Interferon alpha (IFN alpha) antibody

Principal name

Interferon alpha (IFN alpha) antibody

Alternative names for Interferon alpha (IFN alpha) antibody

B Cell Interferon, IFN-alpha, IFNA, Interferon-alpha, Leukocyte Interferon, Type I Interferon

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Chk (Chicken), Rt (Rat)

Available hosts

Mouse, Rat, Sheep, Rabbit, Chicken, Goat

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), ELISA (capture) (E(capture)), Frozen Sections (C), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT)

Background of Interferon alpha (IFN alpha) antibody

The VeriKine Human Interferon Alpha ELISA Kit has been developed to quantify levels of human IFN-alpha in cell or tissue culture media using a sandwich enzyme linked immunoassay (ELISA). The kit is based on an ELISA with anti-detection antibody conjugated to horseradish peroxidase (HRP). Tetramethyl-benzidine (TMB) is the substrate. The assay is based on the international reference standard for human interferon alpha (Hu-IFN-α) provided by the National Institutes of Health.

Interferons (IFNs) are a family of mammalian cytokines produced by a variety of cells in response to viral infection, immunity stimulators and chemical inducers. They exhibit a wide range of biological activities that include antiviral, anti-proliferative and immunomodulatory functions. When IFN interacts with its cognate receptor, a signal is rapidly transmitted within the cell, often producing an antiviral state. The primary signal transduction cascade promoted by type I IFNs is the JAK1-STAT pathway. Activation of this signal transduction pathway leads to increased gene expression including (2’-5’) oligoadenylate synthetases, Mx proteins, and protein kinase R (PKR) that protect the cell from viral infection.

Interferon Alpha (IFN-alpha), a type I interferon, was one of the first FDA approved biotherapeutic treatments. Accurate measurement of IFN-alpha in cell or tissue culture media allows evaluation of basic immune responses as well as assessing the potency of Toll-Like Receptor (TLR) agonist-based therapeutics in vitro.

General readings

1. Staeheli, P. et al. (2001) Cytokines of Birds: Conserved functions – A largely different look. J. Interferon Cytokine Res. 21: 993-1010.
2. Schwarz, H. et al. (2004) Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay. J. Interferon Cytokine Res. 24: 179-184.
3. Sick, C. et al. (1996) A family of genes coding for two serologically distinct chicken interferons. J. Biol. Chem.
271(13): 7635-7639.
4. Schultz, U. et al. (1995) Recombinant chicken interferon: a potent antiviral agent that lacks intrinsic
macrophage activating factor activity. Eur. J. Immunol. 25: 847-851.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 Purified Hu E
0.5 mg / €220.00
  Acris Antibodies GmbH

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 #14 Azide Free Hu NEUT
0.1 mg / €360.00
  Acris Antibodies GmbH

Interferon alpha (IFN alpha) antibody

Sandwich ELISA using Interferon alpha (IFN alpha) Antibody Goat Aff - Purified Hu E, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Interferon alpha (IFN alpha) antibody

Sandwich ELISA using Interferon alpha (IFN alpha) Antibody Goat Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 UMCh3-IFN-a Purified Chk E, WB
0.5 mg / €540.00
  Acris Antibodies GmbH

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Rabbit Azide Free Chk E, FN, IP, WB
0.5 mg / €540.00
  Acris Antibodies GmbH

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 C10F5 Hu E
0.2 mg / €400.00
  Abnova Taiwan Corp.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 AB5 Purified E, E(detection), WB
1 mg / €360.00
  HyTest Ltd.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG2a AE3 Purified E, E(capture), WB
1 mg / €360.00
  HyTest Ltd.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 C10F5 Purified E
1 mg / €360.00
  HyTest Ltd.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 ST29 Purified Hu FN
0.1 mg / €320.00
  Novus Biologicals Inc.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG2a AE3 Purified Hu E, WB
0.2 mg / €250.00
  Novus Biologicals Inc.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 AB5 Purified Hu E, WB
0.2 mg / €250.00
  Novus Biologicals Inc.

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 MMHA-2 Purified Hu C, E, FN, IP, WB
50 µg / €320.00
  PBL Assay Science

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 MMHA-2 Purified Hu C, E, FN, IP, WB
0.5 mg / €440.00
  PBL Assay Science

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG2b MMHA-8 Purified Hu C, E, FN, IP, WB
50 µg / €270.00
  PBL Assay Science

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 MMHA-11 Purified Hu C, E, FN, IP, WB
50 µg / €270.00
  PBL Assay Science

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 MMHA-11 FITC Hu C, E, F, FN
25 µg / €350.00
  PBL Assay Science

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 MMHA-13 Purified Hu C, E, FN, IP, WB
50 µg / €270.00
  PBL Assay Science

Interferon alpha (IFN alpha) antibody

Interferon alpha (IFN alpha) Mouse IgG1 MMHA-17 Purified Hu C, E, FN, IP, WB
50 µg / €270.00
  PBL Assay Science

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