Inhibin alpha / INHA antibody

Principal name

Inhibin alpha / INHA antibody

SwissProt ID

P04087 (Pig), P05111 (Human), P07994 (Bovin), P17490 (Rat), P43031 (Chick), P55101 (Horse), Q04997 (Mouse)

Gene ID

3623 (INHA), 16322

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine), Ft (Ferret), Eq (Equine), Gt (Goat), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P), Dot blot (Dot), ELISA (detection) (E(detection))

Background of Inhibin alpha / INHA antibody

Inhibin and Activin are peptides structurally related to the transforming growth factor-β (TGF-β) superfamily of proteins that binds to transmembrane receptor proteins with serine threonine kinase activity and the interacting proteins like SMAD2, 3 and 4. Inhibins are heterodimeric glycoproteins composed of an α-subunit and one of several forms of β-subunits (e.g. βA or βB), resulting in biologically active forms termed inhibin A and inhibin B. Inhibin is a gonadal hormone capable of preferential suppression of pituitary follicle-stimulating hormone (FSH) secretion. The major form of this hormone, inhibin is an alpha beta heterodimer encoded by two separate genes. In contrast to the alpha/beta heterodimer of inhibin, the beta beta homodimer stimulate FSH secretion. There exist a closed-loop feedback axis between Luteinizing hormone secreting pituitary cells and gonadol-androgen producing cells which is modulated by inhibin. It has been shown that FSH stimulation of inhibin biosynthesis by ovarian granulosa and testis Sertoli cells, an additional closed-loop feedback axis exists between pituitary FSH- and gonadal inhibin-producing cells (1). The expression of Inhibin was found in gonadal and extragonadal tissues, mainly the alfa, alfa/beta and beta/beta subunit were expressed in ovary, testis, placenta, pituitary, adrenal, bone marrow, kidney, spinal cord and brain (2). The expression of inhibin subunit may vary by several fold in a tissue specific manner. The alfa subunit levels are higher in gonads while the beta subunits are abundant in bone marrow and placenta (2). In testis the alfa subunit decrease with maturation suggesting the dimmers play some role in spermatogenesis, maturation and development of testis. The current literature suggests that activin and inhibin function also as local autocrine/paracrine regulators in the gonads.
Inhibin, a dimeric 32 kDa peptide hormone composed of an α subunit and a β subunit and is produced by ovarian granulosa and theca cells. The alpha chain is a 366 amino acid protein which is conserved in several species. Inhibin is used as a marker for diagnosis of Sarcomatoid adult granulosa cell tumor, it is believed to be a better marker than calretinin and is routinely used for diagnostic purposes (3).

General readings

Knight, P.G. (1996) Front. Neuroendocrinol. 17: 476-509.Mather, J.P., et al. (1997). Proc. Soc. Exp. Biol. Med. 215: 209-222.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Inhibin alpha / INHA (N-term) antibody

Human Testis stained with Anti-Inhibin alpha Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Inhibin alpha / INHA (N-term) antibody

Human Testis stained with Anti-Inhibin alpha Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Inhibin alpha / INHA (N-term) antibody

Human Testis stained with Anti-Inhibin alpha Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Predicted cell location: Cytoplasm. Positive control: Human tonsil tissue. Recommended dilution: 1/150-300  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using INHA antibody at dilution 1/120, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Inhibin alpha / INHA antibody

Predicted cell location: Cytoplasm. Positive control: Human tonsil and renal cancer tissue. Recommended dilution: 1/150-500  The image on the left is immunohistochemistry of paraffin-embedded human tonsil tissue using INHA antibody at dilution 1/150, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Inhibin alpha / INHA antibody

Immunohistochemistry staining of Paraffin Adrenal cortex tissue by Inhibin, alpha antibody (dilution: 1:5 - 1:100; visualization of staining: Cytoplasmic) Mouse IgG2a R1 Purified Hu P
1 ml / €470.00
  OriGene Technologies, Inc.

Inhibin alpha / INHA antibody

WB Suggested Anti-INHA Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Por, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Inhibin alpha / INHA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY INHA (RC202819, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-INHA. Mouse IgG1 OTI12F11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Inhibin alpha / INHA antibody

Formalin-Fixed Paraffin-Embedded Human Placenta stained with INHA Antibody Cat.-No AM06008PU-N at 1/1000 dilution after heat-induced antigen retrieval. Mouse IgG1 Purified Hu C, E, F, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Immunohistochemical analysis of paraffin-embedded human lymphoid (A), ovary tumor (B) and testicle tumor (C) tissues using INHA antibody Cat.-No AM06151PU-N with DAB staining. Mouse IgG1 4A2 Purified Hu ICC/IF, P
0.1 ml / €360.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Immunofluorescence analysis of PANC-1 cells using INHA antibody Cat.-No AM06527SU-N (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Mouse IgG1 4E2 Ascites Hu, Ms E, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Formalin-Fixed, Paraffin-Embedded Human corpus luteum stained with Inhibin antibody Cat.-No. AM10098SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of luteal cells. Mouse IgG2a R1 Supernatant Bov, Hu P
1 ml / €600.00
  Acris Antibodies GmbH

Inhibin alpha / INHA control peptide

Inhibin alpha / INHA
0.25 mg / €250.00
  Acris Antibodies GmbH

Inhibin alpha / INHA (18-23) antibody

Western blot with AP10115PU-N (1:500) Rabbit Aff - Purified Hu, Ms, Rt C, Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Inhibin alpha / INHA (N-term) antibody

Western blot analysis of INHA (arrow) using rabbit polyclonal INHA Antibody (N-term) (AP17507PU-N). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INHA gene (Lane 2) (Origene Technologies). Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu P
50 µl / €470.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Inhibin alpha / INHA Rabbit IgG Purified Hu C, E, P
1 ml / €410.00
  Acris Antibodies GmbH

Inhibin alpha / INHA antibody

Inhibin alpha / INHA Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Inhibin alpha / INHA antibody

Inhibin alpha / INHA Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Inhibin alpha / INHA antibody

Inhibin alpha / INHA Mouse IgG2a 3B7 Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

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