIRC4 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IAP3 / BIRC4 (75-226) antibody

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Por, Rb, Rt ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

IAP3 / BIRC4 Control Peptide

IAP3 / BIRC4
50 µg / €160.00
  Acris Antibodies GmbH

IAP3 / BIRC4 pSer87 antibody

Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) antibody AP55908PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

IAP3 / BIRC4 pSer87 antibody

Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) antibody AP55908PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

IAP3 / BIRC4 antibody

BIRC4 MaxPab polyclonal antibody. Western Blot analysis of BIRC4 expression in human colon. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

IAP3 / BIRC4 antibody

BIRC4 MaxPab polyclonal antibody. Western Blot analysis of BIRC4 expression in human colon. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

IAP3 / BIRC4 antibody

IAP3 / BIRC4 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

IAP3 / BIRC4 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between XIAP and CASP9 HeLa cells were stained with anti-XIAP rabbit purified polyclonal 1:1200 and anti-CASP9 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

IAP3 / BIRC4 antibody

Detection limit for recombinant GST tagged BIRC4 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2B3 Purified Hu E, WB
50 µg / €370.00
  Abnova Taiwan Corp.

IAP3 / BIRC4 antibody

IAP3 / BIRC4 Mouse IgG2a 2B3 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Items 1 to 20 of 43 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn