Integrin alpha-7 / ITGA7 antibody

Principal name

Integrin alpha-7 / ITGA7 antibody

SwissProt ID

Q13683 (Human), Q61738 (Mouse), Q63258 (Rat)

Gene ID

3679 (ITGA7), 81008 (Itga7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Neutralisation (NEUT), Paraffin Sections (P)

Background of Integrin alpha-7 / ITGA7 antibody

The integrin family of adhesion molecules participate in important cell-cell and cell-extracellular matrix interactions in a diverse range of biological processes. Integrins are heterodimers consisting of an alpha subunit and a beta subunit. Both alpha and beta subunits are transmembrane proteins with large extracellular domains (>100 kDa for alpha subunit and >75 kDa for beta subunit) that interact with extracellular matrix proteins and relatively small cytoplasmic domains (50 amino acids or less, except for the beta-4 subunit) that interact with cytoskeletal proteins. The adhesiveness of integrins is dynamically regulated in response to cytoplasmic signals, termed “inside-out” signaling. It has been reported that, upon ligand binding, integrins regulate many intracellular signaling pathways that involve cytoplasmic alkalization, intracellular Ca2+ fluctuation, inositol lipid metabolism, protein kinase C, MAP kinase and phosphatidyl inositol kinase. Integrin alpha-7 is a specific cellular receptor for the basement membrane protein laminin-1, as well as for the laminin isoforms-2 and -4. The alpha-7 subunit is expressed mainly in skeletal and cardiac muscle and may be involved in differentiation and migration processes during myogenesis. Absence of integrin alpha-7 results in muscular dystrophy is revealed.

General readings

1. Simon L  et al. Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques. Am J Physiol Regul Integr Comp Physiol 306:R837-44 (2014). PubMed: 24671243
2. Heller KN  et al. AAV-mediated overexpression of human a7 integrin leads to histological and functional improvement in dystrophic mice. Mol Ther 21:520-5 (2013). Human . PubMed: 23319059

20 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Integrin alpha-7 / ITGA7 antibody

Western blot analysis of extracts from COS-7 cells, treated with etoposide (25uM, 1hour), using ITGA7 (light chain, Cleaved-Glu959) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Integrin alpha-7 / ITGA7 antibody

Predicted cell location: Cell membrane, Cytoplasm. Positive control: Human colon and esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human colon and esophagus cancer tissue using ITGA7 antibody at dilution 1/35, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Integrin alpha-7 / ITGA7 antibody

Predicted cell location: Cell membrane, Cytoplasm. Positive control: Human thyroid and esophagus cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human thyroid and esophagus cancer tissue using ITGA7 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Integrin alpha-7 / ITGA7 antibody

Flow Cytometric analysis of mouse Integrin alpha-7 expression on NIH/3T3 (Left) and C2C12 (Right). 
Open Histogram indicates the reaction of Isotypic Control to the cells. 
Shaded Histograms indicate the reaction of ITGA7 antibody to the cells. Mouse IgG1 3C12 Azide Free Ms F, ICC/IF
0.1 mg / €380.00
  Acris Antibodies GmbH

Integrin alpha-7 / ITGA7 antibody

Flow Cytometric analysis of Mouse Integrin alpha-7 expression on NIH/3T3 (Left) and C2C12 (Right). Open Histogram indicates the reaction of Isotypic Control to the cells. 
Shaded Histograms indicate the reaction of ITGA7 antibody to the cells. Mouse IgG1 3C12 FITC Ms F
0.1 ml / €260.00
  Acris Antibodies GmbH

Integrin alpha-7 / ITGA7 antibody

Flow Cytometric analysis of mouse Integrin alpha-7 expression on NIH/3T3 (Left) and C2C12 (Right). 
Open Histogram indicates the reaction of Isotypic Control to the cells. 
Shaded Histograms indicate the reaction of ITGA7 antibody to the cells. Mouse IgG1 3C12 PE Ms F
1 ml (50 Tests) / €350.00
  Acris Antibodies GmbH

Integrin alpha-7 / ITGA7 antibody

Integrin alpha-7 / ITGA7 Mouse IgG1 6A11 Azide Free Ms F, NEUT
0.1 mg / €380.00
  Acris Antibodies GmbH

Integrin alpha-7 / ITGA7 antibody

Integrin alpha-7 / ITGA7 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Integrin alpha-7 / ITGA7 antibody

ITGA7 monoclonal antibody (M01), clone 8G2 Western Blot analysis of ITGA7 expression in Jurkat ( Cat # L017V1 ). Mouse IgG2a 8G2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Integrin alpha-7 / ITGA7 antibody

Integrin alpha-7 / ITGA7 Mouse IgG1 1F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Integrin alpha-7 / ITGA7 (cleaved) antibody

Western blot analysis of extracts from COS7 cells, treated with etoposide 25uM 1h, using ITGA7 (light chain,Cleaved-Glu959) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

Integrin alpha-7 / ITGA7 (cleaved) antibody

Western blot analysis of extracts from COS7 cells, treated with etoposide 25uM 1h, using ITGA7 (light chain,Cleaved-Glu959) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

Integrin alpha-7 / ITGA7 (N-term) antibody

Rat Liver; WB Suggested Anti-Itga7 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Rat Liver; Itga7 antibody - N-terminal region (ARP45241_P050) in Rat Liver cells using Western Blot Rabbit Aff - Purified Hu, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Integrin alpha-7 / ITGA7 antibody

Western blot analysis of Integrin alpha 7 LC expression in HeLa LPS-treated (A); Raw264.7 UV-treated (B); PC12 UV-treated (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Integrin alpha-7 / ITGA7 antibody

Western blot analysis of Integrin alpha 7 LC expression in HeLa LPS-treated (A); Raw264.7 UV-treated (B); PC12 UV-treated (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Integrin alpha-7 / ITGA7 antibody

Western blot analysis of Integrin alpha 7 LC expression in HeLa LPS-treated (A); Raw264.7 UV-treated (B); PC12 UV-treated (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Integrin alpha-7 / ITGA7 antibody

Integrin alpha-7 / ITGA7 Rabbit Aff - Purified Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Integrin alpha-7 / ITGA7 antibody

Immunohistochemistry-Paraffin: ITGA7 Antibody [NBP1-86118] - Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Integrin alpha-7 / ITGA7

Integrin alpha-7 / ITGA7 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Integrin alpha-7 / ITGA7

Integrin alpha-7 / ITGA7 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

20 Item(s)

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