Interleukin-23 alpha / IL23A antibody

Principal name

Interleukin-23 alpha / IL23A antibody

Alternative names for Interleukin-23 alpha / IL23A antibody

IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19

SwissProt ID

Q64FU1 (Horse), Q6LA37 (Cavpo), Q91Z84 (Rat), Q9EQ14 (Mouse), Q9N2H9 (Pig), Q9NPF7 (Human)

Gene ID

51561 (IL23A), 83430 (Il23a)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Functional assay (FN), ELISA (capture) (E(capture)), Enzyme Immunoassay (E)

Background of Interleukin-23 alpha / IL23A antibody

Interleukin 23 (IL-23) is a heterodimeric cytokine that is related to IL-12 . It is composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 . The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The human p19 subunit cDNA encodes a 189 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 170 aa mature protein. Human and mouse p19 subunits share 70% aa sequence identity. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor .1 subunit (IL-12 R.1) and the IL-23-specific receptor subunit (IL-23 R) . IL-23 is produced by dendritic cells and macrophages in response to pathogens including certain bacteria and viruses and/or their components . IL-23 and IL-12 have overlapping but distinct biological activities. The IL-23 immune pathway induces the earliest recruitment of neutrophils to the site of infection while the more classic host defense and cytotoxic response is stimulated by IL-12 . IL-12 drives the development of Th1 cells and induces production of IFN-. by NK cells . In contrast, IL-23 has a role in the development/maintenance of a T cell subset characterized by the production of IL-17A, IL-17F, IL-6, and TNF-. . The induction of IL-17-producing T cells may involve the actions of TGF-. while their survival and expansion may be IL-23-dependent . The IL-23/IL-17 axis is an important mediator of inflammation. In mouse models, transgenic over-expression of IL-23 leads to a systemic inflammatory response . IL-23 effects on IL-17-producing T cells may also enhance the development of several models of autoimmune disease including experimental allergic encephalomyelitis (EAE), collagen-induced arthritis (CIA), colitis, and diabetes (5, 8, 13-17). IL-23 may also play a role in increased tumor growth associated with chronic inflammation . In humans, IL-23 has been found upregulated in several pathologies with dysregulated immune function including psoriasis, CrohnÂ?s disease, and multiple sclerosis .

General readings

Hunter, C.A. (2005) Nat. Rev. Immunol. 5:521.

Langrish, C.L. et al. (2004) Immunol. Rev. 202:96.

McKenzie, B.S. et al. (2006) Trends Immunol. 27:17.

Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.

Cua, D.J. et al. (2003) Nature 421:744.

Oppmann, B. et al. (2000) Immunity 13:715.

Parham, C. et al. (2002) J. Immunol. 168:5699.

Langrish, C.L. et al. (2005) J. Exp. Med. 201:233.

Veldhoen, M. et al. (2006) Immunity 24:179.

Mangan, P.R. et al. (2006) Nature 441:231.

Bettelli, E. et al. (2006) Nature 441:235.

Wiekowski, M.T. et al. (2001) J. Immunol. 166:7563.

Nakae, S. et al. (2003) J. Immunol. 171:6173.

Nakae, S. et al. (2003) Proc. Natl. Acad. Sci. USA 100:5986.

Mensah-Brown, E.P. et al. (2006) Eur. J. Immunol. 36:216.

Yen, D. et al. (2006) J. Clin. Invest. 116:1310.

Chen, Y. et al. (2006) J. Clin. Invest. 116:1317.

Langowski, J.L. et al. (2006) Nature 442:461.

Piskin, G. et al. (2006) J. Immunol. 176:1908.

Fuss, I.J. et al. (2006) Inflamm. Bowel Dis. 12:9.

Vaknin-Dembinsky, A. et al. (2006) J. Immunol. 176:7768.

2 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-23 alpha / IL23A (C-term) antibody

  Rabbit Polyclonal IL-23 Antibody  
Western blot analysis of IL-23 in Raji lysate with IL-23 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

Interleukin-23 alpha / IL23A (N-term) antibody

  Rabbit Polyclonal IL-23 Antibody  
Western blot analysis of IL-23 in mouse pancreas tissue lysate with IL-23 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

2 Item(s)

per page
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