INSIG2 antibody

Principal name

INSIG2 antibody

Alternative names for INSIG2 antibody

INSIG-2, Insulin-induced gene 2 protein

SwissProt ID

Q66J27 (Xenla), Q6PQZ3 (Pig), Q80UA9 (Rat), Q91WG1 (Mouse), Q9Y5U4 (Human)

Gene ID

51141 (INSIG2), 72999 (Insig2), 288985

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Can (Canine), Eq (Equine), Gt (Goat), Rb (Rabbit), Sh (Sheep), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of INSIG2 antibody

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated sigling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Li,C.G., (2008) Int. J. Cancer 123 (2), 273-282

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

INSIG2 antibody

  Rabbit Polyclonal Anti-INSIG2 Antibody  
WB Suggested Anti-INSIG2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €360.00
  OriGene Technologies, Inc.

INSIG2 antibody

  Rabbit Polyclonal Anti-INSIG1 Antibody  
WB Suggested Anti-INSIG1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

INSIG2 antibody

  Rabbit Polyclonal Anti-INSIG2 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (INSIG2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

INSIG2

  Recombinant protein of human insulin induced gene 2 (INSIG2)  
INSIG2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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