Interleukin-18 / IL18 antibody

Principal name

Interleukin-18 / IL18 antibody

Alternative names for Interleukin-18 / IL18 antibody

IL-18, IGIF, IL1F4, Iboctadekin, IL1 gamma, IL-1 gamma, Interferon-gamma-inducing factor, Interleukin-1 gamma

SwissProt ID

O19073 (Pig), P70380 (Mouse), P97636 (Rat), Q14116 (Human), Q8QFQ8 (Chick), Q95M33 (Felca), Q9TU73 (Bovin), Q9XSQ7 (Horse), Q9XSR0 (Canfa)

Gene ID

29197 (Il18)

Available reactivities

Ms (Mouse), Rt (Rat)

Available hosts

Mouse

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of Interleukin-18 / IL18 antibody

Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-γ activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-γ also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-γ in T cells, enhancement of Fas ligand expression by Th1 cells.

2 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-18 / IL18 (37-194) antibody

Western blot analysis of mature rat IL-18 expression in culture supernatant of rat, mouse and human IL-18 transfected 293T cells using AM26651AF-N. Mouse IgG2b 21A12 Azide Free Ms, Rt WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Interleukin-18 / IL18 (37-194) antibody

Immunoprecipitation of recombinant mature rat IL-18 with AM26652AF-N (1) or normal mouse IgG (2). After immunoprecipitated with the antibody, immunocomplex was resolved on SDS-PAGE and immunoblotted with anti-rat IL-18 monoclonal antibody. Mouse IgG2b 91D8 Azide Free Rt IP
0.1 mg / €390.00
  Acris Antibodies GmbH

2 Item(s)

per page
  • LinkedIn