INPPL1 antibody

Principal name

INPPL1 antibody

Alternative names for INPPL1 antibody

INPPL-1, SHIP2, SHIP-2, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, SH2 domain-containing inositol-5'-phosphatase 2

SwissProt ID

O15357 (Human), Q6P549 (Mouse), Q9WVR3 (Rat)

Gene ID

3636 (INPPL1)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of INPPL1 antibody

INPPL1 is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways with wide reaching effects It plays a central role in regulation of PI3K-dependent insulin signaling and confers resistance to dietary obesity. It is part of a signaling pathway that regulates actin cytoskeleton remodeling. It regulates cell adhesion and cell spreading and acts as a regulator of neuritogenesis. It acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). and mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. It is involved in the EGF signaling pathway.Cytoplasm: cytosol and cytoskeleton; actin patch. Membrane; Peripheral membrane protein. Note: Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

INPPL1 antibody

INPPL1 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

INPPL1 antibody

INPPL1 monoclonal antibody (M01), clone 3E6 Western Blot analysis of INPPL1 expression in HeLa ( Cat # L013V1 ). Mouse IgG1 3E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

INPPL1 antibody

INPPL1 Mouse IgG1 10G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

INPPL1 antibody

INPPL1 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

INPPL1 antibody

Confocal immunofluorescent analysis of HeLa cells labeled with SHIP2 Antibody (left, green) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).  Rabbit Aff - Purified Hu, Rt F, ICC/IF, IP, WB
0.1 ml / €410.00
  Neuromics Antibodies

INPPL1 antibody

Immunohistochemistry-Paraffin: INPPL1 Antibody [NB100-1592] - Please see notes section Rabbit Aff - Purified Hu IP, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

INPPL1 antibody

Immunohistochemistry-Paraffin: INPPL1 Antibody [NBP1-87046] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

INPPL1

INPPL1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

INPPL1

INPPL1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

INPPL1 overexpression lysate

INPPL1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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