IFT74 antibody

Principal name

IFT74 antibody

Alternative names for IFT74 antibody

CCDC2, CMG1, CMG-1, Intraflagellar transport protein 74 homolog, Coiled-coil domain-containing protein 2, Capillary morphogenesis protein 1

SwissProt ID

Q8BKE9 (Mouse), Q96LB3 (Human)

Gene ID

80173 (IFT74), 67694 (Ift74)

Available reactivities

Hu (Human), Rt (Rat), Mky (Monkey), Prim (Primate), Rb (Rabbit), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Ye (Yeast)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of IFT74 antibody

Capillary morphogenesis protein 1 (CMG1) is a 600 amino acid protein and has a calculated molecular mass of 65 kD. CMG1 contains a coiled-coil domain (which shares 24% identity with myosin heavy chain sequences from various species) and several putative phosphorylation sites. Bell et al. (2001) determined that CMG1 was 1 of several transcripts upregulated by umbilical vein endothelial cells during capillary morphogenesis in 3-dimensional collagen matrices. RT-PCR detected highest expression in adult and fetal kidney and lower expression in adult heart, placenta, lung, liver, and pancreas, and in fetal heart, lung, and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus, and spleen. Transfection into epithelial tumor cells revealed targeting of fluorescent-tagged CMG1 to an intracellular vesicular compartment.

General readings

1. Momeni P et al.: Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC Neurol. 2006 Dec 13;6(1):44. PMID: 17166276
2.Boldt K et.al. Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. J Clin Invest. 2011 Jun 1;121(6):2169-80. PMID: 21606596

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IFT74 (588-600) antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Mky E, P, WB
50 µg / €425.00
  OriGene Technologies GmbH

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