IP3 receptor 1 / ITPR1 antibody

Principal name

IP3 receptor 1 / ITPR1 antibody

Alternative names for IP3 receptor 1 / ITPR1 antibody

Type 1 InsP3 receptor, InsP3R1, INSP3R1, IP3R1, Inositol 1,4,5-trisphosphate receptor type 1, Type 1 inositol 1,4,5-trisphosphate receptor

SwissProt ID

P11881 (Mouse), P29994 (Rat), Q14643 (Human), Q9TU34 (Bovin)

Gene ID

3708 (ITPR1), 25262 (Itpr1), 16438

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of IP3 receptor 1 / ITPR1 antibody

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IP3 receptor 1 / ITPR1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human brain, cerebellum tissue stained with ITPR1 Antibody Cat.-No AP08902PU-N at 10 µg/m.after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IP3 receptor 1 / ITPR1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L24/18 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

IP3 receptor 1 / ITPR1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L24/18 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

IP3 receptor 1 / ITPR1 antibody

  Mouse Monoclonal Anti-IP3 Receptor Antibody  
Western blot analysis of IP3 Receptor on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S24-18 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IP3 receptor 1 / ITPR1 antibody

  Rabbit Polyclonal Anti-IP3 Receptor-1  
Western blot analysis of rat brain membranes: 1. Anti-IP3 Receptor-1 antibody, (1:2000). 2. Anti-IP3 Receptor-1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

IP3 receptor 1 / ITPR1 pSer1598/1588 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

IP3 receptor 1 / ITPR1 pSer1598/1588 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

IP3 receptor 1 / ITPR1 pSer1764 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IP3R1 (Phospho-Ser1764) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €230.00
  Assay Biotech

IP3 receptor 1 / ITPR1 pSer1764 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IP3R1 (Phospho-Ser1764) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €330.00
  Assay Biotech

IP3 receptor 1 / ITPR1 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using InsP3R1 (Ab-1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

IP3 receptor 1 / ITPR1 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using InsP3R1 (Ab-1598/1588) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Itpr1 - mouse gene knockout kit via CRISPR

Itpr1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Itpr1 - mouse gene knockout kit via CRISPR

Itpr1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Itpr1 - mouse gene knockout kit via CRISPR

Itpr1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Itpr1 - mouse gene knockout kit via CRISPR

Itpr1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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