Involucrin / IVL antibody

Principal name

Involucrin / IVL antibody

SwissProt ID

P07476 (Human), P18174 (Canfa), P18175 (Pig), P48997 (Mouse), P48998 (Rat)

Gene ID

3713 (IVL), 60583 (Ivl)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Por (Porcine), Mky (Monkey), Gorilla, Ms (Mouse), Rt (Rat), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Involucrin / IVL antibody

Involucrin is a precursor protein of the keratinocyte cornified envelope, which is formed beneath the inner surface of the cell membrane during terminal differentiation. Involucrin first appears in the cell cytosol but ultimately becomes cross-linked to membrane proteins by transglutaminase. During keratinocyte terminal differentiation glutamine residues of involucrin become covalently cross-linked to other envelope precursors via covalent ε-(γ-glutamyl) lysine bonds. Moreover, its large size allows involucrin to cross-link molecules that are separated by substantial distances in the cornified envelope. These properties allow a single involucrin molecule to form multiple cross-links, in multiple spatial planes, with other envelope precursors. Involucrin is specifically expressed in Chinese hamster ovarian cells (fibroblasts), PtK2 rat kangaroo kidney cells (simple epithelial) and rat epidermal keratinocytes (stratifying squamous epithelial).

General readings

1. Varone A  et al. Endogenous two-photon fluorescence imaging elucidates metabolic changes related to enhanced glycolysis and glutamine consumption in precancerous epithelial tissues. Cancer Res 74:3067-75 (2014).PubMed: 24686167
2. Ichida JK  et al. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol 10:632-9 (2014).PubMed: 24952596
3. DeRouen MC  et al. Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol 10:112 (2010). ICC/IF ; Human .PubMed: 21067603

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Involucrin / IVL (420-578) antibody

Human Tonsil (formalin-fixed, paraffin-embedded) stained with IVL antibody AP22645PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P, WB
0.25 ml / €380.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Formalin-Fixed, Paraffin-Embedded Human skin stained with Involucrin Antibody Clone SY5 using peroxidase conjugate and DAB chromogen. Note cytoplasmic staining in the epidermal region. Mouse IgG1 SY5 Purified Can, Gorilla, Hu, Mky, Por C, E, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Formalin-Fixed, Paraffin-Embedded Human skin stained with Involucrin Antibody Clone SY5 using peroxidase conjugate and DAB chromogen. Note cytoplasmic staining in the epidermal region. Mouse IgG1 SY5 Purified Can, Gorilla, Hu, Mky, Por C, E, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Formalin-Fixed, Paraffin-Embedded Human skin stained with Involucrin Antibody Clone SY5 using peroxidase conjugate and DAB chromogen. Note cytoplasmic staining in the epidermal region. Mouse IgG1 SY5 Purified Can, Gorilla, Hu, Mky, Por C, E, F, ICC/IF, IP, P, WB
20 µg / €180.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Involucrin / IVL Mouse IgG1 SPM259 Purified Can, Gorilla, Hu, Mky, Por C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Involucrin / IVL Mouse IgG1 SPM259 Purified Can, Gorilla, Hu, Mky, Por C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Involucrin / IVL Mouse IgG1 SPM259 Purified Can, Gorilla, Hu, Mky, Por C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

  Rabbit polyclonal Involucrin antibody  
Western blot analysis of extracts from HuvEc cells, using Involucrin antibody (#TA314106).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Involucrin / IVL antibody

  Rabbit Polyclonal Anti-IVL Antibody  
WB Suggested Anti-IVL Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Hu WB
50 µg / €360.00
  OriGene Technologies, Inc.

Involucrin / IVL antibody

  Rabbit Polyclonal Anti-Involucrin Antibody  
Western blot analysis on HuvEc cell lysate using Involucrin Antibody Rabbit IgG Purified Hu WB
0.1 mg / €335.00
  OriGene Technologies, Inc.

Involucrin / IVL antibody

Involucrin / IVL Mouse IgG1 IL-9 Purified Can, Hu, Por C, ICC/IF, IP, P, WB
0.1 mg / €390.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Immunohistochemistry (IHC) analyzes of Involucrin antibody (Cat.-No.: AP06184PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

Involucrin / IVL antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Involucrin Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P, WB
50 µg / €230.00
  Assay Biotech

Involucrin / IVL antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Involucrin Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €330.00
  Assay Biotech

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ivl (GFP-tagged ORF) - Rat involucrin (Ivl), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ivl (GFP-tagged ORF) - Rat involucrin (Ivl), 200 uL, >10^7 TU/mL  
200 µl / €1,247.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ivl (Myc-DDK-tagged ORF) - Rat involucrin (Ivl), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ivl (Myc-DDK-tagged ORF) - Rat involucrin (Ivl), 200 uL, >10^7 TU/mL  
200 µl / €1,116.00
  OriGene Technologies, Inc.

16 Item(s)

per page
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