IFNA2 / Interferon alpha-2 antibody

Principal name

IFNA2 / Interferon alpha-2 antibody

Alternative names for IFNA2 / Interferon alpha-2 antibody

Interferon alpha-A, LeIF A, IFN-alpha 2

SwissProt ID

P01563 (Human), P01573 (Mouse), P05004 (Horse)

Gene ID

3440 (IFNA2), 493653 (IFNA7)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Functional assay (FN), Immunoprecipitation (IP), Neutralisation (NEUT)

Background of IFNA2 / Interferon alpha-2 antibody

Interferon alpha-2 (UniProt P01563; also known as IFN-alpha-2, Interferon alpha-A, LeIF A) is encoded by the IFNA2 (also known as IFNA2A, IFNA2B, IFNA2C) gene (Gene ID 3440) in human. Interferons (IFNs) are cytokines whose prouction and release by host cells are induced in the presence of pathogens (e.g. viruses, bacteria, parasites) and tumor cells. Originally named for their ability to interfere with viral replication, IFNs mediate the activate immune cells, such as natural killer cells and macrophages, and increase host defense by up-regulating antigen presentation by boosting the expression of major histocompatibility complex (MHC) antigens. More than twenty distinct IFN genes and proteins have been identified and classified into three main types. Type I IFNs (IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω) exert their function via binding IFN-α/β receptor (encoded by the IFNAR1 and IFNAR2 gene, respectively). IFN-γ is the only known type II IFN, it is released by type 1 T helper cells and binds IFN-γ receptor (encoded by the IFNGR1 and IFNGR2 gene, respectively). Type III IFNs signal through a receptor complex consisting of IL10R2 (CRF2-4) and IFNLR1 (CRF2-12).

General readings

1. Roisman,L.C., Jaitin,D.A., Baker,D.P. and Schreiber,G., et al.
Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site
2. Hardy,M.P., Owczarek,C.M., Jermiin,L.S., Ejdeback,M. and Hertzog,P.J.
Characterization of the type I interferon locus and identification of novel genes
3. Akahoshi,M., Ishihara,M., Remus,N., Uno,K., Miyake,K., Hirota,T., Nakashima,K., Matsuda,A., Kanda,M., Enomoto,T., Ohno,S.,, et al.
Association between IFNA genotype and the risk of sarcoidosis
4. Ribatti,D., Crivellato,E., Candussio,L., Vacca,A., Nico,B., Benagiano,V., Roncali,L. and Dammacco,F.
Angiogenic activity of rat mast cells in the chick embryo chorioallantoic membrane is down-regulated by treatment with recombinant human alpha-2a interferon and partly mediated by fibroblast growth factor-2
5. Chill,J.H., Nivasch,R., Levy,R., Albeck,S., Schreiber,G. and Anglister,J.
The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening
6. , Goeddel D.V., Yelverton E., Ullrich A., Heyneker H.L., Miozzari G., Holmes W., Seeburg P.H., Dull T.J., May L., Stebbing N., et al.
Human leukocyte interferon produced by E. coli is biologically active.
7. , Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W., et al.
The structure of eight distinct cloned human leukocyte interferon cDNAs.
8. , Lawn R.M., Gross M., Houck C.M., Franke A.E., Gray P.V., Goeddel D.V.
DNA sequence of a major human leukocyte interferon gene.
9. , Oliver G., Balbas P., Valle F., Soberon X., Bolivar F.
Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli.
10. , Austruy E., Bagnis C., Carbuccia N., Maroc C., Birg F., Dubreuil P., Mannoni P., Chabannon C.
A defective retroviral vector encoding human interferon alpha 2 can transduce human leukemic cell lines.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IFNA2 / Interferon alpha-2 antibody

Sample (30 ug of whole cell lysate). A: A431 . 12% SDS PAGE. TA308907 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG1 KT5 Aff - Purified Hu E
1 mg / €830.00
  Acris Antibodies GmbH

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG1 KT5 Aff - Purified Hu E
0.2 mg / €420.00
  Acris Antibodies GmbH

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG1 KT5 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG1 N39 Purified Hu E, FN, NEUT, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG1 N27 Purified Hu E, FN, NEUT, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

IFNA2 / Interferon alpha-2 antibody

Western Blot analysis of IFNA2 expression in transfected 293T cell line (H00003440-T01) by IFNA2 MaxPab polyclonal antibody.

Lane 1: IFNA2 transfected lysate(20.68 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

Western Blot analysis of IFNA2 expression in transfected 293T cell line (H00003440-T01) by IFNA2 MaxPab polyclonal antibody.

Lane 1: IFNA2 transfected lysate(21.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

Western Blot analysis of IFNA2 expression in transfected 293T cell line by IFNA2 monoclonal antibody.

Lane 1: IFNA2 transfected lysate(21.6 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2b 1F8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 3E9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 3A2 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 1D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 2E5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 2F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

Western Blot analysis of IFNA2 expression in transfected 293T cell line by IFNA2 monoclonal antibody.

Lane 1: IFNA2 transfected lysate(21.6 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1C8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 2G6 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 4F3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

Western Blot analysis of IFNA2 expression in transfected 293T cell line by IFNA2 monoclonal antibody.

Lane 1: IFNA2 transfected lysate(21.6 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 3A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IFNA2 / Interferon alpha-2 antibody

IFNA2 / Interferon alpha-2 Mouse IgG2a 1D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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