Integrin beta-7 antibody

Principal name

Integrin beta-7 antibody

Alternative names for Integrin beta-7 antibody

Integrin beta-P, M290 IEL antigen, ITGB7, LPAM-1, LPAM1, Integrin alpha 4 beta 7

SwissProt ID

P26010 (Human), P26011 (Mouse)

Gene ID

3695 (ITGB7), 16421 (Itgb7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bab (Baboon)

Available hosts

Mouse, Rabbit, Rat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Functional assay (FN), ELISA (detection) (E(detection))

Background of Integrin beta-7 antibody

Integrin beta7 is a 130 kD glycoprotein, also known as integin betap. It is a member of the Ig superfamily. In association with integrin alpha4 or alphaE chain, beta7 forms alpha4/ beta7 or alphaE/ beta7 heterodimer. alpha4/ beta7 (CD49d/ beta7, LPAM-1) is expressed on majority of peripheral lymphocytes, small subsets of thymocytes and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion, some hematopoietic progenitor cells migration. alphaE/ beta7 (CD103/ beta7, alphaIEL/ beta7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/ beta7 complex is thought to play a role in lymphocyte retention via interaction with its lignd E-Cadherin. The Fib504 antibody has been reported to react with mouse and human beta7 integrin and to block beta7 integrin-mediated cell adhesion in in vitro and in vivo studies.

General readings

Cicala, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(49):20877-20882(2009)
Pentikainen, U., et al. J. Mol. Biol. 393(3):644-657(2009)
Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)
Monteiro, P., et al. Biochem. Biophys. Res. Commun. 358(2):442-448(2007)
Le Floc'h, A., et al. J. Exp. Med. 204(3):559-570(2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 Biotin Ms F
0.5 mg / €360.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 Low Endotoxin Ms C, F, FN
0.5 mg / €410.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Immunofluorescent Staining: Either the TK-1 cell line (LPAM-1 expressing) or the 18-81 MuLV-transformed pre-B cell line (LPAM-1 negative) was labeled with Rat anti-Mouse LPAM-1 and then stained with Goat anti-Rat IgG-FITC. The primary cell populations on each scatter plot were then gated and analyzed by flow cytometry. Amount Used: 1 µg/10e6 cells. Rat IgG2a DATK32 Purified Ms C, F, FN
0.5 mg / €320.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 PE Ms F
0.2 mg / €350.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 PE Ms F
0.1 mg / €300.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

C57BL/6 mouse splenocytes stained with purified DATK32, followed by anti-rat IgG FITC Rat IgG2a DATK32 Aff - Purified Ms C, F, IP, P
0.5 mg / €400.00
  Novus Biologicals Inc.

Integrin alpha 4 beta 7 antibody

Flow cytometry / FACS analysis: Integrin alpha 4 beta 7 Antibody (DATK32) [Biotin] [NBP1-28150] - Either the TK-1 cell line (LPAM-1 expressing) or the 18-81 MuLV-transformed pre-B cell line (LPAM-1 negative) was labeled with rat anti-mouse LPAM-1 and then stained with goat anti-rat IgG-FITC. The primary cell populations on each scatter plot were then gated and analyzed by flow cytometry. Rat IgG2a DATK32 Biotin Ms C, F, P
0.25 mg / €620.00
  Novus Biologicals Inc.

Integrin beta-7 antibody

Staining of normal human peripheral blood cells with 0.06 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.06 ug of Anti-Human/Mouse Integrin ?7 Purified (filled histogram) followed by F(ab')2 Anti-Rat IgG PE .  Cells in the lymphocyte gate were used for analysis. Rat FIB504 Purified Hu, Ms F
0.1 mg / €120.00
  OriGene Technologies, Inc.

Integrin beta-7 (C-term) antibody

Western blot analysis of ITGB7 Antibody (C-term) Cat.-No AP52254PU-N in WiDr cell line lysates (35ug/lane). This demonstrates the ITGB7 antibody detected the ITGB7 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Integrin beta-7 antibody

Integrin beta-7 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Integrin beta-7 antibody

Integrin beta-7 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Integrin beta-7 antibody

Western Blot analysis of ITGB7 expression in transfected 293T cell line (H00003695-T01) by ITGB7 MaxPab polyclonal antibody.

Lane 1: ITGB7 transfected lysate(86.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Integrin beta-7 antibody

Immunofluorescence of monoclonal antibody to ITGB7 on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG2a 8D3 Purified Hu E, ICC/IF
0.1 mg / €370.00
  Abnova Taiwan Corp.

Integrin beta-7 antibody

Either the TK-1 cell line ( Lpam-1 expressing ) or the 18-81 MuLV-transformed pre-B cell line ( Lpam-1 negative ) was labeled with Lpam-1 monoclonal antibody, clone DATK32 ( Cat # MAB3252 ) and then stained with goat anti-rat IgG-FITC. The primary cell populations on each scatter plot were then gated and analyzed by flow cytometry. Rat IgG2a DATK32 Ms C, F
0.5 mg / €400.00
  Abnova Taiwan Corp.

Integrin beta-7 antibody

Flow Cytometry: Integrin beta7 Antibody (FIB504) [NB100-78036] - Human peripheral blood lymphocytes stained with purified FIB504, followed by anti-mouse IgG FITC Rat IgG2a FIB504 Aff - Purified Bab, Hu, Mky, Ms F
0.1 mg / €320.00
  Novus Biologicals Inc.

Integrin beta-7 antibody

Immunohistochemistry: Integrin beta 7 Antibody (2G18) [NB110-94147] - LPAM-1 immunohistochemistry staining of paraffin sections of mouse spleen from LPS exposed animals. Rat IgG2 2G18 Purified Ms F, IP, P
0.1 mg / €420.00
  Novus Biologicals Inc.

Integrin beta-7 antibody

Integrin beta-7 Rat IgG2a FIB504 Aff - Purified Hu, Ms F
0.1 mg / €350.00
  Novus Biologicals Inc.

Integrin beta-7 antibody

Integrin beta-7 Rat IgG2a FIB504 Aff - Purified Hu, Ms F
25 µg / €200.00
  Novus Biologicals Inc.

Integrin beta-7 antibody

Immunohistochemistry-Paraffin: Integrin beta 7 Antibody [NBP1-87412] - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Integrin beta-7

Integrin beta-7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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