Interleukin-23 alpha / IL23A antibody

Principal name

Interleukin-23 alpha / IL23A antibody

Alternative names for Interleukin-23 alpha / IL23A antibody

IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19

SwissProt ID

Q64FU1 (Horse), Q6LA37 (Cavpo), Q91Z84 (Rat), Q9EQ14 (Mouse), Q9N2H9 (Pig), Q9NPF7 (Human)

Gene ID

51561 (IL23A), 83430 (Il23a)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Functional assay (FN), ELISA (capture) (E(capture)), Enzyme Immunoassay (E)

Background of Interleukin-23 alpha / IL23A antibody

Interleukin 23 (IL-23) is a heterodimeric cytokine that is related to IL-12 . It is composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 . The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The human p19 subunit cDNA encodes a 189 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 170 aa mature protein. Human and mouse p19 subunits share 70% aa sequence identity. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor .1 subunit (IL-12 R.1) and the IL-23-specific receptor subunit (IL-23 R) . IL-23 is produced by dendritic cells and macrophages in response to pathogens including certain bacteria and viruses and/or their components . IL-23 and IL-12 have overlapping but distinct biological activities. The IL-23 immune pathway induces the earliest recruitment of neutrophils to the site of infection while the more classic host defense and cytotoxic response is stimulated by IL-12 . IL-12 drives the development of Th1 cells and induces production of IFN-. by NK cells . In contrast, IL-23 has a role in the development/maintenance of a T cell subset characterized by the production of IL-17A, IL-17F, IL-6, and TNF-. . The induction of IL-17-producing T cells may involve the actions of TGF-. while their survival and expansion may be IL-23-dependent . The IL-23/IL-17 axis is an important mediator of inflammation. In mouse models, transgenic over-expression of IL-23 leads to a systemic inflammatory response . IL-23 effects on IL-17-producing T cells may also enhance the development of several models of autoimmune disease including experimental allergic encephalomyelitis (EAE), collagen-induced arthritis (CIA), colitis, and diabetes (5, 8, 13-17). IL-23 may also play a role in increased tumor growth associated with chronic inflammation . In humans, IL-23 has been found upregulated in several pathologies with dysregulated immune function including psoriasis, CrohnÂ?s disease, and multiple sclerosis .

General readings

Hunter, C.A. (2005) Nat. Rev. Immunol. 5:521.

Langrish, C.L. et al. (2004) Immunol. Rev. 202:96.

McKenzie, B.S. et al. (2006) Trends Immunol. 27:17.

Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

Cua, D.J. et al. (2003) Nature 421:744.

Oppmann, B. et al. (2000) Immunity 13:715.

Parham, C. et al. (2002) J. Immunol. 168:5699.

Langrish, C.L. et al. (2005) J. Exp. Med. 201:233.

Veldhoen, M. et al. (2006) Immunity 24:179.

Mangan, P.R. et al. (2006) Nature 441:231.

Bettelli, E. et al. (2006) Nature 441:235.

Wiekowski, M.T. et al. (2001) J. Immunol. 166:7563.

Nakae, S. et al. (2003) J. Immunol. 171:6173.

Nakae, S. et al. (2003) Proc. Natl. Acad. Sci. USA 100:5986.

Mensah-Brown, E.P. et al. (2006) Eur. J. Immunol. 36:216.

Yen, D. et al. (2006) J. Clin. Invest. 116:1310.

Chen, Y. et al. (2006) J. Clin. Invest. 116:1317.

Langowski, J.L. et al. (2006) Nature 442:461.

Piskin, G. et al. (2006) J. Immunol. 176:1908.

Fuss, I.J. et al. (2006) Inflamm. Bowel Dis. 12:9.

Vaknin-Dembinsky, A. et al. (2006) J. Immunol. 176:7768.

  1. Quick-Filters:
  2. Cited (1)

Items 1 to 20 of 36 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-23 alpha / IL23A antibody

AM20386PU-N IL-23 staining of Formalin-Fixed, Paraffin-Embedded Human Lung, vasculature Mouse IgG1 HLT2736 Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Interleukin-23 alpha / IL23A (C-term) antibody

  Rabbit Polyclonal IL-23 Antibody  
Western blot analysis of IL-23 in Raji lysate with IL-23 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-23 alpha / IL23A (N-term) antibody

  Rabbit Polyclonal IL-23 Antibody  
Western blot analysis of IL-23 in mouse pancreas tissue lysate with IL-23 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-23 alpha / IL23A antibody

  IL-23 p19 Rabbit Polyclonal (N-Terminus) Antibody  
Interleukin-23 alpha / IL23A Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

Interleukin-23 alpha / IL23A antibody

  IL-23 p19 Rabbit Polyclonal (C-Terminus) Antibody  
Interleukin-23 alpha / IL23A Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

Interleukin-23 alpha / IL23A antibody

Labelling on Paraffin Section from psoriasis lesions with IL23 Antibody Clone B-Z23 diluted at 1/500 (background colouration by DAPI). Mouse IgG1 B-Z23 Azide Free Hu FN, P
0.5 mg / €460.00
  Acris Antibodies GmbH

Interleukin-23 alpha / IL23A antibody

Interleukin-23 alpha / IL23A Mouse IgG1 B-B23 Azide Free Ms
0.5 mg / €460.00
  Acris Antibodies GmbH

Interleukin-23 alpha / IL23A antibody

Interleukin-23 alpha / IL23A Mouse IgG1 B-Z23 Azide Free Hu E(capture), Elispot
1 mg / €790.00
  Acris Antibodies GmbH

Interleukin-23 alpha / IL23A antibody

Interleukin-23 alpha / IL23A Mouse IgG1 B-F43 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

Interleukin-23 alpha / IL23A (C-term) antibody

Immunocytochemical staining of Raji cells with Rabbit anti Human interleukin-23 (AP05588PU-N) Rabbit IgG Purified Hu, Ms C, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Interleukin-23 alpha / IL23A (N-term) antibody

Immunohistochemical staining of mouse pancreas With Rabbit anti Human interleukin-23 (AP05589PU-N) Rabbit IgG Purified Hu, Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

IL23A - human gene knockout kit via CRISPR

IL23A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

IL23A - human gene knockout kit via CRISPR

IL23A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL23A - human gene knockout kit via CRISPR

IL23A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL23A - human gene knockout kit via CRISPR

IL23A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il23a - mouse gene knockout kit via CRISPR

Il23a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Il23a - mouse gene knockout kit via CRISPR

Il23a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il23a - mouse gene knockout kit via CRISPR

Il23a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il23a - mouse gene knockout kit via CRISPR

Il23a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Interleukin-23 alpha / IL23A

  Recombinant protein of human interleukin 23, alpha subunit p19 (IL23A)  
Interleukin-23 alpha / IL23A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Items 1 to 20 of 36 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn