IGFBP6 antibody

Principal name

IGFBP6 antibody

Alternative names for IGFBP6 antibody

IGF-binding protein 6, IGFBP-6, IBP-6, IBP6, Insulin-like growth factor-binding protein 6

SwissProt ID

P24592 (Human), P35572 (Rat), P47880 (Mouse), Q05718 (Bovin)

Gene ID

3489 (IGFBP6)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), Mky (Monkey), Sh (Sheep), Bear, Rt (Rat)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C), Neutralisation (NEUT)

Background of IGFBP6 antibody

Data show that an increase in JNK activation in the presence of NFkappaB inhibition significantly increased the expression of IGFBP6. These studies provide evidence that over expression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. Observational study of gene-disease association. (HuGE Navigator) IGFBP-6 is translocated to the nucleus with functional consequences, and different members of the IGFBP family have specific nuclear import mechanisms. Toxic effect of TCDD on osteogenesis through altering IGFBP6 gene expression in osteoblasts is reported. p38 MAPK is involved in IGFBP-6-induced IGF-independent rhabdomyosarcoma cell migration. determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation. Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. A close correlation exists between residues of the carboxyl-terminal domain of IGFBP6 undergoing conformational change in 15N NMR spectroscopy studies with those that disappeared or broadened upon insulin-like growth factor (IGF-II) binding. C-domain of IGFBP-6 consists of a thyroglobulin type 1 fold comprising an alpha-helix followed by a loop, a three-stranded antiparallel beta-sheet incorporating a second loop, and a disulfide-bonded flexible third loop. The expression of certain IGFBP is significantly altered in renal cell carcinoma. CCI-779 acts additively with IGFBP-6 to reduce rhabdomyosarcoma growth both in vitro and in vivo. may function as an antiproliferative molecule suppressing mitogenic effects of insulin-like growth factors on Malassez cells. The IGFBP-6 protein is synthesized as propeptides with a hydrophobic leader sequence, removal of which yields a mature protein composed of 3 recognizable domains of similar size. transgenic human IGFBP-6 mice may be considered a new tool for studies of the involvement of the brain IGF system in metabolism control and obesity.

General readings

Cheung C, Vesey D, Cotterill A, Douglas M, Gobe G, Nicol D, Johnson D.
Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas.
Int J Urol. 2005 Jan;12(1):17-28.
PMID: 15661050

Items 1 to 20 of 27 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IGFBP6 antibody

TA302514 (0.5µg/ml) staining of Human Adrenal Gland lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP6 (C-term) antibody

Western blot analysis of IGFBP6 Antibody (C-term) (AP17495PU-N) in CEM cell line lysates (35ug/lane). IGFBP6 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IGFBP6 (128-141) antibody

Immunohistochemistry: Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE). Goat Aff - Purified Bear, Bov, Can, Eq, Hu, Prim, Sh E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IGFBP6 antibody

IGFBP6 Rat IgG2 21D24 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

IGFBP6 antibody

IGFBP6 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

IGFBP6 antibody

Western Blot analysis of IGFBP6 expression in transfected 293T cell line (H00003489-T01) by IGFBP6 MaxPab polyclonal antibody.

Lane 1: IGFBP6 transfected lysate(26.4 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

IGFBP6 antibody

IGFBP6 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

IGFBP6 antibody

IGFBP6 MaxPab rabbit polyclonal antibody. Western Blot analysis of IGFBP6 expression in human kidney. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

IGFBP6 antibody

IGFBP6 Mouse IgG2a 1A8 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IGFBP6 antibody

293 overexpressing IGFBP6 and probed with IGFBP6 polyclonal antibody ( Cat # PAB7465 ) ( mock transfection in first lane), tested by Origene. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

IGFBP6 antibody

IGFBP6 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

IGFBP6 antibody

Western Blot: IGFBP6 Antibody [NB100-94905] - (0.5 ug/ml) staining of Human Adrenal Gland lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

IGFBP6 antibody

IGFBP6 Rat IgG2 RM0098-21D24 Purified Ms WB
0.1 mg / €450.00
  Novus Biologicals Inc.

IGFBP6 antibody

Immunohistochemistry-Paraffin: IGFBP6 Antibody [NBP1-86495] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IGFBP6

IGFBP6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

IGFBP6

IGFBP6 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.

Regular Price: 20 µg / €199.00

Special Price: 20 µg / €139.00

  OriGene Technologies, Inc.

IGFBP6

IGFBP6 Human > 95 % pure by SDS-PAGE gel and HPLC analyses. High-5 Insect cells
20 µg / €230.00
  Acris Antibodies GmbH

IGFBP6

IGFBP6 Human > 95 % pure by SDS-PAGE gel and HPLC analyses. High-5 Insect cells
5 µg / €140.00
  Acris Antibodies GmbH

IGFBP6 (28-240, His-tag)

IGFBP6 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €730.00
  Acris Antibodies GmbH

IGFBP6 (28-240, His-tag)

IGFBP6 Human Purified > 85 % by SDS - PAGE E. coli
20 µg / €300.00
  Acris Antibodies GmbH

Items 1 to 20 of 27 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn