Interleukin-2 / IL2 antibody

Principal name

Interleukin-2 / IL2 antibody

Alternative names for Interleukin-2 / IL2 antibody

IL-2, TCGF, T-cell growth factor

SwissProt ID

O77620 (Rabit), P04351 (Mouse), P05016 (Bovin), P17108 (Rat), P19114 (Sheep), P26891 (Pig), P37997 (Horse), P60568 (Human), Q07885 (Felca), Q29416 (Canfa)

Gene ID

3558 (IL2), 116562 (Il2), 16183, 443401, 280822, 396868

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Mky (Monkey), Sh (Sheep), Av (Birds), Chk (Chicken), Mam (Mammalia), Bov (Bovine), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit, Rat, Chicken, Sheep

Available applications

Enzyme Immunoassay (E), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Functional assay (FN), Flow Cytometry (F), Immunoprecipitation (IP), Dot blot (Dot), Neutralisation (NEUT)

Background of Interleukin-2 / IL2 antibody

Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes . Human IL-2 (also known as T-cell growth factor) is produced by T-cells in response to antigenic or mitogenic stimulation. IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation.

Additionally, IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. It plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types.

The sequence of mouse IL-2 cDNA predicts a 169 amino acid (aa) residue precursor glycoprotein containing a 20 aa residue signal peptide that is cleaved to form the mature protein . At the amino acid sequence level, mature mouse IL-2 is approximately 60% identical to human IL-2 . Whereas human IL-2 is active on mouse cells, mouse IL-2 is species-specific and is inactive on human cells . The gene for IL-2 has been mapped to mouse chromosome 3 .

The biological effects of IL-2 are mediated by specific cell surface receptor complexes. The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains .

IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation and cytocidal activity of monocytes; induces the growth of natural killer cells and stimulates cytokine production by these cells as well as the cytolytic activity of these cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes .

General readings

Goldsmith, M.A. and W.C. Greene (1994) in The Cytokine Handbook, 2nd ed., A. Thomson editor, Academic Press, New York, p. 57.

Hatakeyama, M. and T. Taniguchi (1990) in Peptide Growth Factors and Their Receptors I, Sporn, M.B. and A.B. Roberts eds., Springer-Verlag, New York, p. 523.

Yokota, T. et al. (1985) Proc. Natl. Acd. Sci. USA 82:68.

Kashima, N. et al. (1985) Nature 313:401.

Taniguchi, T. et al. (1983) Nature 302:305.

R&D Systems, Unpublished results.

Fuse, A. et al. (1984) Nucl. Acids Res. 12:9323.

Kashima, N. et al. (1985) Nature 313:401.

Seigel, L.J. et al. (1984) Science 223:175.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-2 / IL2 antibody

  IL2 Rabbit Polyclonal Antibody  
Western blot analysis of CTLL-2 cell lysate using IL-2 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rabbit polyclonal anti-IL-2 antibody  
Western blot analysis using recombinant human IL-2. Lane 1: 50 ng, Lane 2:100 ng. Rabbit Purified Ms NEUT, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rabbit polyclonal anti-IL-2 antibody  
Western blot analysis of IL-2 using recombinant rat IL-2. Rabbit Purified Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rabbit polyclonal anti-IL-2 antibody  
anti-Human IL-2 antibody shows detection of a band ~15 kDa in size corresponding to recombinant human IL-2. The identity of the faint higher molecular weight band may represent a homodimer. Molecular weight markers are also shown (left). After transfer, the membrane was blocked overnight with 3% BSA in TBS followed by reaction with primary antibody at a 1:1,000 dilution. Detection occurred using peroxidase conjugated anti-Rabbit IgG (p/n 611-103-122) secondary antibody diluted 1:40,000. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rabbit polyclonal IL-2 antibody Peroxidase Conjugated  
Western Blot of Rabbit anti-IL-2 Antibody Peroxidase Conjugated Lane 1: Human IL-2 Recombinant Protein Load: 50 ng per lane Secondary antibody: Peroxidase Conjugated IL-2 Antibody at 1:1000 for 60 min at RT Block: MB-070 for 30 min at RT Predicted/Observed size: 16 kDa, 16 kDa Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Biotinylated Anti-Human IL-2 Rabbit Polyclonal Antibody  
To detect hIL-2 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-2. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Biotinylated Anti-Human IL-2 Goat Polyclonal Antibody  
To detect hIL-2 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-2. Goat IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Anti-Human IL-2 Goat Polyclonal Antibody  
To detect hIL-2 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-2 (TA328205) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-2. Goat IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Anti-Human IL-2 Rabbit Polyclonal Antibody  
To detect hIL-2 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-2 (TA328204) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-2. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Biotinylated Anti-Murine IL-2 Rabbit Polyclonal Antibody  
To detect mIL-2 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-2. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Anti-Murine IL-2 Rabbit Polyclonal Antibody  
To detect mIL-2 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-2 (TA328480) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-2. Rabbit IgG Purified E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Biotinylated Anti-Rat IL-2 Rabbit Polyclonal Antibody  
To detect Rat IL-2 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Rat IL-2. Rabbit IgG Purified Rt E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Anti-Rat IL-2 Rabbit Polyclonal Antibody  
To detect Rat IL-2 by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat IL-2 (TA328566) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat IL-2. Rabbit IgG Purified Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rabbit Polyclonal Anti-Interleukin 2 Antibody  
Western blot analysis of Interleukin 2 expression in HT-29 cells Rabbit IgG Purified Hu, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Mouse Monoclonal Anti-IL-2 Antibody  
Interleukin-2 / IL2 Mouse IgG1 B-G5 Purified Hu E, Elispot, F, WB
0.5 mg / €413.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rat Monoclonal Anti-IL-2 Antibody  
Interleukin-2 / IL2 Rat IgG2a JES6-1A12 Purified Ms E, IP
0.5 mg / €413.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rat Monoclonal Anti-IL-2 Antibody  
Interleukin-2 / IL2 Rat IgG2a S4B6-1 Purified Ms F, IP, WB
0.5 mg / €413.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

  Rat Monoclonal Anti-IL-2 Antibody  
Interleukin-2 / IL2 Rat IgG2b JES6-5H4 Purified Ms E, F, IP, WB
0.5 mg / €413.00
  OriGene Technologies, Inc.

Interleukin-2 / IL2 antibody

Interleukin-2 / IL2 Mouse IgG1 B025M Azide Free Hu E, FN
1 mg / €810.00
  Acris Antibodies GmbH

Interleukin-2 / IL2 antibody

Interleukin-2 / IL2 Rat IgG I2-C7 Azide Free Ms FN
0.2 mg / €350.00
  Acris Antibodies GmbH

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