IL1RL1 / ST2 antibody

Principal name

IL1RL1 / ST2 antibody

Alternative names for IL1RL1 / ST2 antibody

Interleukin-1 receptor-like 1, DER4, FIT-1, MGC32623, Homolog of mouse growth stimulation-expressed

SwissProt ID

P14719 (Mouse), Q01638 (Human), Q62611 (Rat)

Gene ID

17082 (Il1rl1), 9173 (IL1RL1), 25556

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Can (Canine)

Available hosts

Rat, Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of IL1RL1 / ST2 antibody

The ST2 gene, also known as T1, Fit1, or DER4, was originally identified as a responsive gene that was highly induced by stimulation of various proliferation-inducing agents including serum, PDGF (platelet-derived growth factor), FGF (fibroblast growth factor), or lysophosphatidic acid in murine fibroblasts. Three distinct forms of gene products have been reported and named ST2, ST2V, and ST2L. ST2 is a soluble secreted form of a 37 kDa protein, which lacks an intracellular domain, whereas ST2L is a transmembrane form of a 62 kDa protein (the glycosylated forms of ST2 and ST2L are about 57 and 80 kDa, respectively). This ST2L protein is very similar to IL-1R (interleukin-1 receptor) type I and II in structure, thus it is considered a member of the IL-1R family. ST2V, which is another novel variant form of human ST2, has been identified recently. ST2 proteins are expressed in a several types of human cells, including hematopoietic cells in various stages of differentiation, a population of the peripheral blood mononuclear cells from healthy individuals, glioblastoma and astrocytoma cell lines, and colon cancer cells in addition to fibroblast cell lines. Thus ST2 proteins are considered to have some roles in regulating cell growth or proliferation. On the other hand, either definitive functions of ST2 proteins or their ligand molecule(s) which bind to ST2 proteins have remained unclear, though it has been reported that IL-1a, ß, and RA (receptor antagonist) do not bind to ST2 proteins in spite of their structural similarity to IL-1R. This indicates that the ST2L protein is functionally independent from IL-1R. Furthermore, several studies have shown that ST2L is expressed on the cell surface of Th2 cells but not on Th1 cells, indicating the possibility that the ST2L protein participates not only in the regulation of cell growth or proliferation, but also in the immune system including differentiation of T cells or immunological response via helper T cells. From these observations, ST2 proteins are considered to be one of the important proteins that participate in various physiological phenomenon, thus further analysis is required to understand its physiological functions.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IL1RL1 / ST2 (N-term) antibody

  Rabbit Polyclonal ST2 Antibody  
Western blot analysis of ST2 in mouse kidney lysate with ST2 antibody at 1 ug/ml in the presence (lane A) or absence (lane B) of 1 ug blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL1RL1 / ST2 antibody

  Anti-IL1RL1 Rabbit Polyclonal Antibody  
Predicted band size: 37 kDa . Positive control: Human fetal intestine tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL1RL1 / ST2 antibody

  Anti-IL1RL1 Rabbit Polyclonal Antibody  
Predicted band size: 37 kDa . Positive control: Human fetal kidney and intestine tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 10%SDS-PAGE Lane1: Human fetal kidney tissue lysate Lane2: Human fetal intestine tissue lysate Lysates: 40 ug per lane Primary antibody: 1/1100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL1RL1 / ST2 antibody

  Rabbit Polyclonal IL1RL1 Antibody  
Western Blot: IL1RL1 Antibody [TA337037] - Analysis of IL1RL1 in Daudi cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) NIH 3T3 using TA337037 at 5 ug/ml and 3 ug/ml, respectively. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL1RL1 / ST2 antibody

  Rabbit Polyclonal Anti-IL1RL1 Antibody  
WB Suggested Anti-IL1RL1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human brain Rabbit IgG Purified Can, Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

IL1RL1 / ST2 antibody

Flow cytometric analysis of human ST2 expression on transfectant (right) and parental cells (left). Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26439AF to the cells. Mouse IgG1 HB12 Azide Free Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

IL1RL1 / ST2 antibody

Flow cytometric analysis of human ST2 expression in transfectant. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26440AF-N to the cells. Mouse IgG1 FB9 Azide Free Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

IL1RL1 / ST2 antibody

Flow cytometric analysis of human ST2 expression in transfectant. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26441AF-N to the cells. Mouse IgG1 2A5 Azide Free Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

IL1RL1 / ST2 antibody

Flow cytometric analysis of human ST2 expression in transfectant. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26441FC-N to the cells. Mouse IgG1 2A5 FITC Hu F
100 µl / €390.00
  Acris Antibodies GmbH

IL1RL1 / ST2 antibody

Flow cytometric analysis of human ST2 expression on T98G parental cells (left) and HST2L-4-2 ST2L transfectant (right). Open histogram indicates the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26441RP-S to the cells. Mouse IgG1 2A5 PE Hu F
1.0 ml / €390.00
  Acris Antibodies GmbH

IL1RL1 / ST2 (Extracell. Dom.) antibody

IL1RL1 / ST2 Rat IgG2 3F22 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

IL1RL1 - human gene knockout kit via CRISPR

IL1RL1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

IL1RL1 - human gene knockout kit via CRISPR

IL1RL1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL1RL1 - human gene knockout kit via CRISPR

IL1RL1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL1RL1 - human gene knockout kit via CRISPR

IL1RL1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il1rl1 - mouse gene knockout kit via CRISPR

Il1rl1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Il1rl1 - mouse gene knockout kit via CRISPR

Il1rl1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il1rl1 - mouse gene knockout kit via CRISPR

Il1rl1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il1rl1 - mouse gene knockout kit via CRISPR

Il1rl1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IL1RL1 / ST2 (transcript variant 2)

  Purified recombinant protein of Human interleukin 1 receptor-like 1 (IL1RL1), transcript variant 2  
IL1RL1 / ST2 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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