IDO1 / INDO antibody

Principal name

IDO1 / INDO antibody

Alternative names for IDO1 / INDO antibody

IDO1, IDO, INDO, Indoleamine 2,3-dioxygenase 1, EC=1.13.11.52, Indoleamine 2,3-dioxygenase, IDO, Indoleamine-pyrrole 2,3-dioxygenase

SwissProt ID

P14902 (Human), P28776 (Mouse), Q9ERD9 (Rat)

Gene ID

3620 (IDO1), 15930 (Ido1), 11083 (DIDO1), 66029

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Sh (Sheep)

Available hosts

Sheep, Mouse, Rat, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of IDO1 / INDO antibody

The polyclonal antibody recognizes rat indoleamine 2,3-dioxygenase 1 (IDO1 or INDO). IDO1 is an intracellular heme-containing enzyme of 45 kD that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules, like tryptophan, serotonin and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia. By local depletion of tryptophan and increasing proapoptotic kynurenines, IDO1 greatly affects T-cell proliferation and survival, both in vitro and in vivo, and also affects B-cell and NK-cell function and survival. There is a central role for IDO1 expression in tolerance involving regulatory cells and DCs. IDO1 acts as an intermediate pathway in LPS-induced production of reactive oxygen species and NF-kappaB activation, two processes that lead to DC maturation. In addition to classic IDO (IDO1) indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein or proto-indoleamine 2,3 dioxygenase (IDO2, IDO-2, INDOL1 or proto-IDO) has been described.

General readings

Metz R., et al (2007). Nature Cancer Res. 67:7082-7087Yuasa H.J., et al (2007). J. Mol. Evol. 65:705-714

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-IDO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506367) Mouse IgG1 OTI2G4 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-IDO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506402) Mouse IgG1 OTI1A3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-IDO1 mouse monoclonal antibody. (UM500091; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB126 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-IDO1 mouse monoclonal antibody. (UM500091; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB126 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

IDO1 / INDO antibody

WB of Mouse Anti-IDO1 Antibody. Extracts from 293HEK Cells expressing: Lane 1: Control Vector. Lane 2: His-tagged mouse IDO1. Lane 3: mouse IDO1. Lane 4: His-tagged mouse IDO2. Lane 5: mouse IDO2. Lane 6: Epididymis from IDO null. Lane 7: wild type mice. Primary antibody: IDO-1(2E2) monoclonal antibody. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 1xPBST overnight at 4°C. Predicted/Observed size: 41-42 kDa/41-42 kDa for IDO-1. Other band(s): none. Mouse 2E2.6 Purified Ms E, F, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-IDO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506368) Mouse IgG1 OTI2B5 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-IDO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506378) Mouse IgG1 OTI1E11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Western Blot of Mouse Anti-IDO1 Antibody. Lane 1: untreated HeLa cells. Lane 2: IFN-r treated HeLa cells. Load: 35 µg per lane. Primary antibody: IDO 1 Antibody at 1:1000 for overnight at 4°C. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 41-42 kDa, 41-42 kDa for IDO-1. Other band(s): none. Mouse 10.1 Purified Hu, Ms E, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IDO1 / INDO antibody

Predicted band size: 45 kDa . Positive control: Placenta tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IDO1 / INDO antibody

Anti-IDO1 mouse monoclonal antibody (TA506370) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IDO1(RC206592). Mouse IgG1 OTI2A10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Anti-IDO1 mouse monoclonal antibody (TA506371) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IDO1(RC206592). Mouse IgG1 OTI4C11 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Anti-IDO1 mouse monoclonal antibody (TA506372) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IDO1(RC206592). Mouse IgG1 OTI1F1 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Anti-IDO1 mouse monoclonal antibody (TA506375) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IDO1(RC206592). Mouse IgG1 OTI3B10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-IDO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506376) Mouse IgG1 OTI4B11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

Anti-IDO1 mouse monoclonal antibody (TA506377) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IDO1(RC206592). Mouse IgG1 OTI2C2 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IDO1 / INDO antibody

IDO1 / INDO Mouse IgG3 10.1 Purified Hu, Ms C, WB
0.1 mg / €680.00
  Acris Antibodies GmbH

IDO1 / INDO (1-104) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 4D2 Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

IDO1 / INDO (C-term) antibody

AP12352PU-N INDO antibody (C-term) staining of Formalin-Fixed and Paraffin-Embedded Human lung carcinoma tissue. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IDO1 / INDO (1-19, 155-176, 359-376) antibody

IDO1 / INDO Rabbit Ig Purified Ms, Rt C, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

IDO1 / INDO antibody

IDO1 / INDO Sheep Ig Purified Hu E, F, ICC/IF, P, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

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