Interleukin-22 / IL22 antibody

Principal name

Interleukin-22 / IL22 antibody

Alternative names for Interleukin-22 / IL22 antibody

IL-22, ILTIF, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor

SwissProt ID

Q9GZX6 (Human), Q9JJY9 (Mouse)

Gene ID

50616 (IL22), 50929 (Il22)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), ELISA (detection) (E(detection))

Background of Interleukin-22 / IL22 antibody

IL-22 is a new cytokine originally identified as a gene induced by IL-9 in murine T lymphocytes, and showing 22% amino acid identity with IL-10. In the mouse, the IL-22 gene is located on chromosome 10, in the same region as the IFN gamma gene. IL-22 is produced by activated Th1 and NK cells acting primarily on epithelial cells and is involved in inflammatory responses. Neither resting nor activated immune cells express IL-22 receptor, and IL-22 does not have any effects on these cells in vitro and in vivo. In contrast, cells of the skin and the digestive and respiratory systems represent putative targets of this cytokine. Thus IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues. IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage. IL-22 regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2 (IL-10R2), IL-22 promotes activation of signal transducer and activator of transcription (STAT) pathway and several other cellular responses. Psoriatic patients show strongly elevated IL-22 plasma levels, which correlated with the disease severity. IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. IL-22 is present in high quantities in the blood of Crohn's disease patients in contrast to IFN-gamma and IL-17.

General readings

Dumoutier L et al. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci U S A 97:10144-9 (2000). PubMed PMID: 10954742

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-22 / IL22 antibody

Western blot analysis of IL-22 in HeLa cell lysate with IL-22 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-22 / IL22 antibody

To detect hIL-22 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-22 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-22. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-22 / IL22 antibody

To detect mIL-22 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIL-22. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-22 / IL22 antibody

To detect mIL-22 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IL-22 (TA328506) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIL-22. Rabbit IgG Purified E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-22 / IL22 antibody

Western Blot: IL22 Antibody (8F11E2) [TA337159] - analysis of IL-22 in A) recombinant protein and B) human spleen lysate using IL-22 antibody at 1 ug/ml. I goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this te Mouse 8F11E2 Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-22 / IL22 antibody

WB Suggested Anti-IL22 Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Aff - Purified Hu E, WB
50 µg / €220.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Biotin Ms E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Aff - Purified Ms E, WB
50 µg / €230.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Aff - Purified Ms E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Interleukin-22 / IL22 antibody

Interleukin-22 / IL22 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Interleukin-22 / IL22 antibody

Human HeLa; WB Suggested Anti-IL22 Antibody Titration: 0.2-1 ug/ml. Positive Control: Hela cell lysate; IL22 antibody - C-terminal region (ARP49523_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Interleukin-22 / IL22 antibody

Immunohistochemistry-Paraffin: IL22 Antibody [NB100-733] - Immunohistochemistry with rabbit antibody to N-terminus of human IL-22 on paraffin section of human tonsil. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €360.00
  Novus Biologicals Inc.

Interleukin-22 / IL22 antibody

Immunohistochemistry: IL22 Antibody [NB100-737] - Immunohistochemistry with rabbit antibody to N-terminus of mouse IL-22 on mouse spleen. Rabbit Aff - Purified Ms E, F, IP, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Interleukin-22 / IL22 antibody

Immunohistochemistry: IL22 Antibody [NB100-738] - Immunohistochemistry with goat anti-IL-22 antibody on paraffin section of human tonsil. Goat Aff - Purified Hu, Ms E, ICC/IF
50 µg / €320.00
  Novus Biologicals Inc.

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