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Interleukin-13 / IL13 antibody

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Principal name

Interleukin-13 / IL13 antibody

Alternative names for Interleukin-13 / IL13 antibody

IL-13, NC30

SwissProt ID

P20109 (Mouse), P35225 (Human), P42203 (Rat), Q95J68 (Pig), Q9N0W9 (Canfa), Q9XSV9 (Bovin)

Gene ID

3596 (IL13), 16163 (Il13), 116553, 396721

Ncbi ID

NP_002179.2, NP_032381.1, NP_446280.1, 10090, NP_998968.1, NP_446280, NP_002179, P35225, NM_002188, NP_032381, NM_008355, NM_053828

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Rabbit, Mouse, Rat, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))

Background of Interleukin-13 / IL13 antibody

Interleukin-13 (IL-13) is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis . It is secreted by Th1, Th2, Th17, NK, and mast cells, visceral smooth muscle cells, eosinophils, and basophils . This pattern is similar to the expression of Interleukin-4 (IL-4) but also includes subsets of Th1 and Th17 cells that do not secrete IL-4 . IL-13 circulates as a monomer and has two internal disulfide bonds that contribute to its bundled four .-helix configuration . Mature human IL-13 shares approximately 58% amino acid sequence identity with mouse and rat IL-13. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat . IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. On B cells, it promotes cellular activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc. RII. Polymorphisms and upregulation of IL-13 are associated with atopy, asthma, airway hyperresponsiveness, and tissue fibrosis .

The biological effects of IL-13 and IL-4 are closely related due in part to a shared receptor system. IL-13 binds with low affinity to the transmembrane IL-13 R.1 which then forms a signaling complex with the transmembrane IL-4 R. . This high affinity receptor complex also functions as the type 2 IL-4 receptor . Soluble forms of IL-4 R. are expressed which retain ligand binding properties and inhibit IL-4 bioactivity . IL-4 R. also associates with the common gamma chain (.c) to form the type 1 IL-4 receptor complex .

Additionally, IL-13 binds with high affinity to IL-13 R.2 which is expressed as cell surface and soluble forms . IL-13 R.2 functions as a decoy receptor by preventing IL-13 from signaling through the IL-13 R.1/IL-4 R. complex . It also inhibits responsiveness to IL-4 by blocking signaling through IL-4-occupied IL-13 R.1/IL-4 R. receptor complexes . IL-13 R.2 is upregulated during Th2-biased immune responses and limits inflammatory tissue damage . Aside from its decoy function, IL-13 R.2 can signal in response to IL-13 to directly promote tumor cell invasiveness and the development of tissue fibrosis .

General readings

Townley, R.G. et al. (2011) Discov. Med. 12:513.

Wynn, T.A. (2003) Annu. Rev. Immunol. 21:425.

Joshi, B.H. et al. (2006) Vitam. Horm. 74:479.

McKenzie, A.N. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3735.

Gallo, E. et al. (2012) Eur. J. Immunol. 42:2322.

Moy, F.J. et al. (2001) J. Mol. Biol. 310:219.

Eisenmesser, E.Z. et al. (2001) J. Mol. Biol. 310:231.

Ruetten, H. and C. Thiemermann (1997) Shock 8:409.

Lakkis, F.G. et al. (1997) Biochem. Biophys. Res. Commun. 235:529.

Liu, Y. et al. (2012) Front. Immunol. 3:1.

Aman, M.J. et al. (1996) J. Biol. Chem. 271:29265.

Zurawski, S.M. et al. (1995) J. Biol. Chem. 270:13869.

Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073.

Kruse, S. et al. (1999) Int. Immunol. 11:1965.

Jung, T. et al. (1999) Int. Arch. Allergy Immunol. 119:23.

Kondo, M. et al. (1993) Science 262:1874.

Russell, S.M. et al. (1993) Science 262:1880.

Chen, W. et al. (2008) J. Allergy Clin. Immunol. 122:625.

Chen, W. et al. (2009) J. Immunol. 183:7870.

Daines, M.O. et al. (2007) J. Allergy Clin. Immunol. 119:375.

Kasaian, M.T. et al. (2011) J. Immunol. 187:561.

Andrews, A.-L. et al. (2006) J. Allergy Clin. Immunol. 118:858.

Rahaman, S.O. et al. (2002) Cancer Res. 62:1103.

Sivaprasad, U. et al. (2010) J. Immunol. 185:6802.

Chiaramonte, M.G. et al. (2003) J. Exp. Med. 197:687.

Fujisawa, T. et al. (2009) Cancer Res. 69:8678.

Fujisawa, T. et al. (2011) Int. J. Cancer 131:344.

Fichtner-Feigl, S. et al. (2006) Nat. Med. 12:99.

