IL18BP antibody

Principal name

IL18BP antibody

Alternative names for IL18BP antibody

Interleukin-18-binding protein, IL-18BP, Tadekinig-alfa

SwissProt ID

O95998 (Human), Q9Z0M9 (Mouse)

Gene ID

16068 (Il18bp), 10068 (IL18BP)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of IL18BP antibody

IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells.
This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.

General readings

Shimizu,C., et al. (2012) Mod Rheumatol 22 (1), 73-79Fujita,T.,et al. (2011) Diabetes Res. Clin. Pract. 92 (3), E66-E69

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IL18BP antibody

  Rabbit polyclonal anti-IL18BP antibody  
Western blot analysis of extracts from HepG2 and HeLa cells, using IL18BP antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL18BP antibody

  Anti-IL18BP Rabbit Polyclonal Antibody  
Gel: 10%SDS-PAGE, Lysate: 60 µg, Lane: Human lymphoma tissue, Primary antibody: IL18BP Antibody at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL18BP antibody

  Anti-IL18BP Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using IL18BP antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL18BP antibody

  Rabbit Polyclonal IL-18 BPa/IL18BP Antibody  
Western Blot: IL18BP Antibody [TA336593] - WB detection of IL18BP in the lysate of spleen tissue with TA336593 at a dilution of 1:500 Rabbit Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL18BP antibody

  Mouse Monoclonal IL18 binding protein Antibody  
Western blot detection of IL18 binding protein in CHO-K1 cells transfected by IL18BP-PDGFR fusion protein and K562 cell lysates using IL18 binding protein mouse mAb (1:400-1:1000 diluted).Predicted band size:37KDa.Observed band size:37/40KDa. Mouse IgG2b 5C7-D2-G4-B6 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL18BP antibody

IL18BP Goat Biotin Ms E, WB
25 µg / €230.00
  Acris Antibodies GmbH

IL18BP antibody

IL18BP Goat Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

IL18BP antibody

IL18BP Goat Aff - Purified Ms E, WB
50 µg / €220.00
  Acris Antibodies GmbH

IL18BP antibody

IL18BP Goat Aff - Purified Ms E, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

IL18BP - human gene knockout kit via CRISPR

IL18BP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

IL18BP - human gene knockout kit via CRISPR

IL18BP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL18BP - human gene knockout kit via CRISPR

IL18BP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL18BP - human gene knockout kit via CRISPR

IL18BP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il18bp - mouse gene knockout kit via CRISPR

Il18bp - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Il18bp - mouse gene knockout kit via CRISPR

Il18bp - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il18bp - mouse gene knockout kit via CRISPR

Il18bp - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il18bp - mouse gene knockout kit via CRISPR

Il18bp - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IL18BP (transcript variant A)

  Purified recombinant protein of Human interleukin 18 binding protein (IL18BP), transcript variant A  
IL18BP Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
50 µg / €139.00
  OriGene Technologies, Inc.

IL18BP (31-194, His-tag)

IL18BP Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

IL18BP (31-194, His-tag)

IL18BP Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

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