Interleukin-5 / IL5 antibody
Principal name
Interleukin-5 / IL5 antibody
Alternative names for Interleukin-5 / IL5 antibody
IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF
SwissProt ID
O02699 (Horse), O08987 (Cavpo), O77515 (Felca), P04401 (Mouse), P05113 (Human), P52173 (Bovin), Q08125 (Rat), Q28586 (Sheep), Q95J76 (Canfa), Q9MYM5 (Pig)
Ncbi ID
NP_000870.1, 9606, 10090, 10116, NP_000870, NP_034688.1, NP_034688, NM_000879, NM_010558
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Paraffin Sections (P), Flow Cytometry (F), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)
Background of Interleukin-5 / IL5 antibody
Interleukin-5(IL-5)is a secreted glycoprotein that belongs to the .-helical group of cytokines . Unlike other family members, it is present as a covalently linked antiparallel dimer . The cDNA for human IL-5 encodes a signal peptide and a 115 amino acid (aa) mature protein. Mature human IL-5 shares 70%, 70%, 62%, 71%, 70% and 66%, aa sequence identity with mouse, rat, canine, equine, feline and porcine IL-5, respectively and shows cross-reactivity with mouse IL-5. IL-5 is primarily produced by CD4+ Th2 cells, but also by activated eosinophils, mast cells, EBV-transformed B cells, Reed-Sternberg cells in HodgkinÂ?s disease, and IL-2-stimulated invariant natural killer T cells (iNKT) (1-3, 6-8). IL-5 increases production and mobilization of eosinophils and CD34+ progenitors from the bone marrow and causes maturation of eosinophil precursors outside the bone marrow . The receptor for human IL-5, mainly expressed by eosinophils, but also found on basophils and mast cells, consists of a unique ligand-binding subunit (IL-5 R.) and a shared Signaltransducing subunit, .c . IL-5 R. first binds IL-5 at low affinity, then associates with preformed .c dimers, forming a high-affinity receptor . IL-5 also binds proteoglycans, potentially enhancing its activity . Soluble forms of IL-5 R. antagonize IL-5 and can be found in vivo . In humans, IL-5 primarily affects cells of the eosinophilic lineage, and promotes their differentiation, maturation, activation, migration and survival, while in mice IL-5 also enhances Ig class switching and release from B1 cells (1-3, 9, 10, 15). IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release .
General readings
Rosenberg, H. F. et al. (2007) J. Allergy Clin. Immunol.119:1303.
Elsas, P.X. and M. I. G. Elsas (2007) Curr. Med. Chem.14:1925.
MartinezMoczygemba,M. and D. P. Huston (2003) J. Allergy Clin. Immunol. 112:653.
Minamitake, Y. et al. (1990) J. Biochem. 107:292.
McKenzie, A. N. et al. (1991) Mol. Immunol. 28:155.
Shakoory, B. et al. (2004) J. Interferon Cytokine Res. 24:271.
Lalani, T. et al. (1999) Ann. Allergy Asthma Immunol. 82:317.
Sakuishi, K. et al. (2007) J. Immunol. 179:3452.
Clutterbuck, E. J. et al. (1989) Blood 73:1504.
Cameron, L. et al. (2000) J. Immunol. 164:1538.
Tavernier, J. et al. (1991) Cell 66:1175.
ZaksZilberman, M. et al. (2008) J. Biol. Chem. 283:13398.
Lipscombe, R. et al. (1998) J. Leukocyte Biol. 63:342.
Tavernier, J. et al. (2000) Blood 95:1600.
Kopf, M. et al. (1996) Immunity 4:15.
Denburg, J. A. et al. (1991) Blood 77:1462.
















Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
---|---|---|---|---|---|---|---|
TA328212 | Interleukin-5 / IL5 antibody |
||||||
Biotinylated Anti-Human IL-5 Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu | E, WB |
50 µg /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA328213 | Interleukin-5 / IL5 antibody |
||||||
Anti-Human IL-5 Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu | E, P, WB |
0.1 mg /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA328486 | Interleukin-5 / IL5 antibody |
||||||
Biotinylated Anti-Murine IL-5 Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | E, WB |
50 µg /
€335.00
|
||
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA328487 | Interleukin-5 / IL5 antibody |
||||||
Anti-Murine IL-5 Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | E, WB |
0.1 mg /
€335.00
|
||
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA335656 | Interleukin-5 / IL5 antibody |
||||||
Rabbit Polyclonal Anti-Il5 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | GP, Hu, Ms, Rb, Rt | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. | |||||||
TA336214 | Interleukin-5 / IL5 antibody |
||||||
Rabbit Polyclonal Anti-IL5 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. | |||||||
TA347874 | Interleukin-5 / IL5 antibody |
||||||
Rabbit Polyclonal Anti-Interleukin 5 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
TA352737 | Interleukin-5 / IL5 antibody |
||||||
Mouse Monoclonal Anti-IL-5 Antibody | |||||||
![]() |
Mouse | IgG1 | QS-5 | Purified | Hu, Macaque | E, Elispot, WB |
0.5 mg /
€413.00
|
OriGene Technologies, Inc. | |||||||
TA352738 | Interleukin-5 / IL5 antibody |
||||||
Mouse Monoclonal Anti-IL-5 Antibody | |||||||
![]() |
Mouse | IgG1 | B-Z25 | Purified | Hu | E, WB |
0.5 mg /
€413.00
|
OriGene Technologies, Inc. | |||||||
AM08178BT-N | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rat | IgG2a | JES1-5A10 | Biotin | Hu | E, E(capture), E(detection) |
0.5 mg /
€330.00
|
Acris Antibodies GmbH | |||||||
AM08178PU-N | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rat | IgG2a | JES1-5A10 | Purified | Hu | E, E(capture), E(detection) |
0.5 mg /
€320.00
|
Acris Antibodies GmbH | |||||||
AP20595PU-N | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | P, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
|||||||
AP23789BT-N | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Biotin | Ms | E, WB |
50 µg /
€340.00
|
||
Acris Antibodies GmbH | |||||||
AP23789BT-S | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Biotin | Ms | E, WB |
25 µg /
€230.00
|
||
Acris Antibodies GmbH | |||||||
AP23789PU-N | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Ms | E, WB |
0.1 mg /
€340.00
|
||
Acris Antibodies GmbH | |||||||
AP23789PU-S | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Ms | E, WB |
50 µg /
€230.00
|
||
Acris Antibodies GmbH | |||||||
PP1027B1 | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Biotin | Hu | E, WB |
25 µg /
€230.00
|
||
Acris Antibodies GmbH | |||||||
PP1027B2 | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Biotin | Hu | E, WB |
50 µg /
€340.00
|
||
Acris Antibodies GmbH | |||||||
PP1027P1 | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu | E, FN, P, WB |
50 µg /
€230.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
|||||||
PP1027P2 | Interleukin-5 / IL5 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu | E, FN, P, WB |
0.1 mg /
€340.00
|
||
Acris Antibodies GmbH | |||||||
![]() |