H00003596-M07 - Interleukin-13 / IL13
Immunoperoxidase of monoclonal antibody to IL13 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]
AP09163PU-N - Interleukin-13 / IL13
Western blot using Protein-A Purified Anti-swine IL-13 antibody shows detection of recombinant swine IL-13 at 13.2kDa (arrow) raised in yeast. Multiple bands are expected of the glycosylated protein. Protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Rockland Immunochemicals, Inc. Anti-swine IL-13. After washing, membrane was probed with Dylight(TM) 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody
AM20534AF-N - Interleukin-13 / IL13
Formalin-Fixed, Paraffin-Embedded Rat Spleen stained with Interleukin-13 / IL13 Antibody Cat.-No AM20534AF-N at 10 µg/ml after heat-induced antigen retrieval.
CEK1209 - Human IL-13 ELISA Kit
Representative Standard Curve
CEK1493 - Mouse IL-13 ELISA Kit
Representative Standard Curve
CEK1494 - Mouse IL-13 ELISA Kit
Representative Standard Curve
CEK1612 - Rat IL-13 ELISA Kit
Representative Standard Curve
TA804004 - Interleukin-13 / IL13
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL13 (RC216947, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL13.
TP700054 - Interleukin-13 / IL13
TP723188 - Interleukin-13 / IL13
TP723189 - Interleukin-13 / IL13
TP723190 - Interleukin-13 / IL13
TP723191 - Interleukin-13 / IL13
TP723192 - Interleukin-13 / IL13
TP723715 - Interleukin-13 / IL13
TP723749 - Interleukin-13 / IL13
TA319041 - Interleukin-13 / IL13
Western blot analysis of IL-13 expression using recombinant mouse IL-13.
TA328230 - Interleukin-13 / IL13
To detect hIL-13 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-13.
TA328230 - Interleukin-13 / IL13
To detect hIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human IL-13 (TA328231) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-13.
TA328231 - Interleukin-13 / IL13
To detect hIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-13 (TA328230) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-13.
TA328231 - Interleukin-13 / IL13
To detect hIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-13 (TA328230) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-13.
TA328498 - Interleukin-13 / IL13
To detect mIL-13 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-13.
TA328498 - Interleukin-13 / IL13
To detect mIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Murine IL-13 (TA328499) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-13.
TA328499 - Interleukin-13 / IL13
To detect mIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-13 (TA328498) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-13.
TA328499 - Interleukin-13 / IL13
To detect mIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-13 (TA328498) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-13.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-13 / IL13 antibody
  Rabbit polyclonal anti-IL-13 antibody  
Western blot analysis of IL-13 expression using recombinant mouse IL-13. Rabbit Purified Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-13 / IL13 antibody
  Rat Anti-Mouse IL-13 Purified (50 ug)  
Interleukin-13 / IL13 Rat eBio13A Purified Ms E
50 µg / €120.00
  OriGene Technologies, Inc.

Interleukin-13 / IL13 antibody
  Biotinylated Anti-Human IL-13 Rabbit Polyclonal Antibody  
To detect hIL-13 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-13. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.
+1 additional image

Interleukin-13 / IL13 antibody
  Anti-Human IL-13 Rabbit Polyclonal Antibody  
To detect hIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-13 (TA328230) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-13. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.
+1 additional image

Interleukin-13 / IL13 antibody
  Biotinylated Anti-Murine IL-13 Rabbit Polyclonal Antibody  
To detect mIL-13 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-13. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.
+1 additional image

Interleukin-13 / IL13 antibody
  Anti-Murine IL-13 Rabbit Polyclonal Antibody  
To detect mIL-13 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-13 (TA328498) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-13. Rabbit IgG Purified E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.
+1 additional image

Interleukin-13 / IL13 antibody
  Mouse Monoclonal Anti-IL-13 Antibody  
Interleukin-13 / IL13 Mouse IgG1 B-B13 Purified Hu E, Elispot, F
0.5 mg / €413.00
  OriGene Technologies, Inc.

Interleukin-13 / IL13 antibody
  IL13 mouse monoclonal antibody, clone OTI6D3 (formerly 6D3)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL13 (RC216947, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL13. Mouse IgG1 OTI6D3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.
 

TrueMAB

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Rat IgG2a JES10-35G12 Purified Hu E
0.5 mg / €450.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Rat IgG1 JES10-2E10 Biotin Hu E
0.5 mg / €540.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Mouse IgG1 B-P6 FITC Hu F
100 Tests / €360.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Formalin-Fixed, Paraffin-Embedded Rat Spleen stained with Interleukin-13 / IL13 Antibody Cat.-No AM20534AF-N at 10 µg/ml after heat-induced antigen retrieval. Mouse IgG1 A130D 12G5 1E4 Azide Free Rt E, F, P
0.125 mg / €470.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Mouse IgG1 B-B13 Azide Free Hu F, FN
0.5 mg / €460.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Mouse IgG1 B-B13 FITC Hu F
0.1 mg / €270.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Mouse IgG1 B-B13 Azide Free Hu E(capture), Elispot
1 mg / €790.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Mouse IgG1 B-P6 Biotin Hu E(detection), Elispot
0.1 mg / €460.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Western blot using Protein-A Purified Anti-swine IL-13 antibody shows detection of recombinant swine IL-13 at 13.2kDa (arrow) raised in yeast. Multiple bands are expected of the glycosylated protein. Protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Rockland Immunochemicals, Inc. Anti-swine IL-13. After washing, membrane was probed with Dylight(TM) 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody Rabbit IgG Aff - Purified Por E, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Western blot using Protein-A Purified Anti-swine IL-13 antibody shows detection of recombinant swine IL-13 at 13.2kDa (arrow) raised in yeast. Multiple bands are expected of the glycosylated protein. Protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Rockland Immunochemicals, Inc. Anti-swine IL-13. After washing, membrane was probed with Dylight(TM) 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody Rabbit IgG Aff - Purified Por E, WB
25 µl / €190.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Interleukin-13 / IL13 antibody
Interleukin-13 / IL13 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

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