IGFBP1 antibody

Principal name

IGFBP1 antibody

Alternative names for IGFBP1 antibody

IGF-binding protein 1, IGFBP-1, IBP1, IBP-1, Placental protein 12, PP12, Insulin-like growth factor-binding protein 1

SwissProt ID

P08833 (Human), P21743 (Rat), P24591 (Bovin), P47876 (Mouse), Q75ZP3 (Pig)

Gene ID

3484 (IGFBP1), 16006 (Igfbp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Enzyme Immunoassay (E), Radioimmunoassay (R), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), ELISA (capture) (E(capture)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Neutralisation (NEUT)

Background of IGFBP1 antibody

Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner.

Post translational modification of IGFBPs, including phosphorylation and proteolysis, will modify the affinities of the binding proteins for IGF and may indirectly regulate IGF actions. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IGFBP1 (156-170) antibody

Staining of Human Placenta lysate using IGFBP1 Antibody Cat.-No AP32344PU-N at 2 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

IGFBP1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using IBP1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

IGFBP1 antibody

Western blot analysis using recombinant human IGF-BP1. Lane 1: 20 ng, Lane 2: 50 ng, Lane 3:100 ng, Lane 4: 200 ng. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP1 (C-term) antibody

Anti-IGFBP1 (0.1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP1 antibody

Predicted band size: 28 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/1000-5000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IGFBP1 antibody

Western blot analysis of extracts of Mouse liver tissue lysate, using IGFBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP1 antibody

To detect hIGF-BP1 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIGF-BP1. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

IGFBP1 antibody

To detect hIGF-BP1 by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IGF-BP1 (TA328350) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIGF-BP1. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IGFBP1 (RC209268, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IGFBP1.(1:2000) Mouse IgG1 OTI6H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IGFBP1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IGFBP1 (RC209268, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IGFBP1.(1:2000) Mouse IgG1 OTI4E12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IGFBP1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-IGFBP1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808733)(1:150) Mouse IgG1 OTI6C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IGFBP1 antibody

IGFBP1 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

IGFBP1 antibody

IGFBP1 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

IGFBP1 antibody

IGFBP1 Rabbit Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

IGFBP1 antibody

IGFBP1 Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

IGFBP1 antibody

IGFBP1 Rat IgG2 12D24 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

IGFBP1 antibody

IGFBP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

IGFBP1 antibody

IGFBP1 Mouse IgG2a 2F9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IGFBP1 antibody

IGFBP1 Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

IGFBP1 antibody

IGFBP1 Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

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