IFI30 / GILT antibody

Principal name

IFI30 / GILT antibody

Alternative names for IFI30 / GILT antibody

IP-30, IP30, IFI-30, Gamma-interferon-inducible lysosomal thiol reductase, Gamma-interferon-inducible protein IP-30

SwissProt ID

P13284 (Human)

Gene ID

10437 (IFI30)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of IFI30 / GILT antibody

Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is mediated enzymatically by thioredoxin. In the endocytic pathway, reduction of protein disulfide bonds is important for the generation of MHC class II-peptide complexes. This process is catalyzed by a gamma-interferon-inducible thiol reductase (GILT). GILT is synthesized as a precursor, and following delivery to MHC class II-containing compartments (MIICs), is processed to the mature form via cleavage of amino- and carboxy-terminal propeptides. A lysosomal thiol reductase, GILT, is optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. GILT is expressed constitutively in antigen-presenting cells and is induced by g-interferon in other cell types, suggesting a potentially important role in antigen processing. Additionally, T cell recognition of select exogenous and endogenous epitopes is dependent on tumor cell expression of GILT. The absence of GILT in melanomas alters antigen processing and the hierarchy of immunodominant epitope presentation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IFI30 / GILT antibody

Sample(30 ug whole cell lysate). A:Raji . 12% SDS PAGE. TA307992 diluted at 1:1000 Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IFI30 / GILT antibody

WB Suggested Anti-IFI30 Antibody; Titration: 1.0 ug/ml; Positive Control: Hela Whole Cell IFI30 is supported by BioGPS gene expression data to be expressed in HeLa Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

IFI30 / GILT antibody

IFI30 MaxPab polyclonal antibody. Western Blot analysis of IFI30 expression in human spleen. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

IFI30 / GILT antibody

Western Blot analysis of IFI30 expression in transfected 293T cell line (H00010437-T02) by IFI30 MaxPab polyclonal antibody.

Lane 1: IFI30 transfected lysate(28.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

IFI30 / GILT antibody

Western Blot analysis of IFI30 expression in transfected 293T cell line (H00010437-T02) by IFI30 MaxPab polyclonal antibody.

Lane 1: IFI30 transfected lysate(28.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

IFI30 / GILT antibody

Western Blot: IFI30 Antibody [NBP1-32466] - (30 ug whole cell lysate) A:Raji  12% SDS PAGE diluted at 1:1000 Rabbit IgG Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

IFI30 / GILT antibody

Immunohistochemistry-Paraffin: IFI30 Antibody [NBP1-83366] - Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of lymphoid cells outside reaction centra. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IFI30 / GILT (58-232, His-tag)

IFI30 / GILT Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

IFI30 / GILT (58-232, His-tag)

IFI30 / GILT Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

IFI30 / GILT

IFI30 / GILT Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

IFI30 / GILT

IFI30 / GILT Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

IFI30 / GILT

IFI30 / GILT Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

IFI30 (Human) IP-WB Antibody Pair

IFI30 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

IFI30 293T Cell Transient Overexpression Lysate(Denatured)

IFI30 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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