Interleukin-31 / IL31 antibody

Principal name

Interleukin-31 / IL31 antibody

Alternative names for Interleukin-31 / IL31 antibody

IL-31

SwissProt ID

Q6EAL8 (Mouse), Q6EBC2 (Human)

Gene ID

386653 (IL31), 76399 (Il31)

Available reactivities

Hu (Human), Ms (Mouse), Eq (Equine), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of Interleukin-31 / IL31 antibody

IL-31 is a 24kD and 164 AA alpha-helical protein with a four-helix bundle structure, preferentially produced by CD 4+ type 2 helper T cells. IL-31 is closely related to the IL-6 type cytokines such as oncostatin M, Leukemia inhibitory factor and cardiotrophin 1. IL-31 signals via binding to a heterodimeric complex that is composed of IL-31 receptor A (IL-31RA) that is highly homologous with the gp 30-like receptor and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes, in epithelial cells, and keratinocytes respectively. On target cells IL-31 binding can induce activation of the JAK/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles including regulation of hematopoiesis and immune response. When overexpressed in transgenic mice, IL-31 induces severe pruritus resembling eczema in humans. Serum IL-31 was previously found overexpressed in adults with atopic dermatitis (AD). Serum measurement of IL-31 in paediatric atopic dermatitis revealed that elevated levels correlate with severity scoring. Activated effector T cells are recruited to the skin by chemokines and cell adhesion molecules. These components in the local microenvironment prolong T cell survival and contribute to the chronicity of these diseases. IL-31 is associated with the promotion of allergic and chronic inflammatory conditions such as dermatitis, pruritus, airway hypersensititvity and inflammatory bowel disease.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Interleukin-31 / IL31 (N-term) antibody

Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 ug/ml. Rabbit IgG Aff - Purified Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-31 / IL31 antibody

Western blot analysis of IL-31 in human skeletal muscle tissue lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 µg/ml. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-31 / IL31 antibody

To detect hIL-31 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIL-31. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Interleukin-31 / IL31 antibody

To detect hIL-31 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IL-31 (TA328248) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-31. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Mouse IgG1 B-S31 Azide Free Hu
0.5 mg / €460.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Mouse IgG2b B-A51 Azide Free Hu
0.5 mg / €460.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Rabbit Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Thymus. Rabbit Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 Control Peptide

Interleukin-31 / IL31
50 µg / €160.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 Control Peptide

Interleukin-31 / IL31
50 µg / €160.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 (N-term) antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with IL31 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Mouse IgG2a 5G9 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Interleukin-31 / IL31 antibody

Immunohistochemistry of Il31 in rat skeletal muscle tissue with Il31 polyclonal antibody ( Cat # PAB13183 ) at 10 µg/ml. Rabbit Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Interleukin-31 / IL31 antibody

Western blot analysis of IL31 in human skeletal muscle tissue lysate with IL31 polyclonal antibody ( Cat # PAB13184 ) at ( A ) 2.5, ( B ) 5 and ( C ) 10 µg/ml. Rabbit Hu, Ms WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Rabbit Hu, Ms P, WB
50 µg / €480.00
  Novus Biologicals Inc.

Interleukin-31 / IL31 antibody

Interleukin-31 / IL31 Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Interleukin-31 / IL31 antibody

Immunohistochemistry-Paraffin: IL31 Antibody [NBP1-77256] - Rat skeletal muscle tissue with IL-31 antibody at 10 ug/mL._x000d_ Rabbit Aff - Purified Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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