INSIG2 antibody

Principal name

INSIG2 antibody

Alternative names for INSIG2 antibody

INSIG-2, Insulin-induced gene 2 protein

SwissProt ID

Q66J27 (Xenla), Q6PQZ3 (Pig), Q80UA9 (Rat), Q91WG1 (Mouse), Q9Y5U4 (Human)

Gene ID

51141 (INSIG2), 72999 (Insig2), 288985

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Can (Canine), Eq (Equine), Gt (Goat), Rb (Rabbit), Sh (Sheep), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of INSIG2 antibody

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated sigling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Li,C.G., (2008) Int. J. Cancer 123 (2), 273-282

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