IL1RN / IL1RA antibody

Principal name

IL1RN / IL1RA antibody

Alternative names for IL1RN / IL1RA antibody

IL1F3, IL-1ra, IL-1RN, IRAP, IL1 inhibitor, ICIL-1RA, Interleukin-1 receptor antagonist protein

SwissProt ID

O18999 (Horse), O77482 (Bovin), P18510 (Human), P25085 (Mouse), P25086 (Rat), P26890 (Rabit), Q29056 (Pig), Q9BEH0 (Canfa)

Gene ID

3557 (IL1RN), 16181 (Il1rn), 60582

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Functional assay (FN), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair)

Background of IL1RN / IL1RA antibody

The interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring molecule that shares homology with IL-1α and IL-1β. It binds competitively to IL-1 receptors Type I and Type II with the same affinity as does IL-1, but does not induce any intracellular response. Two structural variants of IL-1Ra have been described: a 17 kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18-kDa form that remains in the cytoplasm of keratinocytes and other epithelial cells, monocytes, and fibroblasts (icIL-1Ra). An additional 16-kDa intracellular isoform of IL-1Ra has recently been described in neutrophils, monocytes, and hepatic cells. Both of the major isoforms of IL-1Ra are transcribed from the same gene through the use of alternative first exons. The production of IL-1Ra is stimulated by many substances including adherent IgG, other cytokines, and bacterial or viral components. The tissue distribution of IL-1Ra in mice indicates that sIL-1Ra is found predominantely in peripheral blood cells, lungs, spleen, and liver, while icIL-1Ra is found in large amounts in skin. Studies in transgenic and knockout mice indicate that IL-1Ra is important in host defense against endotoxin-induced injury. IL-1Ra is produced by hepatic cells with the characteristics of an acute phase protein. Endogenous IL-1Ra is produced in numerous experimental animal models of diesease as well as in human autoimmune and chronic inflammatory diseases. The use of neutralizing anti-IL-1Ra antibodies has demonstrated that endogenous IL-1Ra is an important natural antiinflammatory protein in arthritis, colitis, and granulomatous pulmonary disease.

General readings

Capper., et al. (2004) Clin. Exp. Immunol. 138:348 Roberge CJ., et al. (1994) Journal of Immunology. 152: 5485-94 Carter DB., et al. (1990) Nature. 344: 633-7

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IL1RN / IL1RA antibody

IL1 Receptor antagonist antibody detects IL1RN protein by Western blot analysis. A. 30 ug Raji whole cell lysate/extract. 15 % SDS-PAGE. IL1 Receptor antagonist antibody (TA308778) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

Western blot analysis of extracts of various cell lines, using IL1RN antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-IL1RN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA803396) Mouse IgG2b OTI3B1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-IL1RN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803422) Mouse IgG2b OTI2B1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

Western blot analysis of IL1RN (arrow) using rabbit polyclonal IL1RN Antibody (Center) (Cat. #TA324842). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IL1RN gene (Lane 2) (Origene Technologies). Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

To detect Human IL-1RA by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Human IL-1RA. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

To detect Human IL-1RA by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-1RA (TA328202) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human IL-1RA. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC218518, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC218518, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC202447, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Mouse IgG2b OTI2D9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC202447, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Mouse IgG2a OTI2D5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC202447, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Mouse IgG2a OTI5C5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC202447, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Mouse IgG1 OTI2D2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN (RC202447, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1RN. Mouse IgG1 OTI4E8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IL1RN / IL1RA antibody

IL1RN /  IL1RA Mouse IgG1 AS17 FITC Hu F
100 Tests / €360.00
  Acris Antibodies GmbH

IL1RN / IL1RA antibody

IL1RN /  IL1RA Mouse IgG1 KT6 Aff - Purified Hu E
1 mg / €910.00
  Acris Antibodies GmbH

IL1RN / IL1RA antibody

IL1RN /  IL1RA Mouse IgG1 KT6 Aff - Purified Hu E
0.2 mg / €450.00
  Acris Antibodies GmbH

IL1RN / IL1RA antibody

IL1RN /  IL1RA Mouse IgG1 KT6 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

IL1RN / IL1RA (IL-1ra3) antibody

IL1RN /  IL1RA Mouse IgG1 2D11 Purified Hu C, E, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

IL1RN / IL1RA antibody

IL1RN /  IL1RA Rabbit IgG Biotin Hu E
0.2 mg / €360.00
  Acris Antibodies GmbH

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