INSIG1 antibody

Principal name

INSIG1 antibody

Alternative names for INSIG1 antibody

INSIG-1, Insulin-induced gene 1 protein

SwissProt ID

A0JNC3 (Bovin), O15503 (Human), Q08755 (Rat), Q5ZMT9 (Chick), Q6DF80 (Xenla)

Gene ID

3638 (INSIG1), 64194 (Insig1)

Available reactivities

Hu (Human), Bov (Bovine), Hst (Hamster), Ms (Mouse), Rt (Rat), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Gt (Goat), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of INSIG1 antibody

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

General readings

Roth,A., (2008) Mol. Pharmacol. 73 (4), 1282-1289

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

INSIG1 antibody

  Rabbit Polyclonal Antibody against Insig1  
Detection of Insig 1 in HepG2 lyaste Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

INSIG1 antibody

  Rabbit polyclonal anti-Insig1 antibody  
Western blot analysis of InSig1 expression in Jurkat cell lysate. Rabbit Purified Bov, Hst, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

INSIG1 antibody

  Rabbit Polyclonal Anti-INSIG1 Antibody  
WB Suggested Anti-INSIG1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Spleen Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

INSIG1 antibody

  Rabbit Polyclonal Anti-INSIG1 Antibody  
WB Suggested Anti-INSIG1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human brain Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

INSIG1 antibody

  Rabbit Polyclonal Anti-INSIG1 Antibody  
INSIG1 Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

INSIG1 - human gene knockout kit via CRISPR

INSIG1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

INSIG1 - human gene knockout kit via CRISPR

INSIG1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

INSIG1 - human gene knockout kit via CRISPR

INSIG1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

INSIG1 - human gene knockout kit via CRISPR

INSIG1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, INSIG1 (mGFP-tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, INSIG1 (mGFP-tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, INSIG1 (mGFP-tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, INSIG1 (mGFP-tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, INSIG1 (Myc-DDK tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, INSIG1 (Myc-DDK tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Lenti ORF particles, INSIG1 (Myc-DDK tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, INSIG1 (Myc-DDK tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Insig1 (GFP-tagged ORF) - Rat insulin induced gene 1 (Insig1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Insig1 (GFP-tagged ORF) - Rat insulin induced gene 1 (Insig1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Insig1 (Myc-DDK-tagged ORF) - Rat insulin induced gene 1 (Insig1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Insig1 (Myc-DDK-tagged ORF) - Rat insulin induced gene 1 (Insig1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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