Interleukin-13 / IL13 antibody
Principal name
Interleukin-13 / IL13 antibody
Alternative names for Interleukin-13 / IL13 antibody
IL-13, NC30
SwissProt ID
P20109 (Mouse), P35225 (Human), P42203 (Rat), Q95J68 (Pig), Q9N0W9 (Canfa), Q9XSV9 (Bovin)
Ncbi ID
NP_002179.2, NP_032381.1, NP_446280.1, 10090, NP_998968.1, NP_446280, NP_002179, P35225, NM_002188, NP_032381, NM_008355, NM_053828
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))
Background of Interleukin-13 / IL13 antibody
Interleukin-13 (IL-13) is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis . It is secreted by Th1, Th2, Th17, NK, and mast cells, visceral smooth muscle cells, eosinophils, and basophils . This pattern is similar to the expression of Interleukin-4 (IL-4) but also includes subsets of Th1 and Th17 cells that do not secrete IL-4 . IL-13 circulates as a monomer and has two internal disulfide bonds that contribute to its bundled four .-helix configuration . Mature human IL-13 shares approximately 58% amino acid sequence identity with mouse and rat IL-13. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat . IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. On B cells, it promotes cellular activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc. RII. Polymorphisms and upregulation of IL-13 are associated with atopy, asthma, airway hyperresponsiveness, and tissue fibrosis .
The biological effects of IL-13 and IL-4 are closely related due in part to a shared receptor system. IL-13 binds with low affinity to the transmembrane IL-13 R.1 which then forms a signaling complex with the transmembrane IL-4 R. . This high affinity receptor complex also functions as the type 2 IL-4 receptor . Soluble forms of IL-4 R. are expressed which retain ligand binding properties and inhibit IL-4 bioactivity . IL-4 R. also associates with the common gamma chain (.c) to form the type 1 IL-4 receptor complex .
Additionally, IL-13 binds with high affinity to IL-13 R.2 which is expressed as cell surface and soluble forms . IL-13 R.2 functions as a decoy receptor by preventing IL-13 from signaling through the IL-13 R.1/IL-4 R. complex . It also inhibits responsiveness to IL-4 by blocking signaling through IL-4-occupied IL-13 R.1/IL-4 R. receptor complexes . IL-13 R.2 is upregulated during Th2-biased immune responses and limits inflammatory tissue damage . Aside from its decoy function, IL-13 R.2 can signal in response to IL-13 to directly promote tumor cell invasiveness and the development of tissue fibrosis .
General readings
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Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA319041 | Interleukin-13 / IL13 antibody |
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Rabbit polyclonal anti-IL-13 antibody | |||||||
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Rabbit | Purified | Ms | WB |
0.1 mg /
€355.00
|
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OriGene Technologies, Inc. | |||||||
TA320358 | Interleukin-13 / IL13 antibody |
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Rat Anti-Mouse IL-13 Purified (50 ug) | |||||||
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Rat | eBio13A | Purified | Ms | E |
50 µg /
€175.00
|
|
OriGene Technologies, Inc. | |||||||
TA328230 | Interleukin-13 / IL13 antibody |
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Biotinylated Anti-Human IL-13 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
50 µg /
€275.00
|
|
OriGene Technologies, Inc. | |||||||
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TA328231 | Interleukin-13 / IL13 antibody |
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Anti-Human IL-13 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
0.1 mg /
€275.00
|
|
OriGene Technologies, Inc. | |||||||
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TA328498 | Interleukin-13 / IL13 antibody |
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Biotinylated Anti-Murine IL-13 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | E, WB |
50 µg /
€275.00
|
||
OriGene Technologies, Inc. | |||||||
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TA328499 | Interleukin-13 / IL13 antibody |
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Anti-Murine IL-13 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | E, WB |
0.1 mg /
€275.00
|
||
OriGene Technologies, Inc. | |||||||
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TA352743 | Interleukin-13 / IL13 antibody |
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Mouse Monoclonal Anti-IL-13 Antibody | |||||||
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Mouse | IgG1 | B-B13 | Purified | Hu | E, Elispot, F |
0.5 mg /
€415.00
|
OriGene Technologies, Inc. | |||||||
TA804004 | Interleukin-13 / IL13 antibody |
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IL13 mouse monoclonal antibody, clone OTI6D3 (formerly 6D3) | |||||||
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Mouse | IgG1 | OTI6D3 | Purified | Hu | WB |
0.1 ml /
€360.00
|
OriGene Technologies, Inc. | |||||||
PP1034B1 | Interleukin-13 / IL13 antibody |
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Rabbit | Biotin | Hu | E, WB |
25 µg /
€250.00
|
||
OriGene Technologies GmbH | |||||||
PP1034B2 | Interleukin-13 / IL13 antibody |
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Rabbit | Biotin | Hu | E, WB |
50 µg /
€340.00
|
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OriGene Technologies GmbH | |||||||
PP1034P1 | Interleukin-13 / IL13 antibody |
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Rabbit | Aff - Purified | Hu | E, FN, WB |
50 µg /
€250.00
|
||
OriGene Technologies GmbH | |||||||
PP1034P2 | Interleukin-13 / IL13 antibody |
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Rabbit | Aff - Purified | Hu | E, FN, WB |
0.1 mg /
€340.00
|
||
OriGene Technologies GmbH | |||||||
PP1134B1 | Interleukin-13 / IL13 antibody |
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Rabbit | Biotin | Ms | E, WB |
25 µg /
€250.00
|
||
OriGene Technologies GmbH | |||||||
PP1134B2 | Interleukin-13 / IL13 antibody |
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Rabbit | Biotin | Ms | E, WB |
50 µg /
€340.00
|
||
OriGene Technologies GmbH | |||||||
AM01278PU-N | Interleukin-13 / IL13 antibody |
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Rat | IgG2a | JES10-35G12 | Purified | Hu | E |
0.5 mg /
€560.00
|
OriGene Technologies GmbH | |||||||
AM05673FC-N | Interleukin-13 / IL13 antibody |
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Mouse | IgG1 | B-P6 | FITC | Hu | F |
100 Tests /
€400.00
|
OriGene Technologies GmbH | |||||||
AM20534AF-N | Interleukin-13 / IL13 antibody |
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Mouse | IgG1 | A130D 12G5 1E4 | Azide Free | Rt | E, F, P |
0.125 mg /
€425.00
|
OriGene Technologies GmbH | |||||||
AM31267AF-N | Interleukin-13 / IL13 antibody |
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Mouse | IgG1 | B-B13 | Azide Free | Hu | F, FN |
0.5 mg /
€620.00
|
OriGene Technologies GmbH | |||||||
AP09163PU-N | Interleukin-13 / IL13 antibody |
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Rabbit | IgG | Aff - Purified | Por | E, WB |
0.1 mg /
€515.00
|
|
OriGene Technologies GmbH | |||||||
AP09163PU-S | Interleukin-13 / IL13 antibody |
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Rabbit | IgG | Aff - Purified | Por | E, WB |
25 µl /
€190.00
|
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OriGene Technologies GmbH |