IP3 receptor 1 / ITPR1 antibody

Principal name

IP3 receptor 1 / ITPR1 antibody

Alternative names for IP3 receptor 1 / ITPR1 antibody

Type 1 InsP3 receptor, InsP3R1, INSP3R1, IP3R1, Inositol 1,4,5-trisphosphate receptor type 1, Type 1 inositol 1,4,5-trisphosphate receptor

SwissProt ID

P11881 (Mouse), P29994 (Rat), Q14643 (Human), Q9TU34 (Bovin)

Gene ID

3708 (ITPR1), 25262 (Itpr1)

Available reactivities

Can (Canine), Ms (Mouse), Rt (Rat), Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of IP3 receptor 1 / ITPR1 antibody

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations.
Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. Type-I IP3R has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II protein is found predominantly in the brain. Isoform III expression has been shown to occur in pancreatic islets, kidney and the gastrointestinal tract.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IP3 receptor 1 / ITPR1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human brain, cerebellum tissue stained with ITPR1 Antibody Cat.-No AP08902PU-N at 10 µg/m.after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IP3 receptor 1 / ITPR1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L24/18 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

IP3 receptor 1 / ITPR1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L24/18 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

IP3 receptor 1 / ITPR1 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using InsP3R1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

IP3 receptor 1 / ITPR1 antibody

Western blot analysis of IP3 Receptor on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S24-18 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IP3 receptor 1 / ITPR1 antibody

Western blot analysis of rat brain membranes: 1. Anti-IP3 Receptor-1 antibody, (1:2000). 2. Anti-IP3 Receptor-1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

IP3 receptor 1 / ITPR1 antibody

IP3 receptor 1 / ITPR1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

IP3 receptor 1 / ITPR1 antibody

IP3 receptor 1 / ITPR1 Mouse IgG2a 2B6 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

IP3 receptor 1 / ITPR1 pSer1598/1588 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

IP3 receptor 1 / ITPR1 pSer1598/1588 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

IP3 receptor 1 / ITPR1 pSer1764 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IP3R1 (Phospho-Ser1764) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

IP3 receptor 1 / ITPR1 pSer1764 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IP3R1 (Phospho-Ser1764) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

IP3 receptor 1 / ITPR1 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using InsP3R1 (Ab-1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

IP3 receptor 1 / ITPR1 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using InsP3R1 (Ab-1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

IP3 receptor 1 / ITPR1 antibody

Western Blot and Immunoprecipitation: IP3R1 Antibody [NBP1-21398]-Whole cell lysate from HeLa cells.  Affinity purified rabbit anti-IP3R1 antibody. IP3R1 was also  immunoprecipitated by rabbit anti-IP3R1 antibody NBP1-21397. Rabbit IgG Aff - Purified Hu IP, WB
20 µg / €440.00
  Novus Biologicals Inc.

IP3 receptor 1 / ITPR1 antibody

IP3 receptor 1 / ITPR1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €360.00
  Novus Biologicals Inc.

IP3 receptor 1 / ITPR1 antibody

IP3 receptor 1 / ITPR1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €290.00
  Novus Biologicals Inc.

IP3 receptor 1 / ITPR1 antibody

Western Blot: ITPR1 Antibody (EPR4537) [NBP1-95155] - Analysis on (A) rat brain, (B) SH-SY5Y, (C) mouse brain, and (D) HeLa lysates using anti-ITPR1. Rabbit EPR4537 Purified Hu, Ms, Rt WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IP3 receptor 1 / ITPR1

IP3 receptor 1 / ITPR1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

IP3 receptor 1 / ITPR1

IP3 receptor 1 / ITPR1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

20 Item(s)

per page
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