Interleukin-1 alpha / IL-1A antibody

Principal name

Interleukin-1 alpha / IL-1A antibody

Alternative names for Interleukin-1 alpha / IL-1A antibody

IL-1 alpha, IL1F1, IL1A, Hematopoietin-1

SwissProt ID

O46612 (Canfa), O46613 (Felca), P01582 (Mouse), P01583 (Human), P04822 (Rabit), P08831 (Bovin), P16598 (Rat), P18430 (Pig), Q28385 (Horse), Q28579 (Sheep)

Gene ID

16175 (Il1a), 3552 (IL1A), 24493, 35526 (Act42A)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Mky (Monkey), Bov (Bovine)

Available hosts

Goat, Mouse, Rabbit, Chicken, Sheep, Hamster, Human

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Paraffin Sections (P), Immunoprecipitation (IP), Neutralisation (NEUT), Flow Cytometry (F), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Interleukin-1 alpha / IL-1A antibody

Interleukin-1 is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses. Human IL-1 is an 18.0 kDa protein containing 159 amino acid residues. The interleukin-1 species represent an important family of biologically active mono nuclear cell-derived proteins which are involved in inflammatory reactions and in immune responses. Two distinct human IL-1 species, IL-1alpha and IL-1beta, have been identified. They share similarities such as the same molecular weight, similar biological effects and the same receptors on target cells. IL-1 proteins are produced by macrophages, monocytes and various other cell types such as adult T cell leukemias, fibroblasts, epithelial or endothelial cells, neutrophils and astrocytes. Their biological properties include pyrogenicity, bone resorption, presentation of antigen to T cells and stimulation of B and T lymphocyte proliferation. IL-1alpha is an extracellular peptide of 17 kDa, its activity has been demonstrated in various biological fluids including serum, synovial fluid, gingival fluid, amniotic fluid, sputum, cerebrosinal fluid, urine, and bronchoalveolar lavage (BAL) fluid. Elevated serum or blood levels of IL-1alpha have been found in patients with total hip replacement/ arthroplasties, in patients with recently diagnosted IDDM (Insulin-Dependent Diabetes Mellitus), in case of several carcinomas such as head and neck cancer, pancreatic cancer and thyroid cancer, in experimental acute pyelonephritis, in acute viral hepatitis and in septic shock.

General readings

1. Cerretti, D.P., et al. (1992) Molecular cloning of the IL-1b processing enzyme.
Science 256: 97-100.
2. Thornberry, N.A., et al. (1992) A novel heterodimeric cysteine protease is required for interleukin-1b processing in monocytes.
Nature 356 (6372) 768-74.
3. Lonnemann, G., et al. (1995) Cytokines in human renal interstitial fibrosis. II. Intrinsic Interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts.
Kidney Int 47: 845-854.
4. Lonnemann, G., et al. (1995) Cytokines in juman renal interstitial fibrosis. I Interleukin-a is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts.
Kidney Int 47: 837-844.
5. March, C.J., et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.
Nature 315: 641-645.
6. Mosley, B., et al (1987) The interleukin-1 receptor binds the human interleukin 1a precursor, but not the interleukin 1-b precusor.
J. Biol Chem 262: 2941-2944.
7. Stevenson, F.T., et al. (1993) The 31-kDa precursor of interleukin-1a is myristoylated on specific lysines within the 16-kDa N-terminal propiece.
Proc Natl Acad Sci USA 90: 7245-7249.
8. Stevenson, F.T., et al. (1997) The N-terminal propiece of interleukin 1a is a transforming nuclear oncoprotein.
Proc Natl Acad Sci USA 94: 508-513.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-1 alpha / IL-1A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-IL1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506849) Mouse IgG1 OTI2F8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-IL1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506850) Mouse IgG1 OTI2F11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-IL1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506853) Mouse IgG1 OTI3C3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Interleukin-1 alpha / IL-1A Mouse 364/3B3-14 Purified Hu E, F
50 µg / €120.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

Mouse splenocytes (500,000 cells per well) were activated with LPS (1 ug/ml) for 48 hrs in mouse IL-1 alpha ELISPOT assay.  Control well is medium alone. Hamster ALF-161 Purified Ms E
50 µg / €120.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

Western blot analysis of extracts of  various cell lines, using IL1A antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

This antibody stained formalin-fixed, paraffin-embedded sections of normal human skin.  The recommended concentration is 1.0 ug/ml overnight at 4C.  An HRP-labeled polymer detection system was used with a non-alcohol soluble AEC chromogen.  Enzyme induced antigen retrieval was performed with proteinase K.  Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

To detect mIL-1alpha; by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-1alpha;. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

To detect mIL-1alpha; by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-1alpha; (TA328476) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-1alpha;. Rabbit IgG Purified E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

To detect Rat IL-1alpha; by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Rat IL-1alpha;. Goat IgG Purified Rt E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

To detect Rat IL-1alpha; by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat IL-1alpha; (TA328562) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat IL-1alpha;. Goat IgG Purified Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

Anti-IL1A mouse monoclonal antibody (TA506846) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL1A(RC202084). Mouse IgG1 OTI1G2 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Anti-IL1A mouse monoclonal antibody (TA506847) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL1A(RC202084). Mouse IgG1 OTI2D3 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-IL1A mouse monoclonal antibody (TA506848) at 1:150 dilution. Mouse IgG1 OTI2E7 Purified Hu ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL1A(RC202084) using Anti-IL1A mouse monoclonal antibody (TA506851) at 1:100 dilution. Mouse IgG1 OTI2B4 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

Anti-IL1A mouse monoclonal antibody (TA506852) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL1A(RC202084). Mouse IgG1 OTI3A5 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-1 alpha / IL-1A antibody

ELISA: IL1 alpha Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-1 alpha / IL-1A antibody

Interleukin-1 alpha / IL-1A Mouse IgG1 AS5 FITC Hu F
100 Tests / €360.00
  Acris Antibodies GmbH

Interleukin-1 alpha / IL-1A antibody

Interleukin-1 alpha / IL-1A Mouse IgG1 AS5 Purified Hu C, E, FN, IP
0.5 mg / €400.00
  Acris Antibodies GmbH

Interleukin-1 alpha / IL-1A antibody

Interleukin-1 alpha / IL-1A Mouse IgG1 AS6 Biotin Hu E
0.2 mg / €400.00
  Acris Antibodies GmbH

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