INPP5D antibody

Principal name

INPP5D antibody

Alternative names for INPP5D antibody

SHIP, SHIP1, SHIP-1, p150Ship, SIP-145, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, SH2 domain-containing inositol-5'-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa

SwissProt ID

P97573 (Rat), Q6P4S2 (Xenla), Q92835 (Human), Q9ES52 (Mouse), Q9JLG0 (Mouse)

Gene ID

3635 (INPP5D), 16331 (Inpp5d)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of INPP5D antibody

The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a 170 kDa glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 -tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

INPP5D antibody

  Rabbit polyclonal anti-SHIP antibody  
Western blot analysis of extracts from Jurkat cells, treated with PMA (1ng/ml, 15mins), using SHIP antibody (#TA312856).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

INPP5D antibody

  Rabbit Polyclonal Anti-SHIP1 Antibody  
Western blot analysis on HepG2 cell lysate using SHIP1 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

INPP5D antibody

Western Blotting analysis (reducing conditions) of human SHIP-1 in whole cell lysate of THP-1 human acute monocytic leukemia cell line.
Lane 1: immunostaining with Isotype mouse IgG1 control (PPV-04; AM03096PU-N). Lane 2,3: immunostaining with anti-human SHIP-1 (SHIP-01; AM03030PU-N). Lane 4,5: immunostaining with anti-human SHIP-1 (SHIP-02; AM03031PU-N). Mouse IgG2a SHIP-01 Aff - Purified Hu E, WB
0.1 mg / €230.00
  Acris Antibodies GmbH

INPP5D antibody

Western Blotting analysis (reducing conditions) of human SHIP-1 in whole cell lysate of THP-1 human acute monocytic leukemia cell line. Lane 1: immunostaining with Isotype mouse IgG1 control (PPV-04; AM03096PU-N). Lane 2,3: immunostaining with anti-human SHIP-1 (SHIP-01; AM03030PU-N). Lane 4,5: immunostaining with anti-human SHIP-1 (SHIP-02; AM03031PU-N). Mouse IgG2a SHIP-02 Aff - Purified Hu E, WB
0.1 mg / €230.00
  Acris Antibodies GmbH

INPP5D antibody

Western blot (WB) analysis of SHIP1 antibody (Cat.-No.: AP06313PU-N) in extracts from HuvEc cells. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

INPP5D antibody

Western blot (WB) analysis of SHIP1 antibody (Cat.-No.: AP06581PU-N) in extracts from mouse brain. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

INPP5D (Center) antibody

Western blot analysis of INPP5D (arrow) using rabbit polyclonal INPP5D Antibody (Center) (Cat.#AP12504PU-N). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

INPP5D (C-term) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt P
0.25 ml / €470.00
  Acris Antibodies GmbH

INPP5D pTyr1021 antibody

Western blot analysis of extracts from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

INPP5D pTyr1021 antibody

Western blot analysis of extracts from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

INPP5D antibody

Western blot analysis of extracts from mouse brain cells, using SHIP1 (Ab-1020) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

INPP5D antibody

Western blot analysis of extracts from mouse brain cells, using SHIP1 (Ab-1020) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

INPP5D antibody

Western blot analysis of extracts from HuvEc cells, using SHIP1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

INPP5D antibody

Western blot analysis of extracts from HuvEc cells, using SHIP1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Inpp5d - mouse gene knockout kit via CRISPR

Inpp5d - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Inpp5d - mouse gene knockout kit via CRISPR

Inpp5d - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Inpp5d - mouse gene knockout kit via CRISPR

Inpp5d - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Inpp5d - mouse gene knockout kit via CRISPR

Inpp5d - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

INPP5D (transcript variant 2)

  Recombinant protein of human inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2  
INPP5D Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

INPP5D overexpression lysate

INPP5D overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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