Interleukin-12 alpha / IL12A antibody

Principal name

Interleukin-12 alpha / IL12A antibody

Alternative names for Interleukin-12 alpha / IL12A antibody

IL-12A, IL-12 subunit p35, NKSF1, CLMF p35, Cytotoxic lymphocyte maturation factor 35 kDa subunit, NK cell stimulatory factor chain 1

SwissProt ID

O02743 (Felca), P29459 (Human), P43431 (Mouse), P54349 (Bovin), Q28267 (Canfa), Q29053 (Pig), Q9R103 (Rat), Q9TU27 (Sheep), Q9XSQ6 (Horse)

Gene ID

16159 (Il12a), 3592 (IL12A), 84405

Available reactivities

Ms (Mouse), Hu (Human), Mky (Monkey), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Fe (Feline), Ft (Ferret), GP (Guinea Pig), Gt (Goat), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Sh (Sheep), Bear

Available hosts

Rat, Goat, Mouse, Sheep, Rabbit

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Neutralisation (NEUT)

Background of Interleukin-12 alpha / IL12A antibody

Human Leptin (gene name OB) is a 16 kDa, 146 amino acid (aa) residue, non-glycosylated polypeptide that regulates adipose tissue mass and energy balance . Mature human Leptin shares 87% and 84% aa identity with mouse and rat Leptin, respectively. Human Leptin is active in both the mouse and rat systems . Leptin is expressed almost exclusively by adipocytes and its production is influenced by hormones, cytokines and nutrients and circulates in the plasma, crosses the blood-brain barrier, and is present in human breast milk . The human Leptin receptor (designated ObR or LEPR) is a 150 kDa, 1144 aa residue, type I transmembrane glycoprotein of the IL-6 receptor family of Class I cytokine receptors . The gene for ObR undergoes considerable splicing, forming variants a-d with cytoplasmic domains of variable length, plus the potentially soluble form ObRe . The long form, ObRb (formerly OB RL), is expressed mainly in the hypothalamic arcuate nucleus and is essential for signal transduction . In a concentration-dependent manner, Leptin signaling can have diverse effects, causing neurons that express pro-opiomelanocortin (POMC) peptides to reduce food intake, and neurons that express neuropeptide Y and agouti-related protein (NpY and AgRP) to increase food intake . Leptin is fundamentally a Â?starvation signalÂ? that, when low, prompts increased appetite and decreased energy expenditure . Leptin deficiency influences the immune system, depressing Th1 responses and causing increased frequency of infections . Leptin also regulates puberty, blocking the onset of puberty, or of menses if Leptin deficiency exists due to excessive thinness, such as results from starvation, extreme exercise-induced weight loss, anorexia or cancer-induced cachexia .

General readings

Zhang, Y. et al. (1994) Nature 372:425.

Cohen, S.L. et al. (1996) Nature 382:589.

Friedman, J.M. (2009) Am. J. Clin. Nutr. 89:973S.

Farooqi, I.S. and S. O’Rahilly (2009) Am. J. Clin. Nutr. 89:980S.

Lee, M-J. and S.K. Fried (2009) Am. J. Physiol. Endocrinol. Metab. 296:E1230.

Oswal, A. and G. Yeo (2010) Obesity 18:221.

Ogawa, Y. et al. (1995) J. Clin. Invest. 96:1647.

Verploegen, S.A.B.W. et al. (1997) FEBS Lett. 405:237.

Satoh, N. et al. (1997) Neurosci. Lett. 224:149.

Leroy, P. et al. (1996) J. Biol. Chem. 271:2365.

Savino, F. et al. (2010) Eur. J. Clin. Nutr. Jun 30 [Epub ahead of print].

Cohen, B. et al. (1996) Science 274:1185.

Tartaglia, L.A. et al. (1995) Cell 83:1263.

Murakami, T. et al. (1997) Biochem. Biophys. Res. Commun. 231:26.

Bacart, J. et al. (2010) FEBS Lett. 584:2213.

