Insulin-like growth factor II / IGF2 antibody

Principal name

Insulin-like growth factor II / IGF2 antibody

Alternative names for Insulin-like growth factor II / IGF2 antibody

IGF-II, Somatomedin-A

SwissProt ID

P01344 (Human), P01346 (Rat), P07456 (Bovin), P09535 (Mouse), P10764 (Sheep), P23695 (Pig), P33717 (Chick), P51459 (Horse), Q08279 (Cavpo)

Gene ID

16002 (Igf2), 3481 (IGF2), 24483

Available reactivities

Ms (Mouse), Hu (Human), Bov (Bovine), Rt (Rat), Can (Canine), Por (Porcine)

Available hosts

Goat, Rabbit, Mouse, Rat

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Neutralisation (NEUT), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Insulin-like growth factor II / IGF2 antibody

Insulin-like Growth Factor II (IGFII) was first isolated from human serum by Froesch, et al., as a factor displaying insulin like activities that were not suppressed by antibodies to insulin. It had been discovered that growth hormone dependent factors in serum stimulate the incorporation of 35S into cartilage and that calf serum factors induced cellular division in chick fibroblasts. In 1972, the term ""somatomedin"" was introduced in an unsuccessful attempt to unify the nomenclature of these hormone-dependent factors. In 1987, a consensus among an international group of scientists endorsed the use of the terms insulin like growth factors (IGFI and IGFII), originally proposed by Rinderknecht and Humbel. Hence, IGFI and IGFII have had several synomyms: nonsuppressible insulin like activity (NSIL-A), sulfation factor activity (SFA), and multiplication stimulating activity (MSA). Because IGFII was not regulated by growth hormone, only IGFI was known as a somatomedin. Human IGFII contains 67 amino acids and shares similar structural features with IGFI, including a 62% sequence homology. In human plasma, IGFI and IGFII are associated with IGF-binding proteins that transport the polypeptides and partially regulate their actions in vivo. In addition to the insulin receptor, IGFII binds to two forms of IGF receptors, both of which are widely distributed in different tissues and cultured cells. IGFII is mitogenic for a variety of cultured cells, including mouse 3T3 cells,12 normal rat kidney cells, human or chicken fibroblasts and MCF-7 human breast carcinoma cells.

General readings

Pedersen S.K., et al. (2002). Biochem. J. 363: 37-44.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Insulin-like growth factor II / IGF2 antibody

Western blot analysis of extracts of various cell lines, using IGF2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Insulin-like growth factor II / IGF2 antibody

To detect hIGF-II by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIGF-II. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Insulin-like growth factor II / IGF2 antibody

To detect hIGF-II by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IGF-II (TA328348) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIGF-II. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Serum Bov, Hu WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Serum Bov, Hu WB
20 µl / €150.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 (81-93) antibody

Staining of paraffin embedded Human Cerebellum using IGF2 Antibody Cat.-No AP33296PU-N at 5 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, P
0.1 mg / €340.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 (Center) antibody

Formalin fixed and paraffin embedded human placenta tissue stained with IGF2 Antibody Cat.-No AP52163PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rat IgG2 3J42 Purified Hu, Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Aff - Purified Hu E, FN, P, WB
50 µg / €230.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Aff - Purified Hu E, FN, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Insulin-like growth factor II / IGF2 antibody

Western Blot analysis of IGF2 expression in transfected 293T cell line (H00003481-T02) by IGF2 MaxPab polyclonal antibody.

Lane 1: IGF2 transfected lysate(19.8 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Insulin-like growth factor II / IGF2 antibody

Western Blot analysis of IGF2 expression in transfected 293T cell line (H00003481-T02) by IGF2 MaxPab polyclonal antibody.

Lane 1: IGF2 transfected lysate(20.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Goat Aff - Purified Ms P
50 µg / €590.00
  Novus Biologicals Inc.

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rabbit Serum Ms, Rt P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II / IGF2 Rat IgG2 RM0100-3J42 Purified Hu, Ms WB
0.2 mg / €450.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Insulin-like growth factor II / IGF2 (transcript variant 1)

Insulin-like growth factor II / IGF2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 50 µg / €199.00

Special Price: 50 µg / €139.00

  OriGene Technologies, Inc.

Insulin-like growth factor II / IGF2 (transcript variant 2)

Insulin-like growth factor II / IGF2 Mouse > 98 %
Preparation: .
Purity Detail: >98%, as determined by Coomassie stained SDS-PAGE.
E. coli

Regular Price: 25 µg / €119.00

Special Price: 25 µg / €99.00

  OriGene Technologies, Inc.

Insulin-like growth factor II / IGF2 (25-91)

Insulin-like growth factor II / IGF2 Human Purified > 90 % E. coli
0.25 mg / €1,000.00
  Acris Antibodies GmbH

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