Insulin-like growth factor II / IGF2 antibody

Principal name

Insulin-like growth factor II / IGF2 antibody

Alternative names for Insulin-like growth factor II / IGF2 antibody

IGF-II, Somatomedin-A

SwissProt ID

P01344 (Human), P01346 (Rat), P07456 (Bovin), P09535 (Mouse), P10764 (Sheep), P23695 (Pig), P33717 (Chick), P51459 (Horse), Q08279 (Cavpo)

Gene ID

3481 (IGF2), 16002 (Igf2), 24483

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Mouse, Rat, Goat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of Insulin-like growth factor II / IGF2 antibody

Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share approx imately 70% amino acid sequence identity. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular mass of approximately 7.4 kDa. Mouse and human IGF-II share 91% sequence identity.
Insulin-like growth factor II has autocrine, paracrine, and endocrine functions. It is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney cells, and MCF-7 human breast carcinoma cells.

General readings

Pedersen S.K., et al. (2002). Biochem. J. 363: 37-44.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Insulin-like growth factor II / IGF2 (Center) antibody

Formalin fixed and paraffin embedded human placenta tissue stained with IGF2 Antibody Cat.-No AP52163PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH

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