IFNB / Interferon beta antibody

Principal name

IFNB / Interferon beta antibody

Alternative names for IFNB / Interferon beta antibody

IFN-beta, IFNB1, IFB, Fibroblast interferon

SwissProt ID

P01574 (Human), P01575 (Mouse), P05012 (Horse), P70499 (Rat), Q90873 (Chick), Q9N2J0 (Felca)

Gene ID

3456 (IFNB1), 15977 (Ifnb1), 24481, 554219 (IFNB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken)

Available hosts

Mouse, Rat, Rabbit, Goat, Sheep

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Functional assay (FN), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))

Background of IFNB / Interferon beta antibody

The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50% amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.
IFNB1 has antiviral, antibacterial and anticancer activities.

General readings

1. Staeheli, P. et al. (2001) Cytokines of Birds: Conserved functions - A largely different look. J. Interferon Cytokine Res. 21: 993-1010.
2. Schwarz, H.et al. (2004) Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay. J. Interferon Cytokine Res. 24:
179-184.
3. Sick, C. et al. (1996) A family of genes coding for two serologically distinct chicken interferons J. Biol. Chem.271: 7635-7639.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IFNB / Interferon beta antibody

Western blot analysis of IFN-b in A-20 cell lysate with IFN-b antibody at 5 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IFNB / Interferon beta antibody

To detect Human IFN-beta by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Human IFN-beta. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

IFNB / Interferon beta antibody

To detect Human IFN-beta by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IFN-beta (TA328341) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human IFN-beta. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IFNB / Interferon beta antibody

Western blot analysis of extracts of HepG2 cell lines, using IFNB1 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

IFNB / Interferon beta antibody

ELISA: Interferon beta Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

IFNB / Interferon beta antibody

Formalin fixed, paraffin embedded human liver stained with Rabbit anti Human IFN beta (AP05706PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

IFNB /  Interferon beta Sheep IgG Azide Free Hu FN
20 kU / €580.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

Lung: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IFNB / Interferon beta (N-term) antibody

Western blot analysis of IFNB1 Antibody (N-term) (AP18065PU-N) in HepG2 cell line lysates (35ug/lane). IFNB1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

Direct ELISA using Biotin conjugated IFNB / Interferon beta Antibody (Cat.-No PP1230B) Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

Direct ELISA using Biotin conjugated IFNB / Interferon beta Antibody (Cat.-No PP1230B) Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

Western Blot (Reduced) using IFNB / Interferon beta antibody (Cat.-No PP1230P) Rabbit Aff - Purified Hu E, FN, P, WB
50 µg / €230.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

Western Blot (Reduced) using IFNB / Interferon beta antibody (Cat.-No PP1230P) Rabbit Aff - Purified Hu E, FN, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

IFNB /  Interferon beta Rabbit Azide Free Chk FN, IP, WB
0.5 mg / €540.00
  Acris Antibodies GmbH

IFNB / Interferon beta antibody

IFNB /  Interferon beta Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

IFNB / Interferon beta antibody

Western Blot analysis of IFNB1 expression in transfected 293T cell line (H00003456-T01) by IFNB1 MaxPab polyclonal antibody.

Lane 1: IFNB1 transfected lysate(20.57 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

IFNB / Interferon beta antibody

IFNB /  Interferon beta Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

IFNB / Interferon beta antibody

Immunoprecipitation of IFNB1 transfected lysate using anti-IFNB1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with IFNB1 MaxPab mouse polyclonal antibody (B01) (H00003456-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

IFNB / Interferon beta antibody

Western Blot analysis of IFNB1 expression in transfected 293T cell line (H00003456-T01) by IFNB1 MaxPab polyclonal antibody.

Lane 1: IFNB1 transfected lysate(22.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

IFNB / Interferon beta antibody

IFNB /  Interferon beta Mouse IgG2a BB4 Hu E, WB
0.2 mg / €560.00
  Abnova Taiwan Corp.

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