Integrin beta-7 antibody

Principal name

Integrin beta-7 antibody

Alternative names for Integrin beta-7 antibody

Integrin beta-P, M290 IEL antigen, ITGB7, LPAM-1, LPAM1, Integrin alpha 4 beta 7

SwissProt ID

P26010 (Human), P26011 (Mouse)

Gene ID

3695 (ITGB7), 16421 (Itgb7)

Available reactivities

Hu (Human), Ms (Mouse), Bab (Baboon)

Available hosts

Mouse, Rat, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C), Functional assay (FN), Flow Cytometry (F), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of Integrin beta-7 antibody

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

General readings

Cicala, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(49):20877-20882(2009)
Pentikainen, U., et al. J. Mol. Biol. 393(3):644-657(2009)
Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)
Monteiro, P., et al. Biochem. Biophys. Res. Commun. 358(2):442-448(2007)
Le Floc'h, A., et al. J. Exp. Med. 204(3):559-570(2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 Biotin Ms F
0.5 mg / €360.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 Low Endotoxin Ms C, F, FN
0.5 mg / €410.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Immunofluorescent Staining: Either the TK-1 cell line (LPAM-1 expressing) or the 18-81 MuLV-transformed pre-B cell line (LPAM-1 negative) was labeled with Rat anti-Mouse LPAM-1 and then stained with Goat anti-Rat IgG-FITC. The primary cell populations on each scatter plot were then gated and analyzed by flow cytometry. Amount Used: 1 µg/10e6 cells. Rat IgG2a DATK32 Purified Ms C, F, FN
0.5 mg / €320.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 PE Ms F
0.2 mg / €350.00
  Acris Antibodies GmbH

Integrin alpha 4 beta 7 antibody

Integrin alpha 4 beta 7 Rat IgG2a DATK32 PE Ms F
0.1 mg / €300.00
  Acris Antibodies GmbH

Integrin beta-7 antibody

  Rat Anti-Human/Mouse Integrin beta 7 Purified (100 ug)  
Staining of normal human peripheral blood cells with 0.06 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.06 ug of Anti-Human/Mouse Integrin ?7 Purified (filled histogram) followed by F(ab')2 Anti-Rat IgG PE .  Cells in the lymphocyte gate were used for analysis. Rat FIB504 Purified Hu, Ms F
0.1 mg / €120.00
  OriGene Technologies, Inc.

Integrin beta-7 (C-term) antibody

Western blot analysis of ITGB7 Antibody (C-term) Cat.-No AP52254PU-N in WiDr cell line lysates (35ug/lane). This demonstrates the ITGB7 antibody detected the ITGB7 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ITGB7 - human gene knockout kit via CRISPR

ITGB7 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ITGB7 - human gene knockout kit via CRISPR

ITGB7 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ITGB7 - human gene knockout kit via CRISPR

ITGB7 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ITGB7 - human gene knockout kit via CRISPR

ITGB7 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Itgb7 - mouse gene knockout kit via CRISPR

Itgb7 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Itgb7 - mouse gene knockout kit via CRISPR

Itgb7 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Itgb7 - mouse gene knockout kit via CRISPR

Itgb7 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Itgb7 - mouse gene knockout kit via CRISPR

Itgb7 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Integrin beta-7

  Recombinant protein of human integrin, beta 7 (ITGB7)  
Integrin beta-7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ITGB7 overexpression lysate

ITGB7 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ITGB7 (mGFP-tagged) - Human integrin, beta 7 (ITGB7), 200 uL, >10^7 TU/mL

Lenti ORF particles, ITGB7 (mGFP-tagged) - Human integrin, beta 7 (ITGB7), 200 uL, >10^7 TU/mL  
200 µl / €1,720.00
  OriGene Technologies, Inc.

Lenti ORF particles, ITGB7 (Myc-DDK tagged) - Human integrin, beta 7 (ITGB7) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ITGB7 (Myc-DDK tagged) - Human integrin, beta 7 (ITGB7) , 200 uL, >10^7 TU/mL  
200 µl / €1,550.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Itgb7 (GFP-tagged) - Mouse integrin beta 7 (Itgb7), 200 uL, >10^7 TU/mL

Lenti ORF particles, Itgb7 (GFP-tagged) - Mouse integrin beta 7 (Itgb7), 200 uL, >10^7 TU/mL  
200 µl / €1,520.00
  OriGene Technologies, Inc.

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