IGFBP7 antibody

Principal name

IGFBP7 antibody

Alternative names for IGFBP7 antibody

IGF-binding protein 7, IGFBP-7, IBP7, IBP-7, IGFBP-rP1, MAC25, PSF, TAF, Insulin-like growth factor-binding protein 7, Prostacyclin-stimulating factor, PGI2-stimulating factor, Tumor-derived adhesion factor

SwissProt ID

Q16270 (Human), Q61581 (Mouse)

Gene ID

3490 (IGFBP7), 29817 (Igfbp7)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of IGFBP7 antibody

Observational study of gene-disease association. (HuGE Navigator. A genome-wide RNA-interference screening to identify genes required for an activated BRAF oncogene to block proliferation of fibroblasts and melanocytes revealed that a IGFBP7, has a central role in BRAF-mediated senescence and apoptosis. This study supports the role of IGFBP-1, -3 and -7 as potential tumour suppressor genes in human breast cancer. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Expression in tumor cells may reduce the anchorage-independent growth ability, leading to the marked loss of tumorigenicity. discovered the implication of insulin-like growth factor-binding protein-related protein 1 in endometrial physiology, which seems related to endometrial receptivity. data suggest that mac25/IGFBP-rP1 and 25.1 may play a functional role in the NE differentiation of NSCLC cell lines and may provide a novel therapeutic target for treating lung cancers, in particular NSCLC with NE differentiation. findings show for the first time that circulating IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) is increased with insulin resistance. that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. mRNA expression was lost in six out of eight CRC cell lines as compared to normal colon cells. DNA methylation was found in the region of exon 1 and intron 1 of IGFBP-7. tumor-suppressive activity is through induction of apoptosis in an IGF-I independent manner in prostate cancer. SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation. In prostate cancer cells, one of the downstream mediators of the senescence-associated tumor suppression effect of mac25/IGFBP-rP1 is superoxide dismutase 2

General readings

Akaogi K., et al (1994). Biochem. Biophys. Res. Commun. 198:1046-1053
Oh Y., et al (1996). J. Biol. Chem. 271:30322-30325

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IGFBP7 (145-159) antibody

(1ug/ml) staining of Mouse Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP7 antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and ovarian cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human colon and ovarian cancer tissue using IGFBP7 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

IGFBP7 antibody

Predicted band size: 29 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IGFBP7 antibody

To detect hIGF-BP7 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIGF-BP7. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

IGFBP7 antibody

To detect hIGF-BP7 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IGF-BP7 (TA328354) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIGF-BP7. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IGFBP7 antibody

IGFBP7 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

IGFBP7 antibody

IGFBP7 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

IGFBP7 antibody

This antibody stained HeLa and U-251 MG cells. The primary antibody was incubated at 2.0 µg/ml overnight at 4°C followed by a fluorescent labeled secondary antibody. Optimal concentrations and conditions may vary. Information and photo are courtesy of the Cell Profiling group, SciLifeLab Stockholm. Rabbit Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

IGFBP7 antibody

This antibody stained HeLa and U-251 MG cells. The primary antibody was incubated at 2.0 µg/ml overnight at 4°C followed by a fluorescent labeled secondary antibody. Optimal concentrations and conditions may vary. Information and photo are courtesy of the Cell Profiling group, SciLifeLab Stockholm. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

IGFBP7 antibody

IGFBP7 Goat Bov, Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

IGFBP7 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IBP7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

IGFBP7 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IBP7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

IGFBP7 antibody

Human Muscle; WB Suggested Anti-IGFBP7 Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Muscle; IGFBP7 antibody - C-terminal region (ARP48174_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

IGFBP7 antibody

ELISA: IGFBP7 Antibody [29790002] Rabbit Hu E, P
50 µg / €470.00
  Novus Biologicals Inc.

IGFBP7 antibody

IGFBP7 Goat Aff - Purified Ms E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

IGFBP7 antibody

Immunohistochemistry-Paraffin: IGFBP7 Antibody [NBP1-83415] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IGFBP7

IGFBP7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

IGFBP7

IGFBP7 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 25 µg / €199.00

Special Price: 25 µg / €139.00

  OriGene Technologies, Inc.

IGFBP7

IGFBP7 Human > 98 % pure by SDS-PAGE gel and HPLC analyses. E. coli
25 µg / €230.00
  Acris Antibodies GmbH

IGFBP7

IGFBP7 Human > 98 % pure by SDS-PAGE gel and HPLC analyses. E. coli
5 µg / €140.00
  Acris Antibodies GmbH

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