Tu, H. et al. (2007) J. Cell. Physiol. 212:215.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-12 (p35+p70) antibody

Interleukin-12 (p35+p70) Mouse IgG1 B-T21 Azide Free Hu F, FN
0.5 mg / €460.00
  Acris Antibodies GmbH

Interleukin-12 (p35+p70) antibody

Interleukin-12 (p35+p70) Mouse IgG1 B-T21 FITC Hu F
0.1 mg / €270.00
  Acris Antibodies GmbH

Interleukin-12 (p70+p40) antibody

Interleukin-12 (p70+p40) Mouse IgG1 B-P40 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

Interleukin-12 (p70+p40) antibody

Interleukin-12 (p70+p40) Mouse IgG1 B-P24 Biotin Hu E(detection), Elispot
0.1 mg / €460.00
  Acris Antibodies GmbH

Interleukin-12 alpha / IL12A antibody

  Rabbit Polyclonal IL12A Antibody  
Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-IL12A rabbit polyclonal antibody. (TA590054) Rabbit IgG Purified Hu E, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Biotinylated Anti-Human IL-12 Goat Polyclonal Antibody  
To detect hIL-12 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-12. Goat IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Anti-Human IL-12 Goat Polyclonal Antibody  
To detect hIL-12 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-12 (TA328228) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-12. Goat IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Biotinylated Anti-Murine IL-12 Goat Polyclonal Antibody  
To detect mIL-12 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-12. Goat IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Anti-Murine IL-12 Goat Polyclonal Antibody  
To detect mIL-12 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-12 (TA328496) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-12. Goat IgG Purified E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Rabbit Polyclonal Anti-Interleukin 12A Antibody  
Western blot analysis of Interleukin 12A expression in HeLa cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Rabbit Polyclonal Anti-IL-12A Antibody  
Western blot analysis of IL-12A in HeLa cell lysate with IL-12A antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Rabbit Polyclonal Anti-IL12A Antibody  
Interleukin-12 alpha / IL12A Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  Mouse Monoclonal Anti-IL-12p70 Antibody  
Interleukin-12 alpha / IL12A Mouse IgG1 QS-12p70 Purified Hu E, Elispot
0.5 mg / €413.00
  OriGene Technologies, Inc.

Interleukin-12 alpha / IL12A antibody

  IL12A mouse monoclonal antibody, clone OTI2A8 (formerly 2A8)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-IL12A mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA808081)(1:150) Mouse IgG1 OTI2A8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Interleukin-12 alpha / IL12A antibody

Immunohistochemistry using Interleukin-12 alpha / IL12A Antibody Cat.-No AM01362PU-N Mouse IgG1 Azide Free Hu E, ICC/IF, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

Interleukin-12 alpha / IL12A antibody

Interleukin-12 alpha / IL12A Rat IgG2a C17.8 Azide Free Ms E, E(detection), F, ICC/IF, IP, NEUT, WB
0.1 mg / €200.00
  Acris Antibodies GmbH

Interleukin-12 alpha / IL12A (C-term) antibody

Western blot analysis of IL12A Antibody (C-term) (AP18069PU-N) in MDA-MB231 cell line lysates (35ug/lane). IL12A (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Interleukin-12 alpha / IL12A antibody

Immunohistochemistry (IHC) analyzes of IL-12A antibody (Cat.-No.: AP20613PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Interleukin-12 alpha / IL12A antibody

Human Intestine, Paneth Cells: Formalin-Fixed, Paraffin-Embedded (FFPE). Goat Aff - Purified Bear, Bov, Can, Elephant, Eq, Fe, Ft, GP, Gt, Hu, Mky, Op, Por, Prim, Rb, Sh E, P
50 µg / €470.00
  Acris Antibodies GmbH

Interleukin-12 alpha / IL12A (alpha + beta) antibody

Interleukin-12 alpha / IL12A Rat IgG1 Azide Free Ms E, FN, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

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